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Lithium carbonate (2:1)

[Oxytropis sericea]

RTECS #: OJ5800000

CAS #: 554-13-2


UPDATE: February 2009 MW: 73.89 MF: CO32Li


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. CP - 15467 - 61
  2. Camcolit
  3. Candamide
  4. Carbolith
  5. Carbolithium
  6. Carbonic acid lithium salt
  7. Carbonic acid, dilithium salt
  8. Ceglution
  9. Dilithium carbonate
  10. Eskalith
  11. Hypnorex
  12. Limas
  13. Liskonum
  1. Lithane
  2. Lithicarb
  3. Lithinate
  4. Lithium carbonate
  5. Lithobid
  6. Lithonate
  7. Lithotabs
  8. NSC - 16895
  9. Plenur
  10. Priadel
  11. Quilonum retard
  12. Teralithe (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis unreported route
human
12,800 g/kg/12 week- intermittent TJADAB 13,131,1976
cytogenetic analysis oral
mouse
1,200 g/kg/3 day- intermittent CYTOAN 54,245,1989
DNA damage human fibroblast 500 mg/L MUREAV 169,171,1986
DNA inhibition human fibroblast 2 gm/L MUREAV 169,171,1986
DNA inhibition oral
rat
420 gm/kg/12 week- continuous MUREAV 244,331,1990
mutation in mammalian somatic cells hamster lung 2 gm/L MUREAV 169,171,1986
sister chromatid exchange oral
mouse
1,200 g/kg/3 day- intermittent CYTOAN 54,245,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 42 mg/kg (60 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 56ZJAL 4,423,1996
intraperitoneal
mouse
lowest published toxic dose: 40 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NNAPBA 270,56,1971
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 26,239,1982
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 26,239,1982
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
ARTODN 71,519,1997
oral
mouse
lowest published toxic dose: 4,650 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
NATUAS 225,73,1970
oral
mouse
lowest published toxic dose: 4,650 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TXAPA9 17,274,1970
oral
mouse
lowest published toxic dose: 2 gm/kg (8-12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) JTEHD6 10,541,1982
oral
mouse
lowest published toxic dose: 600 mg/kg (7-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Sex ratio
KSRNAM 7,1736,1973
oral
pig
lowest published toxic dose: 240 gm/kg (36-115 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)
PSEBAA 158,123,1978
oral
pig
lowest published toxic dose: 240 gm/kg (36-115 day pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects PSEBAA 158,123,1978
oral
rat
lowest published toxic dose: 600 mg/kg (9-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system KSRNAM 7,1736,1973
oral
rat
lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOLED5 34,115,1986
oral
rat
lowest published toxic dose: 1,050 mg/kg (1-21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTRSDC 10,315,1990
oral
rat
lowest published toxic dose: 1,050 mg/kg (21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTRSDC 10,315,1990
oral
rat
lowest published toxic dose: 1.52 gm/kg (1-19 day pregnant) Reproductive: Other developmental abnormalities FATOAO 48,73,1985
oral
rat
lowest published toxic dose: 800 mg/kg (15-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FATOAO 46,108,1983
oral
rat
lowest published toxic dose: 1,120 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FATOAO 46,108,1983
oral
rat
lowest published toxic dose: 1,120 mg/kg (8-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death FATOAO 46,108,1983
oral
rat
lowest published toxic dose: 1,520 mg/kg (1-19 day pregnant) Reproductive: Effects on newborn: Behavioral FATOAO 48,73,1985
oral
rat
lowest published toxic dose: 33 gm/kg (30 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) REPTED 17,683,2003
oral
woman
lowest published toxic dose: 3,072 mg/kg (1-37 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects JOPDAB 81,804,1972
oral
woman
lowest published toxic dose: 4,900 mg/kg (1-35 week pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system LANCAO 2,595,1974
oral
woman
lowest published toxic dose: 4,256 mg/kg (1-38 week pregnant) Reproductive: Effects on newborn: Apgar score (human only)

