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Mercury, dimethyl

RTECS #: OW3010000

CAS #: 593-74-8

UPDATE: May 2009 MW: 230.67 MF: C2H6Hg


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Dimethyl mercury
  1. Methyl mercury


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 40 mg/L MUREAV 290,281,1993
cytogenetic analysis human lymphocyte 43,400 nmol/L MUREAV 281,255,1992
cytogenetic analysis human other cell types 1.8 µmol/L/48 hour MUREAV 577S,1,2005
DNA damage human lymphocyte 20 mg/L EMMUEG 22,172,1993
DNA damage other microorganisms 600 mg/L NATUAS 257,422,1975
DNA damage rat lymphocyte 20 mg/L EMMUEG 22,172,1993
DNA damage rat other cell types 20 mg/L EMMUEG 22,172,1993
other mutation test systems mouse other cell types 25 mg/L MUREAV 17,93,1973
sex chromosome loss and nondisjunction human lymphocyte 1,730 nmol/L MUREAV 281,255,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 23 mg/kg (7 day pregnant-7 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic NRTXDN 27,468,2006
oral
rat 		lowest published toxic dose: 22.8 mg/kg (14 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Behavioral NETEEC 28,59,2006
oral
rat 		lowest published toxic dose: 24 mg/kg (28 day prior to copulation-20 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		NETEEC 28,251,2006
oral
rat 		lowest published toxic dose: 48 mg/kg (28 day prior to copulation-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NETEEC 28,251,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 0.325 mg/kg/45 minute Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		BJMRDK 40,1361,2007
intracerebral
rat 		lowest published toxic dose: 2.17 µg/kg/30 minute Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum BJMRDK 40,1361,2007
intramuscular
mouse 		lowest published toxic dose: 1.4 mg/kg Brain and Coverings: Other degenerative changes

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals 		TOXID9 72(Suppl 1),403,2003
intraspinal
rat 		lowest published toxic dose: 46.1 mg/kg Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum EESADV 55,173,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 48 mg/kg/14 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response 		TOXID9 72,173,2003
oral
rat 		lowest published toxic dose: 28 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 60,415,2001
oral
rat 		lowest published toxic dose: 291.2 mg/kg/104 week- intermittent Behavioral: Change in motor activity (specific assay)

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NETEEC 27,629,2005
oral
rat 		: 23 mg/kg/23 day- continuous Biochemical: Metabolism (intermediary): Other proteins NRTXDN 27,468,2006
oral
rat 		: 48 mg/kg/48 day- intermittent Behavioral: Change in motor activity (specific assay) NETEEC 28,251,2006
oral
rat 		lowest published toxic dose: 28 mg/kg/14 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		TOLED5 169,109,2007
oral
rat 		lowest published toxic dose: 10 mg/kg/5 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests 		TOLED5 169,109,2007
unreported route
mouse 		lowest published toxic dose: 30 µg/kg/6 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Increase in cellular immune response 		TOXID9 72,376,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg(Hg)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.03 mg(Hg)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 58,239,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 58,239,1993
TOXICOLOGY REVIEW
CMAJAX 165,205,2001
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
NETOX* 26,483,2005
TOXICOLOGY REVIEW
NETOX* 26,511,2005
TOXICOLOGY REVIEW
NRTXDN 27,567,2006
TOXICOLOGY REVIEW
NETEEC 28,260,2006
TOXICOLOGY REVIEW
NETEEC 28,363,2006
TOXICOLOGY REVIEW
ENTOX* -,54,2005
TOXICOLOGY REVIEW
ENTOX* -,98,2005
TOXICOLOGY REVIEW
CRTXB2 36,609,2006
TOXICOLOGY REVIEW
CRTXB2 34,301,2004
TOXICOLOGY REVIEW
REPTED 23,260,2007
TOXICOLOGY REVIEW
REPTED 23,414,2007
TOXICOLOGY REVIEW
HBTME* ,213,2007
TOXICOLOGY REVIEW
HTOPA* 1,701,2002
TOXICOLOGY REVIEW
ITODC* -,327,2004
TOXICOLOGY REVIEW
HUTOX* -,515,1996
TOXICOLOGY REVIEW
TOLED5 182,48,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.001 ppm (0.01 mg(Hg)/m3) DTLWS* 3,22,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.01 mg(Hg)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.01 mg(Hg)/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.01 mg(Hg)/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.01 mg(Hg)/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.01 mg(Hg)/m3, short term exposure limit 0.03 mg(Hg)/m3, JUL2008
Occupational Exposure Limit - FINLAND time-weighted average 0.01 mg(Hg)/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.01 mg(Hg)/m3, Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.01 mg(Hg)/m3, short term exposure limit 0.03 mg(Hg)/m3, skin, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.01 mg(Hg)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.01 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.01 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg(Hg)/m3, MAC(short term exposure limit) 0.01 mg(Hg)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.2 mg(Hg)/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(Hg)/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 mg(Hg)/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.01 mg(Hg)/m3, short term exposure limit 0.04 mg(Hg)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.01 mg(Hg)/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HBTME*
HTOPA*
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
ITODC*
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NETOX* NeuroToxicology (Amsterdam : Elsevier Science) V.1- 1979-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
   Tumorigen
   Organometallic
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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