Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Manganese, (ethylenebis(dithiocarbamato))-

RTECS #

OP0700000

CAS #

12427-38-2; 301-03-1; 11004-49-2; 12125-33-6; 20316-06-7; 28355-56-8; 133317-06-3

Updated

December 2013

Molecular Weight

265.30

Molecular Formula

C4H6N2S4·Mn

Synonyms

1,2-Ethanediylbis(carbamodithioato)(2-)-manganese
1,2-Ethanediylbiscarbamodithioic acid, manganese complex
1,2-Ethanediylbiscarbamodithioic acid, manganese(2+) salt (1:1)
1,2-Ethanediylbismaneb, manganese (2+) salt (1:1)
1,2-Ethylenediylbis(carbamodithioato)manganese
AAmangan
Agrox flowable
Agrox N-M
Akzo chemie maneb
BASF-maneb spritzpulver
Carbamic acid, ethylenebis(dithio-, manganese salt
Carbamodithioic acid, 1,2-ethanediylbis-, manganese complex
Chloroble M
Curzate M
Delsene M
Dithane M 22
Dithane M 22 special
ENT 14,875
Ethylenebis(dithiocarbamato), manganese
Ethylenebis(dithiocarbamic acid) manganous salt
Ethylenebis(dithiocarbamic acid), manganese salt
Ethylenebisdithiocarbamate manganese
F 10 (Pesticide)
Griffin manex
Kypman 80
Lonocol M
Luxan maneb 80
Maneb
Maneb 80
Maneb ZL4
Maneba
Manebe (French)
Manebe 80
Manebgan
Manesan
Manex
Mangaan (II)-(N,N'-ethyleen-bis(dithiocarbamaat)) (Dutch)
Mangan (II)-(N,N'-aethylen-bis(dithiocarbamate)) (German)
Mangan(II)-(N,N-aethylen-bis(dithiocarbamat)) (German)
Manganese (II) ethylene di(dithiocarbamate)
Manganese ethylene-1,2-bisdithiocarbamate
Manganous ethylenebis(dithiocarbamate)
Manganous ethylenebisdithiocarbamate
Manzate
Manzate D
Manzate maneb fungicide
N,N'-Ethylene bis(dithiocarbamate manganeux) (French)
N,N'-Etilen-bis(ditiocarbammato) di manganese (Italian)
Nereb
Nespor
Plantifog 160M
Polyram M
Remasan chloroble M
Rhodianebe
Trimangol
Trimangol 80
Tritogol M
Tubothane
Unicrop maneb
Vancide maneb 80

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster31 mg/LGMCRDC 27,95,1981
DNA inhibitionlymphocyte/human10 mg/LARTODN 45,101,1980
DNA inhibitionother cell types/rat10 mg/LARTODN 45,101,1980
gene conversion and mitotic recombination/Saccharomyes cerevisiae40 ppmNTIS** PB85-193761
gene conversion and mitotic recombinationoral/Drosophila melanogaster0.75 mmol/L/48HMUREAV 518,95,2002
mutation in microorganisms/Other microorganisms1000 ppm (-enzymatic activation step)MMAPAP 50,233,1973
mutation in microorganisms/Saccharomyes cerevisiae5 ppm (-enzymatic activation step)RSTUDV 6,161,1976
sister chromatid exchangeembryo/chicken14 gm/LMUREAV 206,271,1988
Unscheduled DNA Synthesisfibroblast/human10 mg/LNTIS** PB85-193761

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 15 mg/kg (15D after birth)Reproductive: Specific developmental abnormalities: Central nervous systemNRTXDN 23,621,2002
oral/rat 7440 mg/kg (7-22D preg/15D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
JTEHD6 5,821,1979
oral/rat 770 mg/kg (11D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Central nervous system
TJADAB 14,171,1976
oral/rat 770 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 14,171,1976
oral/rat 770 mg/kg (11D pregnant)Reproductive: Specific developmental abnormalities: HomeostasisTJADAB 14,171,1976
oral/rat 1420 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 14,171,1976
oral/rat 2500 mg/kg (6-22D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
TOLED5 99,91,1998
oral/mouse 3750 mg/kg (7-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJTEHD6 5,821,1979
oral/mouse 10 gm/kg (8-12D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TCMUD8 7,7,1987
oral/mouse 12 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 4,283,1990
unreported route/mouse 30 mg/kg (1-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 -,352,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 50 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970
oral/mouse lowest published toxic dose: 3600 mg/kg/5W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GISAAA 37(9),25,1972
oral/rat lowest published toxic dose: 62980 mg/kg/94W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
VPITAR 29,71,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 300 µmol/L/1HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
FCTOD7 49,1020,2011
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 50 µmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 49,1020,2011
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 100 µmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

