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Methacrylic acid, 2 - (dimethylamino) ethyl ester

RTECS #: OZ4200000

CAS #: 2867-47-2


UPDATE: August 2006 MW: 157.24 MF: C8H15NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - (Dimethylamino) ethyl methacrylate
  2. 2 - Dimethylaminoethylester kyseliny methakrylove (Czech)
  3. 2 - Dimethylaminoethyl methacrylate
  4. Ageflex FM - 1
  1. Ethanol, 2 - (dimethylamino) - , methacrylate
  2. N,N - Dimethylaminoethyl methacrylate
  3. USAF RH - 3
  4. beta - Dimethylaminoethyl methacrylate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 1,800 mg/m3/2 hour N/R 85GMAT -,55,1982
inhalation
rat
lethal concentration (50 percent kill): 620 mg/m3/4 hour N/R 85GMAT -,55,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD277-689
intravenous
dog
lowest published lethal dose: 20,800 nL/kg N/R JPMSAE 63,376,1974
oral
rat
lethal dose (50 percent kill): 1,751 mg/kg N/R 85GMAT -,55,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7,000 mg/kg/14 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands TOXID9 66,251,2002
oral
rat
lowest published toxic dose: 35 gm/kg/5 week- intermittent Behavioral: Tremor TOXID9 66,251,2002
oral
rat
lowest published toxic dose: 42 gm/kg/6 week- intermittent Spinal Cord: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold
TOXID9 66,251,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
EVHPAZ 11,141,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 80 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1344;
Number of Industries 15;
Total Number of Facilities 438;
Number of Occupations 18;
Total Number of Employees Exposed 3,056
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1344;
Number of Industries 3;
Total Number of Facilities 129;
Number of Occupations 4;
Total Number of Employees Exposed 10,637;
Total Number of Female Employees Exposed 429


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as flocculants and coagulants, paper processing, coatings, adhesives, textile treating
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as flocculants and coagulants, paper processing, coatings, adhesives, textile treating

NIOSH PROFILE (METHACRYLIC ACID AND ITS ESTERS), SRC, 12/79

RTECS Compound Description:
   Drug
   Mutagen

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