Reproductive: Effects on newborn: Other neonatal measures or effects
BMJOAE 3,233,1973
oral
woman
lowest published toxic dose: 10,080 mg/kg (26 week prior to copulation-34 week pregnant) Reproductive: Effects on newborn: Stillbirth BJPYAJ 154,114,1989
unreported route
mouse
lowest published toxic dose: 4,650 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) LANCAO 2,849,1969
unreported route
woman
lowest published toxic dose: 540 mg/kg (35-39 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects PEDIAU 47,94,1971
unreported route
woman
lowest published toxic dose: 556 mg/kg (30-34 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects JAMAAP 213,865,1970
unreported route
woman
lowest published toxic dose: 11,520 mg/kg (7 week prior to copulation/1-38 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system
CMAJAX 105,847,1971
unreported route
woman
lowest published toxic dose: 11,520 mg/kg (7 week prior to copulation/1-38 week pregnant) Reproductive: Effects on newborn: Apgar score (human only)

Reproductive: Effects on newborn: Other neonatal measures or effects
CMAJAX 105,847,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
man
toxic dose : 6,132 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
HAEMAX 67,944,1982
oral
rat
lowest published toxic dose: 5,687.5 mg/kg/91 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Facilitates action of known carcinogens
VOONC* -,1309,1992
oral
woman
lowest published toxic dose: 3,600 mg/kg/21 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
NEJMAG 302,808,1980
oral
woman
toxic dose : 21 gm/kg/3.5 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors
ANZJB8 10,62,1980
oral
woman
toxic dose : 5,940 mg/kg/47 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
AIMEAS 92,262,1980


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 236 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Excitement

Behavioral: Ataxia
KSRNAM 7,1273,1973
intraperitoneal
mouse
lethal dose (50 percent kill): 360 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction)
VCVN1* -,25,1998
intraperitoneal
rat
lethal dose (50 percent kill): 156 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
KSRNAM 7,1273,1973
intraperitoneal
rat
lethal dose (50 percent kill): 290 mg/kg N/R FATOAO 48,73,1985
intraperitoneal
rat
lowest published toxic dose: 88.8 mg/kg Brain and Coverings: Other degenerative changes FATOAO 47,11,1984
intraperitoneal
rat
lowest published toxic dose: 88 mg/kg Behavioral: Antipsychotic FATOAO 47,11,1984
intraperitoneal
rat
lethal dose (16 percent kill): 168 mg/kg N/R TOVEFN (4),29,1996
intraperitoneal
rat
lethal dose : 425 mg/kg N/R TOVEFN (4),29,1996
intravenous
mouse
lethal dose (50 percent kill): 497 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression
KSRNAM 7,1273,1973
intravenous
rat
lethal dose (50 percent kill): 241 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Lung, Thorax, or Respiration: Respiratory depression
KSRNAM 7,1273,1973
oral
dog
lethal dose (50 percent kill): 500 mg/kg N/R 27ZQAG -,436,1972
oral
human
lowest published toxic dose: 4,111 mg/kg Behavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Other changes
NEJMAG 287,867,1972
oral
man
lowest published toxic dose: 25 gm/kg/4 year- intermittent Behavioral: Tremor

Eye: Miosis (pupilliary constriction)
JCLPDE 46,292,1985
oral
man
lowest published toxic dose: 8 mg/kg Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other
AJPSAO 141,909,1984
oral
man
lowest published toxic dose: 54 mg/kg Behavioral: Sleep

Behavioral: Hallucinations, distorted perceptions
NZMJAX 97,23,1984
oral
man
lowest published toxic dose: 1,080 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, allergic JCLPDE 47,330,1986
oral
man
lowest published toxic dose: 128.6 mg/kg Behavioral: Tremor

