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Registry of Toxic Effects of Chemical Substances (RTECS)

Magnesium sulfate (1:1)

RTECS #

OM4500000

CAS #

7487-88-9

Updated

December 2010

Molecular Weight

120.37

Molecular Formula

O4S·Mg

Synonyms

Epsom salts
Magnesium sulfate
Magnesium sulphate
Sulfuric acid magnesium salt (1:1)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
gene conversion and mitotic recombination/Escherichia coli5 pphJGMIAN 8,45,1953
phage inhibition capacity/Escherichia coli800 µmol/LENMUDM 6,59,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 750 mg/kg (17-21D pregnant)Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Hepatobiliary system
GEPHDP 12,25,1981
intravenous/woman 320 mg/kg (39W pregnant)Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
AJOGAH 168,1170,1993
subcutaneous/rat 9 gm/kg (15-20D pregnant)Reproductive: Other effects on femaleJTSCDR 23(Suppl 1),67,1998
subcutaneous/rat 18 gm/kg (15-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
JTSCDR 23(Suppl 1),67,1998
unreported route/rat 750 mg/kg (17-21D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathVCVN1* -,105,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraduodenal/Dog lowest published toxic dose: 482 mg/kg/1HGastrointestinal: Alteration in gastric secretionAJPHAP 248,G28,1985
intraperitoneal/Dog lowest published lethal dose: 1200 mg/kgHBAMAK 4,1364,1935
intraperitoneal/mouse lowest published toxic dose: 1000 mg/kgBrain and Coverings: Other degenerative changesJTCTDW 41,749,2003
intraperitoneal/mouse lethal dose (50 percent kill): 150 mg/kgVCVN1* -,104,1988
intraperitoneal/rat lowest published toxic dose: 500 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationINJPD2 38,397,2006
intraspinal/woman lowest published toxic dose: 200 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Gastrointestinal: Decreased motility or constipation

Kidney, Ureter, and Bladder: Other changes
JTCTDW 42,732,2004
intraspinal/woman lowest published toxic dose: 20 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesiaSAMJAF 68,367,1985
intravenous/Dog lowest published toxic dose: 5754 µg/kgVascular: Other changes

Lung, Thorax, or Respiration: Other changes
AANEAB 45,435,2001
intravenous/Dog lowest published toxic dose: 12 mg/kgCardiac: Cardiac outputAANEAB 45,435,2001
intravenous/Dog lowest published toxic dose: 120 mg/kgVascular: BP lowering not characterized in autonomic section

Cardiac: Change in rate
AANEAB 45,435,2001
intravenous/Dog lowest published toxic dose: 30.1 mg/kg/15MGastrointestinal: Alteration in gastric secretionAJPHAP 248,G28,1985
intravenous/domestic animal lowest published toxic dose: 72 mg/kgCardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Vascular: Measurement of regional blood flow
JPETAB 297,1176,2001
intravenous/human lowest published lethal dose: 10.5 mg/kgTOXID9 60,13,2001
intravenous/mouse lowest published lethal dose: 48 mg/kgTXAPA9 4,492,1962
intravenous/pig lowest published toxic dose: 18056 µg/kgCardiac: Arrythmias (indlucing changes in conduction)TOXID9 60,13,2001
intravenous/woman lowest published lethal dose: 80 mg/kg/2M- intermittentCardiac: Other changes

Lung, Thorax, or Respiration: Cyanosis
SAMJAF 67,145,1985
oral/man lowest published toxic dose: 428 mg/kgBehavioral: Muscle weakness

Lung, Thorax, or Respiration: Other changes
JJTOEX 2,285,1989
oral/mouse lowest published lethal dose: 5 gm/kgHBAMAK 4,1364,1935
oral/mouse lowest published toxic dose: 2 gm/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
FTRPAE 75,39,2004
oral/mouse lowest published toxic dose: 2 gm/kgGastrointestinal: Hypermotility, diarrheaPYTOEY 12,670,2005
oral/rabbit lowest published lethal dose: 3 gm/kgHBAMAK 4,1364,1935
oral/rat lowest published toxic dose: 1 gm/kgVascular: BP lowering not characterized in autonomic section

Endocrine: Hypoglycemia
CEXPB9 32,604,2005
oral/woman lowest published toxic dose: 351 mg/kgBehavioral: Muscle weakness

Cardiac: Arrythmias (indlucing changes in conduction)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
JTCTDW 34,735,1996
subcutaneous/cat lowest published lethal dose: 1 gm/kgBehavioral: General anestheticAJPHAP 14,366,1905
subcutaneous/Dog lowest published lethal dose: 1500 mg/kgHBAMAK 4,1364,1935
subcutaneous/guinea pig lowest published lethal dose: 1800 mg/kgBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)
AJPHAP 14,366,1905
subcutaneous/mouse lethal dose (50 percent kill): 645 mg/kgCYLPDN 7,178,1986
subcutaneous/rabbit lowest published lethal dose: 1750 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes
AJPHAP 14,366,1905
subcutaneous/rat lethal dose (50 percent kill): 1200 mg/kgNELED5 117,207,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 56 gm/kg/8W- intermittentVascular: BP lowering not characterized in autonomic section

Vascular: Structural changes in vessels

Endocrine: Hypoglycemia
CEXPB9 32,604,2005
unreported route/rat lowest published toxic dose: 750 mg/kg/5D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
VCVN1* -,105,1988

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAJEMEN 18,216,2000
TOXICOLOGY REVIEWHUTOX* -,301,1996
TOXICOLOGY REVIEWHUTOX* -,473,1996
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWPTPAD4 120,43,2008
TOXICOLOGY REVIEWJFSCAS 10,91,1970
TOXICOLOGY REVIEWNBREV* 5,1,1981

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,320,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 43410; Number of Industries 111; Total Number of Facilities 13961; Number of Occupations 95; Total Number of Employees Exposed 235005; Total Number of Female Employees Exposed 108074
National Occupational Hazard Survey 1974Hazard Code 43410; Number of Industries 88; Total Number of Facilities 11060; Number of Occupations 80; Total Number of Employees Exposed 106080

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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