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Registry of Toxic Effects of Chemical Substances (RTECS)

Methacrylic acid, 2-(dimethylamino)ethyl ester

RTECS #

OZ4200000

CAS #

2867-47-2

Updated

April 2012

Molecular Weight

157.24

Molecular Formula

C8H15NO2

Synonyms

2-(Dimethylamino)ethyl methacrylate
2-Dimethylaminoethyl methacrylate
2-Dimethylaminoethylester kyseliny methakrylove (Czech)
Ageflex FM-1
beta-Dimethylaminoethyl methacrylate
Ethanol, 2-(dimethylamino)-, methacrylate
N,N-Dimethylaminoethyl methacrylate
USAF RH-3

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1800 mg/m3/2H85GMAT -,55,1982
inhalation/rat lethal concentration (50 percent kill): 620 mg/m3/4H85GMAT -,55,1982
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgNTIS** AD277-689
intravenous/Dog lowest published lethal dose: 20800 nL/kgJPMSAE 63,376,1974
oral/rat lethal dose (50 percent kill): 1751 mg/kg85GMAT -,55,1982

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 7000 mg/kg/14D- intermittentGastrointestinal: Changes in structure or function of salivary glandsTOXID9 66,251,2002
oral/rat lowest published toxic dose: 35 gm/kg/5W- intermittentBehavioral: TremorTOXID9 66,251,2002
oral/rat lowest published toxic dose: 42 gm/kg/6W- intermittentSpinal Cord: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold
TOXID9 66,251,2002

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 80 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1344; Number of Industries 3; Total Number of Facilities 129; Number of Occupations 4; Total Number of Employees Exposed 10637; Total Number of Female Employees Exposed 429
National Occupational Hazard Survey 1974Hazard Code A1344; Number of Industries 15; Total Number of Facilities 438; Number of Occupations 18; Total Number of Employees Exposed 3056

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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