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Manganese dioxide

RTECS #: OP0350000

CAS #: 1313-13-9


UPDATE: May 2009 MW: 86.94 MF: MnO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. BOG manganese
  2. Black manganese oxide
  3. Braunstein (German)
  4. Bruinsteen (Dutch)
  5. C.I. 77728
  6. C.I. Pigment Black 14
  7. C.I. Pigment Brown 8
  8. Cement Black
  9. Mangaanbioxyde (Dutch)
  10. Mangaandioxyde (Dutch)
  11. Mangandioxid (German)
  1. Manganese binoxide
  2. Manganese (biossido di) (Italian)
  3. Manganese (bioxyd de) (French)
  4. Manganese Black
  5. Manganese (diossido di) (Italian)
  6. Manganese peroxide
  7. Manganese superoxide
  8. Manganese (dioxyde de) (French)
  9. Manganese (IV) oxide
  10. Pyrolusite Brown


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 49 mg/m3/7 hour (75 day prior to copulation/1-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
FEPRA7 39,623,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratracheal
rat
lowest published lethal dose: 50 mg/kg Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema
GISAAA 20(1),25,1955
intravenous
rabbit
lowest published lethal dose: 45 mg/kg N/R 85KYAH 11,899,1989
oral
rat
lethal dose (50 percent kill): 3,478 mg/kg N/R USXXAM #6441582
subcutaneous
mouse
lethal dose (50 percent kill): 422 mg/kg N/R ZVKOA6 19,186,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
man
lowest published toxic concentration: 0.66 mg/m3/14 year- intermittent Brain and Coverings: Recordings from specific areas of CNS NRTXDN 28,126,2007
inhalation
monkey
lowest published toxic concentration: 0.6 mg/m3/1 hour/17 week- intermittent Behavioral: Tremor

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)
VCVN5* -,411,1989
inhalation
rat
lowest published toxic concentration: 1,800 g/m3/24 hour/35 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 49(12),53,1984
inhalation
rat
lowest published toxic concentration: 7 mg/m3/24 hour/34 week- continuous Behavioral: Alteration of classical conditioning VCVN5* -,411,1989
intramuscular
human
lowest published toxic dose: 21 g/m3/5.3 year- intermittent Behavioral: Change in psychophysiological tests

Nutritional and Gross Metabolic: Changes in: Fe
BJIMAG 49,25,1992
subcutaneous
monkey
lowest published toxic dose: 150 mg/kg/3 week- intermittent Behavioral: Change in motor activity (specific assay) VCVN5* -,411,1989
subcutaneous
mouse
lowest published toxic dose: 6,000 mg/kg/12 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,411,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AMRL** TR-73-125,1973
TOXICOLOGY REVIEW
85DHAX Mn,1,1973
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
JTEHF8 70,594,2007
TOXICOLOGY REVIEW
HBTME* ,177,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 5 mg(Mn)/m3 DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (fume), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Mn)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m3 (respirable dust), APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 mg(Mn)/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Mn)/m3;
short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit - MEXICO time-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg(Mn)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, MAC( continuous) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.2 mg(Mn)/m3, (total dust);
time-weighted average 0.1 mg(Mn)/m3, (resp.dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Mn)/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Mn)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 44030;
Number of Industries 48;
Total Number of Facilities 3,820;
Number of Occupations 60;
Total Number of Employees Exposed 53,685
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 44030;
Number of Industries 41;
Total Number of Facilities 3,347;
Number of Occupations 50;
Total Number of Employees Exposed 71,963;
Total Number of Female Employees Exposed 15,526


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as depolarizer for dry cell batteries, also used for production of manganese metal
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva. Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-

Used as depolarizer for dry cell batteries, also used for production of manganese metal

NIOSH PROFILE (IRON AND STEEL FOUNDRIES), SRC, 14/77

NIOSH PROFILE (MANGANESE AND ITS COMPOUNDS), SRC, 4/82

RTECS Compound Description:
   Reproductive Effector
   Human Data

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