Cardiac: Change in rate
JEMME* 10,719,1992
oral
man
lowest published toxic dose: 114.3 mg/kg Gastrointestinal: Nausea or vomiting ERPSY* 14,172,1999
oral
mouse
lethal dose (50 percent kill): 531 mg/kg N/R RPTOAN 33,266,1970
oral
mouse
lethal dose (50 percent kill): 531 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction)
VCVN1* -,25,1998
oral
mouse
lowest published toxic dose: 10 mg/kg Behavioral: Change in psychophysiological tests EJPHAZ 553,157,2006
oral
rat
lethal dose (50 percent kill): 525 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Hypermotility, diarrhea
KSRNAM 7,1273,1973
oral
rat
lethal dose (50 percent kill): 553 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction)
VCVN1* -,25,1998
oral
rat
lethal dose (50 percent kill): 770 mg/kg N/R TOVEFN (4),29,1996
oral
rat
lethal dose (16 percent kill): 552 mg/kg N/R TOVEFN (4),29,1996
oral
rat
lethal dose : 985 mg/kg N/R TOVEFN (4),29,1996
oral
rabbit
lethal dose (50 percent kill): 404 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction)
VCVN1* -,25,1998
oral
woman
lowest published toxic dose: 36,500 mg/kg/10 year- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume increased

Endocrine: Diabetes insipidus (nephrogenic or CNS)
AMDIBO 148,284,1997
oral
woman
lowest published toxic dose: 612 mg/kg/44 day- intermittent Behavioral: Sleep

Skin: After systemic exposure: Dermatitis, allergic
AJPSAO 152,956,1995
oral
woman
lowest published toxic dose: 8,760 mg/kg/2 year- intermittent Endocrine: Thyroid weight (goiter)

Endocrine: Evidence of thyroid hyperfunction
AJMEAZ 99,575,1995
oral
woman
lowest published toxic dose: 120 mg/kg/10 day- intermittent Behavioral: Excitement JCLPDE 48,81,1987
oral
woman
lowest published toxic dose: 90 mg/kg Behavioral: Tremor

Nutritional and Gross Metabolic: Body temperature increase
JEMME* 10,719,1992
subcutaneous
frog
lethal dose (50 percent kill): 452 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction)
VCVN1* -,25,1998
subcutaneous
mouse
lethal dose (50 percent kill): 413 mg/kg N/R RPTOAN 33,266,1970
subcutaneous
mouse
lethal dose (50 percent kill): 413 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Tetany

Cardiac: Arrythmias (indlucing changes in conduction)
VCVN1* -,25,1998
subcutaneous
rat
lethal dose (50 percent kill): 434 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Skin and Appendages: Other: Hair
KSRNAM 7,1273,1973
unreported route
woman
lowest published toxic dose: 556 mg/kg/32 day Behavioral: Toxic psychosis JAMAAP 213,865,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 600 mg/kg/60 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) AJANA2 134,97,1972
intraperitoneal
rat
lowest published toxic dose: 1,600 mg/kg/80 day- intermittent Endocrine: Changes in thyroid weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AJANA2 136,297,1973
intraperitoneal
rat
lowest published toxic dose: 1,600 mg/kg/80 day- intermittent Behavioral: Sleep

Gastrointestinal: Hypermotility, diarrhea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AJANA2 136,297,1973
oral
child
lowest published toxic dose: 210 mg/kg/7 day- intermittent Biochemical: Metabolism (intermediary): Other carbohydrates NEROEW 24,359,2001
oral
mammal (species unspecified)
lowest published toxic dose: 14,560 g/kg/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Liver: Liver function tests impaired

Blood: Pigmented or nucleated red blood cells
STGNBT -,155,1999
oral
man
lowest published toxic dose: 62,561 mg/kg/10 year- intermittent Brain and Coverings: Changes in circulation

