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Registry of Toxic Effects of Chemical Substances (RTECS)

Magnesium chloride

RTECS #

OM2800000

CAS #

7786-30-3

Updated

December 2010

Molecular Weight

95.21

Molecular Formula

Cl2Mg

Synonyms

DUS-top

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic AnalysisHeLa cell/human2 mmol/LJCLLAX 78,217,1971
DNA Damagefibroblast/human20 mmol/LMUREAV 193,237,1988
mutation in microorganisms/Other microorganisms8000 ppm (-enzymatic activation step)APMBAY 6,45,1958
other mutation test systemsAscites tumor/mouse4 mmol/LAMOKAG 33,141,1979
Unscheduled DNA Synthesisintraperitoneal/rat2500 µmol/kgJOENAK 65,45,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intramuscular/mammal (species unspecified) lethal dose (50 percent kill): 1 gm/kgFATOBP 9,113,1974
intraperitoneal/mouse lethal dose (50 percent kill): 342 mg/kgCOREAF 256,1043,1963
intraperitoneal/mouse lowest published toxic dose: 0.5 gm/kgBehavioral: General anesthetic

Behavioral: Anticonvulsant
PBBHAU 21,17,1984
intraperitoneal/rat lowest published toxic dose: 30 mg/kgBehavioral: Alteration of classical conditioningPHREP* 57,654,2005
intraperitoneal/rat lethal dose (50 percent kill): 760 mg/kgVCVN1* -,104,1988
intraperitoneal/rat lowest published lethal dose: 225 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
JPETAB 35,1,1929
intraspinal/rat lowest published toxic dose: 77.96 µg/kgBehavioral: AnalgesiaBJMRDK 35,395,2002
intravenous/Dog lowest published lethal dose: 229 mg/kgCardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 1,1,1909
intravenous/mouse lethal dose (50 percent kill): 14 mg/kgTXAPA9 22,150,1972
oral/mouse lethal dose (50 percent kill): 4700 mg/kgIYKEDH 21,257,1990
oral/rat lethal dose (50 percent kill): 2800 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
JPETAB 35,1,1929
subcutaneous/rabbit lowest published toxic dose: 1 mg/kgEndocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN1* -,104,1988
subcutaneous/rat lowest published lethal dose: 900 mg/kgBehavioral: Somnolence (general depressed activity)ENDOAO 24,523,1939

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 420 mg/kg/14D- intermittentBehavioral: TolerancePHREP* 57,654,2005
oral/mouse lowest published toxic dose: 114 mg/kg/13W- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight
JTSCDR 9,291,1984

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWNBREV* 11,35,1987

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,317,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 43360; Number of Industries 89; Total Number of Facilities 8597; Number of Occupations 99; Total Number of Employees Exposed 258526; Total Number of Female Employees Exposed 138531
National Occupational Hazard Survey 1974Hazard Code 43360; Number of Industries 44; Total Number of Facilities 2931; Number of Occupations 37; Total Number of Employees Exposed 37111

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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