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Registry of Toxic Effects of Chemical Substances (RTECS)

Malonic acid

RTECS #

OO0175000

CAS #

141-82-2

Updated

February 2009

Molecular Weight

104.07

Molecular Formula

C3H4O4

Synonyms

Carboxyacetic acid
Dicarboxymethane
Kyselina malonova (Czech)
Methanedicarboxylic acid
Propanedioic acid
USAF EK-695

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformoral/rat10080 mg/kg/6WCRNGDP 9,387,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intracerebral/rat lowest published toxic dose: 531 ng/kgBrain and Coverings: Other degenerative changesEJPHAZ 505,111,2004
intraperitoneal/mouse lethal dose (50 percent kill): 300 mg/kgNTIS** AD277-689
intraperitoneal/rat lowest published toxic dose: 500 mg/kgEndocrine: Aldosteronism

Endocrine: Other changes
EKFAE9 55,56,1992
intraperitoneal/rat lethal dose (50 percent kill): 1500 mg/kg38MKAJ 2C,4937,1982
oral/mouse lethal dose (50 percent kill): 4 gm/kgTumorigenic: Active as anti-cancer agentBIJOAK 34,1196,1940

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 659,31,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4746; Number of Industries 2; Total Number of Facilities 46; Number of Occupations 3; Total Number of Employees Exposed 1913; Total Number of Female Employees Exposed 272

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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