Nutritional and Gross Metabolic: Changes in: Na

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTCTDW 41,359,2003
oral
mouse
lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse NTPTR* IMM-85001
oral
mouse
lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Endocrine: Other changes
NTPTR* IMM-85001
oral
mouse
lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-85001
oral
mouse
lowest published toxic dose: 5,600 mg/kg/14 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count
NTPTR* IMM-85001
oral
mouse
lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Uncharacterized (multiple organ involvement)
NTPTR* IMM-85001
oral
mouse
lowest published toxic dose: 4,200 mg/kg/14 day- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decreased immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
NTPTR* IMM-85001
oral
rat
lowest published toxic dose: 4,500 mg/kg/30 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
KSRNAM 7,1278,1973
oral
rat
lowest published toxic dose: 18,200 mg/kg/26 week- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
KSRNAM 7,12,1973
oral
rat
lowest published toxic dose: 36,400 mg/kg/52 week- intermittent Cardiac: Changes in heart weight

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
KSRNAM 7,12,1973
oral
rat
lowest published toxic dose: 1,980 mg/kg/30 day- continuous Endocrine: Evidence of thyroid hypofunction

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HMMRA2 17,109,1985
oral
rat
lowest published toxic dose: 4.62 gm/kg/5 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides
NEROEW 25,729,2001
oral
rat
lowest published toxic dose: 72,000 mg/kg/90 day- intermittent Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
REPTED 17,683,2003
oral
rat
lowest published toxic dose: 72,000 mg/kg/90 day- intermittent Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight
REPTED 17,683,2003
oral
rat
lowest published toxic dose: 99,000 mg/kg/90 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
REPTED 17,683,2003
oral
rat
lowest published toxic dose: 840 mg/kg/7 day- continuous Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS EJPHAZ 489,187,2004
oral
rat
lowest published toxic dose: 648 mg/kg/9 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase

Biochemical: Metabolism (intermediary): Other proteins
NEROEW 29,32,2004
oral
rat
lowest published toxic dose: 42 gm/kg/3 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JPETAB 305,434,2003
oral
rat
lowest published toxic dose: 4.29 gm/kg/14 day- continuous Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 1.62 gm/kg/7 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 4.2 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 1.72 gm/kg/7 day- continuous Endocrine: Evidence of thyroid hypofunction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 2.12 gm/kg/7 day- continuous Endocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 4.43 gm/kg/21 day- continuous Endocrine: Evidence of thyroid hypofunction

Endocrine: Androgenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 4.04 gm/kg/14 day- continuous Endocrine: Estrogenic

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 3.9 gm/kg/21 day- continuous Endocrine: Estrogenic

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 5.95 gm/kg/28 day- continuous Endocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 4.54 gm/kg/14 day- continuous Endocrine: Androgenic

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 1.52 gm/kg/7 day- continuous Reproductive: Maternal effects: Menstrual cycle changes or disorders

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HETOEA 25,243,2006
oral
rat
lowest published toxic dose: 173.6 mg/kg/8 week- continuous Kidney, Ureter, and Bladder: Other changes

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
PHREP* 59,291,2007
oral
rat
lowest published toxic dose: 33.6 mg/kg/8 week- continuous Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals
PHREP* 59,291,2007
oral
woman
lowest published toxic dose: 60 mg/kg/2 day- intermittent Brain and Coverings: Changes in surface EEG

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
AJEMEN 20,570,2002
unreported route
rat
lowest published toxic dose: 300 mg/kg/3 day- intermittent Kidney, Ureter, and Bladder: Urine volume increased

Blood: Other changes
FATOAO 47,15,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
DICPBB 8,690,1974
TOXICOLOGY REVIEW
EURNE* 12,361,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84414;
Number of Industries 8;
Total Number of Facilities 1,035;
Number of Occupations 10;
Total Number of Employees Exposed 6,333
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6906;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 198;
Total Number of Female Employees Exposed 151
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84414;
Number of Industries 17;
Total Number of Facilities 2,182;
Number of Occupations 31;
Total Number of Employees Exposed 39,147;
Total Number of Female Employees Exposed 17,568


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
56ZJAL "Metal Ions in Biology and Medicine, Proceedings of the International Symposium, 1st, 1990," Collery, P., and Manfait, M., et al., eds., Paris, France, 1990.
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Used in treatment of manic-depressive psychoses

NIOSH PROFILE (LITHIUM AND ITS COMPOUNDS), SRC, 4/78

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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