Biochemical: Metabolism (intermediary): Lipids including transport

In Vitro Toxicity Studies: Other assays
FCTOD7 49,1020,2011
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: 200 µmol/L/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 49,1020,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 15 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NRTXDN 32,857,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 30 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.NRTXDN 32,857,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 30 µmol/L/48HIn Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
NRTXDN 32,857,2011
In Vitro/Human, neuroblastoma Inhibitor Concentration Low: 150 nmol/L/2WBiochemical: Metabolism (intermediary): Effect on mitochondrial functionNRTXDN 32,857,2011
intraperitoneal/rat lowest published toxic dose: 20 mg/kgEndocrine: Other changesATSUDG 8,253,1985
oral/guinea pig lowest published lethal dose: 6400 mg/kgPCOC** -,675,1966
oral/mouse lethal dose (50 percent kill): 2600 mg/kgGISAAA 36(5),22,1971
oral/rat lethal dose (50 percent kill): 3 gm/kgGISAAA 36(5),22,1971
skin/rat lethal dose (50 percent kill): >5 gm/kg85JFAN A252,1983
Tank with water/Daphnia lethal concentration (50 percent kill): 1 mg/L/48HAQUTO* 7,145,1985
Tank with water/Daphnia lethal concentration (50 percent kill): 111 µg/L/21DAQUTO* 7,165,1985
Tank with water/Guppy lethal concentration (50 percent kill): 3.7 mg/L/96HAQUTO* 7,145,1985
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 5 gm/kgGISAAA 45(5),29,1980
unreported route/quail lethal dose (50 percent kill): 467 mg/kgFMCHA2 -,C189,1991
unreported route/rat lethal dose (50 percent kill): 3 gm/kgEQSSDX 3,618,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 15 mg/kg/15D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NRTXDN 23,621,2002
intraperitoneal/mouse lowest published toxic dose: 915 mg/kg/45D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NRTXDN 23,621,2002
intraperitoneal/mouse lowest published toxic dose: 15 mg/kg/15D- intermittentBrain and Coverings: Other degenerative changesNRTXDN 23,621,2002
intraperitoneal/rat lowest published toxic dose: 90 mg/kg/12W- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Metabolism (intermediary): Other
ETOPFR 21,268,2006
intraperitoneal/rat lowest published toxic dose: 180 mg/kg/12W- intermittentBrain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
ETOPFR 21,268,2006
oral/rat lowest published toxic dose: 3750 mg/kg/3W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TIHEEC 22,395,2006
unreported route/mouse lowest published toxic dose: 14 mg/kg/14D- intermittentBiochemical: Metabolism (intermediary): Other

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 90,304,2006
unreported route/mouse lowest published toxic dose: 180 mg/kg/3W- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTSSA3* -,248,2003
unreported route/mouse lowest published toxic dose: 15 mg/kg/15D- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTSSA3* -,248,2003
unreported route/rat lowest published toxic dose: 150 mg/kg/3W- intermittentBehavioral: Change in psychophysiological testsTOXID9 66,318,2002

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,137,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 12,137,1976
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWCREOH* 42,25,2002
TOXICOLOGY REVIEWMUREAV 562,77,2004
TOXICOLOGY REVIEWREPTED 22,196,2006
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,86,2005
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,457,2007
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWHUTOX* -,561,1996
TOXICOLOGY REVIEWMUREAV 543,251,2003
TOXICOLOGY REVIEWTPHSDY 29,322,2008
TOXICOLOGY REVIEWMUREAV 674,73,2009
TOXICOLOGY REVIEWFEREAC 74,47507,2009
TOXICOLOGY REVIEWNEUCL* 23,485,2005
TOXICOLOGY REVIEWMUREAV 728,98,2011
TOXICOLOGY REVIEWMUREAV 728,98,2011
TOXICOLOGY REVIEWNRTXDN 32,383,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,129,1998
Mine Safety and Health Administration (MSHA) STANDARD-airceiling concentration 5 mg(Mn)/m3DTLVS* 3,149,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Mn)/m3;short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(Mn)/m3, JAN1993
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, JUN2003
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 mg(Mn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1785; Number of Industries 1; Total Number of Facilities 297; Number of Occupations 1; Total Number of Employees Exposed 593

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Weakly Positive: In vitro UDS-human fibroblast
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #107
TOP