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Magnesium sulfate (1:1)

RTECS #: OM4500000

CAS #: 7487-88-9


UPDATE: May 2009 MW: 120.37 MF: O4SMg


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Epsom salts
  2. Magnesium sulfate
  1. Magnesium sulphate
  2. Sulfuric acid magnesium salt (1:1)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
gene conversion and mitotic recombination Escherichia coli 5 pph JGMIAN 8,45,1953
phage inhibition capacity Escherichia coli 800 mol/L ENMUDM 6,59,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 750 mg/kg (17-21 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Hepatobiliary system
GEPHDP 12,25,1981
intravenous
woman
lowest published toxic dose: 320 mg/kg (39 week pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
AJOGAH 168,1170,1993
subcutaneous
rat
lowest published toxic dose: 9 gm/kg (15-20 day pregnant) Reproductive: Other effects on female JTSCDR 23(Suppl 1),67,1998
subcutaneous
rat
lowest published toxic dose: 18 gm/kg (15-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
JTSCDR 23(Suppl 1),67,1998
unreported route
rat
lowest published toxic dose: 750 mg/kg (17-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death VCVN1* -,105,1988


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraduodenal
dog
lowest published toxic dose: 482 mg/kg/1 hour Gastrointestinal: Alteration in gastric secretion AJPHAP 248,G28,1985
intraperitoneal
dog
lowest published lethal dose: 1,200 mg/kg N/R HBAMAK 4,1364,1935
intraperitoneal
mouse
lethal dose (50 percent kill): 150 mg/kg N/R VCVN1* -,104,1988
intraperitoneal
mouse
lowest published toxic dose: 1,000 mg/kg Brain and Coverings: Other degenerative changes JTCTDW 41,749,2003
intraperitoneal
rat
lowest published toxic dose: 500 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation INJPD2 38,397,2006
intraspinal
woman
lowest published toxic dose: 20 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia SAMJAF 68,367,1985
intraspinal
woman
lowest published toxic dose: 200 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Gastrointestinal: Decreased motility or constipation

Kidney, Ureter, and Bladder: Other changes
JTCTDW 42,732,2004
intravenous
dog
lowest published toxic dose: 30.1 mg/kg/15 minute Gastrointestinal: Alteration in gastric secretion AJPHAP 248,G28,1985
intravenous
dog
lowest published toxic dose: 5,754 g/kg Vascular: Other changes

Lung, Thorax, or Respiration: Other changes
AANEAB 45,435,2001
intravenous
dog
lowest published toxic dose: 12 mg/kg Cardiac: Cardiac output AANEAB 45,435,2001
intravenous
dog
lowest published toxic dose: 120 mg/kg Vascular: BP lowering not characterized in autonomic section

Cardiac: Change in rate
AANEAB 45,435,2001
intravenous
domestic animal
lowest published toxic dose: 72 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Vascular: Measurement of regional blood flow
JPETAB 297,1176,2001
intravenous
human
lowest published lethal dose: 10.5 mg/kg N/R TOXID9 60,13,2001
intravenous
mouse
lowest published lethal dose: 48 mg/kg N/R TXAPA9 4,492,1962
intravenous
pig
lowest published toxic dose: 18,056 g/kg Cardiac: Arrythmias (indlucing changes in conduction) TOXID9 60,13,2001
intravenous
woman
lowest published lethal dose: 80 mg/kg/2 minute- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Cyanosis
SAMJAF 67,145,1985
oral
man
lowest published toxic dose: 428 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Other changes
JJTOEX 2,285,1989
oral
mouse
lowest published lethal dose: 5 gm/kg N/R HBAMAK 4,1364,1935
oral
mouse
lowest published toxic dose: 2 gm/kg Gastrointestinal: Hypermotility, diarrhea INJPD2 39,245,2007
oral
mouse
lowest published toxic dose: 2 gm/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
FTRPAE 75,39,2004
oral
rat
lowest published toxic dose: 1 gm/kg Vascular: BP lowering not characterized in autonomic section

Endocrine: Hypoglycemia
CEXPB9 32,604,2005
oral
rabbit
lowest published lethal dose: 3 gm/kg N/R HBAMAK 4,1364,1935
oral
woman
lowest published toxic dose: 351 mg/kg Behavioral: Muscle weakness

Cardiac: Arrythmias (indlucing changes in conduction)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTCTDW 34,735,1996
subcutaneous
cat
lowest published lethal dose: 1 gm/kg Behavioral: General anesthetic AJPHAP 14,366,1905
subcutaneous
dog
lowest published lethal dose: 1,500 mg/kg N/R HBAMAK 4,1364,1935
subcutaneous
guinea pig
lowest published lethal dose: 1,800 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
AJPHAP 14,366,1905
subcutaneous
mouse
lethal dose (50 percent kill): 645 mg/kg N/R CYLPDN 7,178,1986
subcutaneous
rat
lethal dose (50 percent kill): 1,200 mg/kg N/R NELED5 117,207,1990
subcutaneous
rabbit
lowest published lethal dose: 1,750 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
AJPHAP 14,366,1905


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 56 gm/kg/8 week- intermittent Vascular: BP lowering not characterized in autonomic section

Vascular: Structural changes in vessels

Endocrine: Hypoglycemia
CEXPB9 32,604,2005
unreported route
rat
lowest published toxic dose: 750 mg/kg/5 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
VCVN1* -,105,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
AJEMEN 18,216,2000
TOXICOLOGY REVIEW
HUTOX* -,301,1996
TOXICOLOGY REVIEW
HUTOX* -,473,1996
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,320,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 43410;
Number of Industries 88;
Total Number of Facilities 11,060;
Number of Occupations 80;
Total Number of Employees Exposed 106,080
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 43410;
Number of Industries 111;
Total Number of Facilities 13,961;
Number of Occupations 95;
Total Number of Employees Exposed 235,005;
Total Number of Female Employees Exposed 108,074


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in food, pharmaceutical, and photo applications
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AJPHAP American Journal of Physiology. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1898-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947-
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HTOPA*
HUTOX*
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
NELED5 Neuroscience Letters. (Elsevier Scientific Publishers Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used in food, pharmaceutical, and photo applications

FDA-over the counter and proprietary drug

RTECS Compound Description:
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   Mutagen
   Reproductive Effector
   Human Data
   Hormone

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