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Magnesium chloride

RTECS #: OM2800000

CAS #: 7786-30-3


UPDATE: November 2008 MW: 95.21 MF: Cl2Mg


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. DUS - top


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human HeLa cell 2 mmol/L JCLLAX 78,217,1971
DNA damage human fibroblast 20 mmol/L MUREAV 193,237,1988
unscheduled DNA synthesis intraperitoneal
rat
2,500 µmol/kg JOENAK 65,45,1975
mutation in microorganisms other microorganisms 8,000 ppm (-enzymatic activation step) APMBAY 6,45,1958
other mutation test systems mouse Ascites tumor 4 mmol/L AMOKAG 33,141,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
mammal (species unspecified)
lethal dose (50 percent kill): 1 gm/kg N/R FATOBP 9,113,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 342 mg/kg N/R COREAF 256,1043,1963
intraperitoneal
mouse
lowest published toxic dose: 0.5 gm/kg Behavioral: General anesthetic

Behavioral: Anticonvulsant
PBBHAU 21,17,1984
intraperitoneal
rat
lowest published lethal dose: 225 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
JPETAB 35,1,1929
intraperitoneal
rat
lethal dose (50 percent kill): 760 mg/kg N/R VCVN1* -,104,1988
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg Behavioral: Alteration of classical conditioning PHREP* 57,654,2005
intraspinal
rat
lowest published toxic dose: 77.96 µg/kg Behavioral: Analgesia BJMRDK 35,395,2002
intravenous
dog
lowest published lethal dose: 229 mg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 1,1,1909
intravenous
mouse
lethal dose (50 percent kill): 14 mg/kg N/R TXAPA9 22,150,1972
oral
mouse
lethal dose (50 percent kill): 4,700 mg/kg N/R IYKEDH 21,257,1990
oral
rat
lethal dose (50 percent kill): 2,800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
JPETAB 35,1,1929
subcutaneous
rat
lowest published lethal dose: 900 mg/kg Behavioral: Somnolence (general depressed activity) ENDOAO 24,523,1939
subcutaneous
rabbit
lowest published toxic dose: 1 mg/kg Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVN1* -,104,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 420 mg/kg/14 day- intermittent Behavioral: Tolerance PHREP* 57,654,2005
oral
mouse
lowest published toxic dose: 114 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight
JTSCDR 9,291,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,317,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 43360;
Number of Industries 44;
Total Number of Facilities 2,931;
Number of Occupations 37;
Total Number of Employees Exposed 37,111
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 43360;
Number of Industries 89;
Total Number of Facilities 8,597;
Number of Occupations 99;
Total Number of Employees Exposed 258,526;
Total Number of Female Employees Exposed 138,531


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to control dust and stabilize dirt roads, in food and pharmaceutical applications
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AMOKAG Acta Medicia Okayama. (Okayama Univ. Medical School, Okayama, Japan) V.27 1973-
APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF.
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
PHREP*
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used to control dust and stabilize dirt roads, in food and pharmaceutical applications

FDA-proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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