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Registry of Toxic Effects of Chemical Substances (RTECS)

Mercury, dimethyl

RTECS #

OW3010000

CAS #

593-74-8

Updated

September 201

Molecular Weight

230.67

Molecular Formula

C2H6Hg

Synonyms

Dimethyl mercury
Methyl mercury

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human43400 nmol/LMUREAV 281,255,1992
Cytogenetic Analysisovary/hamster40 mg/LMUREAV 290,281,1993
Cytogenetic Analysisother cell types/human1.8 µmol/L/48HMUREAV 577S,1,2005
DNA Damagelymphocyte/rat20 mg/LEMMUEG 22,172,1993
DNA Damageother cell types/rat20 mg/LEMMUEG 22,172,1993
DNA Damage/Other microorganisms600 mg/LNATUAS 257,422,1975
DNA Damagelymphocyte/human20 mg/LEMMUEG 22,172,1993
other mutation test systemsother cell types/mouse25 mg/LMUREAV 17,93,1973
sex chromosome loss and nondisjunctionlymphocyte/human1730 nmol/LMUREAV 281,255,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 23 mg/kg (7D preg-7D after birth)Reproductive: Effects on newborn: Biochemical and metabolicNRTXDN 27,468,2006
oral/rat 22.8 mg/kg (14D pre-21D after birth)Reproductive: Effects on newborn: BehavioralNETEEC 28,59,2006
oral/rat 24 mg/kg (28D pre-20D pregnant)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
NETEEC 28,251,2006
oral/rat 48 mg/kg (28D pre-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NETEEC 28,251,2006
oral/rat 2.6 mg/kg (6D preg-10D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 -,283,2009
oral/rat 39 mg/kg (6D preg-10D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TOXID9 -,37,2009
unreported route/rat 39 mg/kg (6D preg-10D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
TOXID9 -,37,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/rat lowest published toxic dose: 0.325 mg/kg/45MBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
BJMRDK 40,1361,2007
intracerebral/rat lowest published toxic dose: 2.17 µg/kg/30MBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumBJMRDK 40,1361,2007
intramuscular/mouse lowest published toxic dose: 1.4 mg/kgBrain and Coverings: Other degenerative changes

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
TOXID9 72(Suppl 1),403,2003
intraspinal/rat lowest published toxic dose: 46.1 mg/kgBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumEESADV 55,173,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 48 mg/kg/14D- intermittentBlood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response
TOXID9 72,173,2003
oral/rat lowest published toxic dose: 14 mg/kg/14D- continuousKidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
JAPTO* 29,126,2009
oral/rat lowest published toxic dose: 42 mg/kg/14D- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Changes in leukocyte (WBC) count
JAPTO* 29,126,2009
oral/rat lowest published toxic dose: 28 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 60,415,2001
oral/rat lowest published toxic dose: 291.2 mg/kg/104W- intermittentBehavioral: Change in motor activity (specific assay)

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NETEEC 27,629,2005
oral/rat : 23 mg/kg/23D- continuousBiochemical: Metabolism (intermediary): Other proteinsNRTXDN 27,468,2006
oral/rat : 48 mg/kg/48D- intermittentBehavioral: Change in motor activity (specific assay)NETEEC 28,251,2006
oral/rat lowest published toxic dose: 28 mg/kg/14D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TOLED5 169,109,2007
oral/rat lowest published toxic dose: 10 mg/kg/5D- intermittentBehavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests
TOLED5 169,109,2007
subcutaneous/rat lowest published toxic dose: 60 mg/kg/20D- intermittentBehavioral: Change in psychophysiological testsTOXID9 -,350,2009
unreported route/mouse lowest published toxic dose: 30 µg/kg/6D- intermittentBlood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response
TOXID9 72,376,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.01 mg(Hg)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-short term exposure limit 0.03 mg(Hg)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 58,239,1993
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 58,239,1993
TOXICOLOGY REVIEWCMAJAX 165,205,2001
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWNETOX* 26,483,2005
TOXICOLOGY REVIEWNETOX* 26,511,2005
TOXICOLOGY REVIEWNRTXDN 27,567,2006
TOXICOLOGY REVIEWNETEEC 28,260,2006
TOXICOLOGY REVIEWNETEEC 28,363,2006
TOXICOLOGY REVIEWENTOX* -,54,2005
TOXICOLOGY REVIEWENTOX* -,98,2005
TOXICOLOGY REVIEWCRTXB2 36,609,2006
TOXICOLOGY REVIEWCRTXB2 34,301,2004
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWREPTED 23,414,2007
TOXICOLOGY REVIEWHBTME* ,213,2007
TOXICOLOGY REVIEWHTOPA* 1,701,2002
TOXICOLOGY REVIEWITODC* -,327,2004
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWTOLED5 182,48,2008
TOXICOLOGY REVIEWMUREAV 674,3,2009
TOXICOLOGY REVIEWREPTED 26,81,2008
TOXICOLOGY REVIEWRTOPDW 51,215,2008
TOXICOLOGY REVIEWNRTXDN 30,338,2009
TOXICOLOGY REVIEWTXAPA9 243,191,2010
TOXICOLOGY REVIEWPHMREP 60,212,2009
TOXICOLOGY REVIEWPHMREP 60,212,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.001 ppm (0.01 mg(Hg)/m3)DTLWS* 3,22,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.01 mg(Hg)/m3, short term exposure limit 0.03 mg(Hg)/m3, JUL2008
Occupational Exposure Limit-FINLANDtime-weighted average 0.01 mg(Hg)/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.01 mg(Hg)/m3, Skin, FEB2006
Occupational Exposure Limit-KOREAtime-weighted average 0.01 mg(Hg)/m3, short term exposure limit 0.03 mg(Hg)/m3, skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.01 mg(Hg)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.01 mg(Hg)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.01 mg(Hg)/m3, MAC(short term exposure limit) 0.01 mg(Hg)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.2 mg(Hg)/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(Hg)/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.01 mg/m3, inhal, skin, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.01 mg(Hg)/m3, short term exposure limit 0.04 mg(Hg)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.01 mg(Hg)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.01 mg(Hg)/m3, Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.01 mg(Hg)/m3 (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.01 mg(Hg)/m3 (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.01 mg(Hg)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.01 mg(Hg)/m3 (skin)CFRGBR 29,1915.1000,1993

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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