CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Manganese, monosulfate, monohydrate

RTECS #: OP0893500

CAS #: 10034-96-5


UPDATE: May 2009 MW: 169.02 MF: O4S•Mn•H2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Manganese (II) sulfate monohydrate
  2. Manganese sulfate monohydrate
  3. Manganese (2+) sulfate monohydrate
  1. Manganous sulfate monohydrate
  2. Sulfuric acid, manganese (2+) salt (1:1) , monohydrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 180 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis oral
mouse
718 mg/kg/7 day- continuous MUREAV 240,159,1990
mutation in microorganisms Saccharomyes cerevisiae 40 µmol/L (-enzymatic activation step) MUREAV 137,47,1984
micronucleus test oral
mouse
205 mg/kg/24 hour- continuous MUREAV 240,159,1990
gene conversion and mitotic recombination Saccharomyes cerevisiae 40 µmol/L MUREAV 137,47,1984
sister chromatid exchange hamster ovary 5 mg/L EMMUEG 10(Suppl 10),1,1987
sperm morphology oral
mouse
513 mg/kg/5 day- continuous MUREAV 240,159,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 513 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 240,159,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,314 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors
NTPTR* NTP-TR-428,1993
oral
mouse
lowest published toxic dose: 1,297,800 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB94-217148
oral
mouse
lowest published toxic dose: 1,622,250 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB94-217148


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lowest published toxic dose: 2 mg/kg Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 148,41,2004
intravenous
mouse
lowest published toxic dose: 2 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 148,41,2004
intravenous
rat
lowest published toxic dose: 4.5 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOSCF2 73,378,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
monkey
lowest published toxic concentration: 4.62 mg/m3/6 hour/65 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOSCF2 92,201,2006
inhalation
monkey
lowest published toxic concentration: 4.62 mg/m3/6 hour/33 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases TOSCF2 92,201,2006
inhalation
monkey
lowest published toxic concentration: 4.62 mg/m3/6 hour/15 day- intermittent Blood: Other changes TOSCF2 92,201,2006
inhalation
rat
lowest published toxic concentration: 0.5 mg/m3/45 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 197,113,2004
inhalation
rat
lowest published toxic concentration: 0.1 mg/m3/90 day- intermittent Brain and Coverings: Changes in brain weight TXAPA9 197,113,2004
inhalation
rat
lowest published toxic concentration: 0.478 mg/m3/13 week- intermittent Olfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
INHTE5 16,481,2004
inhalation
rat
lowest published toxic concentration: 0.1 mg/m3/13 week- intermittent Brain and Coverings: Other degenerative changes INHTE5 16,481,2004
oral
mouse
lowest published toxic dose: 546 gm/kg/13 week- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Other changes
NTPTR* NTP-TR-428,1993
oral
rat
lowest published toxic dose: 42 gm/kg/14 day- continuous Liver: Changes in liver weight

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
NTPTR* NTP-TR-428,1993
oral
rat
lowest published toxic dose: 28,437 mg/kg/13 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-428,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (fume), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Mn)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m3 (respirable dust), APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 mg(Mn)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Mn)/m3;
short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit - MEXICO time-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg(Mn)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, MAC( continuous) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.2 mg(Mn)/m3, (total dust);
time-weighted average 0.1 mg(Mn)/m3, (resp.dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Mn)/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Mn)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1601;
Number of Industries 3;
Total Number of Facilities 60;
Number of Occupations 6;
Total Number of Employees Exposed 893;
Total Number of Female Employees Exposed 398


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us