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Registry of Toxic Effects of Chemical Substances (RTECS)

Methacrylaldehyde

RTECS #

OZ2625000

CAS #

78-85-3

Updated

February 2006

Molecular Weight

70.10

Molecular Formula

C4H6O

Synonyms

2-Methylacrolein
2-Methylpropenal
2-Propenal, 2-methyl-
Acrolein, 2-methyl-
alpha-Methylacrolein
Isobutenal
Methacrolein
Methacrylic aldehyde
Methakrylaldehyd (Czech)
Methylacrylaldehyde
NSC 8260

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe85JCAE -,271,1986
skin /rabbit 2 mg/24H severe85JCAE -,271,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageliver/rat7100 µmol/LMUREAV 419,69,1998
mutation in microorganisms/Escherichia coli300 nmol/plateMUREAV 516,81,2002
mutation in microorganisms/Salmonella typhimurium1 µmol/L/20M (-enzymatic activation step)EMMUEG 37,324,2001
mutation in microorganisms/Salmonella typhimurium1.8 µmol/L/20M (+enzymatic activation step)EMMUEG 37,324,2001
mutation in microorganisms/Salmonella typhimurium500 nmol/L (+enzymatic activation step)MUREAV 148,25,1985
mutation in microorganisms/Salmonella typhimurium500 µmol/L (-enzymatic activation step)MUREAV 93,305,1982

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lethal concentration (50 percent kill): 810 mg/m3/2HVCVGK* -,389,1984
inhalation/rat Lowest published lethal concentration: 125 ppm/4HJIHTAB 31,343,1949
oral/rat lethal dose (50 percent kill): 140 mg/kgUCDS** 7/21/1965
skin/rabbit lethal dose (50 percent kill): 430 µL/kgJIHTAB 31,60,1949

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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