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Methacrylaldehyde

RTECS #: OZ2625000

CAS #: 78-85-3


UPDATE: February 2006 MW: 70.10 MF: C4H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2 - Methylacrolein
  2. 2 - Methylpropenal
  3. 2 - Propenal, 2 - methyl -
  4. Acrolein, 2 - methyl -
  5. Isobutenal
  6. Methacrolein
  1. Methacrylic aldehyde
  2. Methakrylaldehyd (Czech)
  3. Methylacrylaldehyde
  4. NSC 8260
  5. alpha - Methylacrolein


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 Ág/24 hour severe 85JCAE -,271,1986
skin
rabbit
2 mg/24 hour severe 85JCAE -,271,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage rat liver 7,100 Ámol/L MUREAV 419,69,1998
mutation in microorganisms Escherichia coli 300 nmol/plate MUREAV 516,81,2002
mutation in microorganisms Salmonella typhimurium 500 nmol/L (+enzymatic activation step) MUREAV 148,25,1985
mutation in microorganisms Salmonella typhimurium 500 Ámol/L (-enzymatic activation step) MUREAV 93,305,1982
mutation in microorganisms Salmonella typhimurium 1 Ámol/L/20 minute (-enzymatic activation step) EMMUEG 37,324,2001
mutation in microorganisms Salmonella typhimurium 1.8 Ámol/L/20 minute (+enzymatic activation step) EMMUEG 37,324,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lethal concentration (50 percent kill): 810 mg/m3/2 hour N/R VCVGK* -,389,1984
inhalation
rat
lowest published lethal concentration: 125 ppm/4 hour N/R JIHTAB 31,343,1949
oral
rat
lethal dose (50 percent kill): 140 mg/kg N/R UCDS** 7/21/1965
skin
rabbit
lethal dose (50 percent kill): 430 ÁL/kg N/R JIHTAB 31,60,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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