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Mercury chloride

RTECS #: OV8740000

CAS #: 10112-91-1


UPDATE: May 2009 MW: 472.08 MF: Cl2Hg2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Calogreen
  2. Calomel
  3. Calotab
  4. Chlorure mercureux (French)
  1. Cyclosan
  2. Dimercury dichloride
  3. Mercurous chloride
  4. Mercury subchloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster embryo 30 µmol/well /6 hour TIVIEQ 15,463,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 10 mg/kg N/R GTPZAB 25(7),27,1981
intraperitoneal
mouse
lowest published toxic dose: 11.8 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Renal function tests depressed
TOXID9 66,179,2002
oral
mouse
lethal dose (50 percent kill): 180 mg/kg N/R GTPZAB 25(7),27,1981
oral
mouse
lowest published toxic dose: 7.08 mg/kg Nutritional and Gross Metabolic: Changes in: Other metals FCTOD7 39,571,2001
oral
rat
lethal dose (50 percent kill): 210 mg/kg N/R PEMNDP 9,552,1991
oral
rat
lowest published toxic dose: 0.42 mg/kg Lung, Thorax, or Respiration: Respiratory depression TPKVAL 2,125,1961
subcutaneous
rat
lowest published toxic dose: 0.42 mg/kg N/R TPKVAL 2,125,1961
skin
rat
lethal dose (50 percent kill): 1,500 mg/kg N/R GTPZAB 25(7),27,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 17,640 µg/kg/7 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 68,218,1983
oral
mouse
lowest published toxic dose: 56.25 mg/kg/45 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Related to Chronic Data: Changes in testicular weight
REPTED 15,705,2001
oral
rat
lowest published toxic dose: 84 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GTPZAB 35(9),27,1991
oral
rat
lowest published toxic dose: 40.5 mg/kg/81 day- intermittent Skin: After systemic exposure: Dermatitis, other

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 39,73,2001
oral
rat
lowest published toxic dose: 81 mg/kg/81 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands FCTOD7 39,73,2001
oral
rat
lowest published toxic dose: 121.5 mg/kg/81 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 39,73,2001
oral
rat
lowest published toxic dose: 59.3 mg/kg/79 day- intermittent Skin: After systemic exposure: Dermatitis, other

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 39,73,2001
oral
rat
lowest published toxic dose: 197.5 mg/kg/79 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 39,73,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.025 mg(Hg)/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HBTME* ,675,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,262,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.003 ppm (0.025 mg(Hg)/m3), JUL2008
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg(Hg)/m3, skin, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.025 mg(Hg)/m3, JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.2 mg(Hg)/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.03 mg(Hg)/m3, Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Hg)/m3,KZG- week 0.8 mg(Hg)/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insecticide and fungicide
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTME*
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an insecticide and fungicide

RTECS Compound Description:
   Agricultural Chemical

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