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Registry of Toxic Effects of Chemical Substances (RTECS)

Mercury chloride

RTECS #

OV8740000

CAS #

10112-91-1

Updated

September 201

Molecular Weight

472.08

Molecular Formula

Cl2Hg2

Synonyms

Calogreen
Calomel
Calotab
Chlorure mercureux (French)
Cyclosan
Dimercury dichloride
Mercurous chloride
Mercury subchloride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisembryo/hamster30 µmol/well /6HTIVIEQ 15,463,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgGTPZAB 25(7),27,1981
intraperitoneal/mouse lowest published toxic dose: 11.8 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Renal function tests depressed
TOXID9 66,179,2002
oral/man lowest published lethal dose: 0.714 gm/kgBehavioral: Coma

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting
FSINDR 184,e1,2009
oral/mouse lethal dose (50 percent kill): 180 mg/kgGTPZAB 25(7),27,1981
oral/mouse lowest published toxic dose: 7.08 mg/kgNutritional and Gross Metabolic: Changes in: Other metalsFCTOD7 39,571,2001
oral/rat lethal dose (50 percent kill): 210 mg/kgPEMNDP 9,552,1991
oral/rat lowest published toxic dose: 0.042 mg/kgLung, Thorax, or Respiration: Respiratory depressionTPKVAL 2,125,1961
skin/rat lethal dose (50 percent kill): 1500 mg/kgGTPZAB 25(7),27,1981
subcutaneous/rat lowest published toxic dose: 0.042 mg/kgTPKVAL 2,125,1961

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 17640 µg/kg/7W- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXAPA9 68,218,1983
oral/mouse lowest published toxic dose: 56.25 mg/kg/45D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Related to Chronic Data: Changes in testicular weight
REPTED 15,705,2001
oral/rat lowest published toxic dose: 0.042 gm/kg/6W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 50,222,2012
oral/rat lowest published toxic dose: 84 mg/kg/12W- intermittentKidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GTPZAB 35(9),27,1991
oral/rat lowest published toxic dose: 40.5 mg/kg/81D- intermittentSkin: After systemic exposure: Dermatitis, other

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 39,73,2001
oral/rat lowest published toxic dose: 81 mg/kg/81D- intermittentReproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsFCTOD7 39,73,2001
oral/rat lowest published toxic dose: 121.5 mg/kg/81D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 39,73,2001
oral/rat lowest published toxic dose: 59.3 mg/kg/79D- intermittentSkin: After systemic exposure: Dermatitis, other

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 39,73,2001
oral/rat lowest published toxic dose: 197.5 mg/kg/79D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 39,73,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.025 mg(Hg)/m3 (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHBTME* ,675,2007
TOXICOLOGY REVIEWBLREV* 3,71,1989

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,262,1998
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.003 ppm (0.025 mg(Hg)/m3), JUL2008
Occupational Exposure Limit-FINLANDtime-weighted average 0.02 mg(Hg)/m3, skin, NOV2011
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Hg)/m3, skin, sen, 2011
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg(Hg)/m3, skin, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.025 mg(Hg)/m3, JAN2002
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.2 mg(Hg)/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.03 mg(Hg)/m3, Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.02 mg(Hg)/m3, KZG-week 0.16 mg(Hg)/m3, inhal, skin, sen, JAN2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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