Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Methacrylic acid, butyl ester

RTECS #

OZ3675000

CAS #

97-88-1

Updated

April 2012

Molecular Weight

142.22

Molecular Formula

C8H14O2

Synonyms

2-Methyl-butylacrylaat (Dutch)
2-Methyl-butylacrylat (German)
2-Methyl-butylacrylate
2-Propenoic acid, 2-methyl-, butyl ester
Butil metacrilato (Italian)
Butyl 2-methacrylate
Butyl 2-methyl-2-propenoate
Butyl methacrylate
Butylester kyseliny methakrylove (Czech)
Butylmethacrylaat (Dutch)
Methacrylate de butyle (French)
Methacrylsaeurebutylester (German)
n-Butyl methacrylate
n-Butylmethacrylate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 µL mildNTIS** OTS0538268

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 600 ppm/6H (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOSCF2 50,136,1999
intraperitoneal/rat 2304 mg/kg (5-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)JDREAF 51,1632,1972
intraperitoneal/rat 690 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
JDREAF 51,1632,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lethal concentration: >17 gm/m3/7.6HJBMRBG 8,11,1974
inhalation/rat lethal concentration (50 percent kill): 4910 ppm/4HOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
JTEHD6 16,811,1985
intraperitoneal/mouse lethal dose (50 percent kill): 1490 mg/kgJPMSAE 62,778,1973
intraperitoneal/rat lethal dose (50 percent kill): 2304 mg/kgJDREAF 51,1632,1972
intravenous/Dog lowest published lethal dose: 166 µL/kgJPMSAE 63,376,1974
oral/mouse lethal dose (50 percent kill): 12900 mg/kgGISAAA 41(4),6,1976
oral/rabbit lethal dose (50 percent kill): 25 gm/kgGISAAA 41(4),6,1976
oral/rat lethal dose (50 percent kill): 16 gm/kgGTPZAB 25(11),57,1981
skin/guinea pig lethal dose (50 percent kill): >20 mL/kgNTIS** 0TS0516721
skin/rabbit lethal dose (50 percent kill): 11300 µL/kgAIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 975 mg/kg/39W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 41(4),6,1976
oral/rat lowest published toxic dose: 107 gm/kg/17W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 19(9),57,1975
oral/rat lowest published toxic dose: 975 mg/kg/39W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Alteration of classical conditioning

Liver: Other changes
GISAAA 41(4),6,1976

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWIJTOFN 24,53,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (145 mg/m3), MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (145 mg/m3), sen, NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (300 mg/m3);short term exposure limit 75 ppm (450 mg/m3), Sen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 59 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84160; Number of Industries 16; Total Number of Facilities 779; Number of Occupations 19; Total Number of Employees Exposed 10001; Total Number of Female Employees Exposed 2931
National Occupational Hazard Survey 1974Hazard Code 84160; Number of Industries 37; Total Number of Facilities 1231; Number of Occupations 39; Total Number of Employees Exposed 31041

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP