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Registry of Toxic Effects of Chemical Substances (RTECS)

Lithium

RTECS #

OJ5540000

CAS #

7439-93-2

Updated

October 2011

Molecular Weight

6.94

Molecular Formula

Li

Synonyms

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisunreported route/human714 mg/kg/8W- intermittentLANCAO 2,435,1969

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
unreported route/woman 3.927 gm/kg (18-34W pregnant)Reproductive: Effects on newborn: Biochemical and metabolicIJOBA* 17,164,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 1000 mg/kgUSXXAM #6441582

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2100 mg/kg/4W- continuousBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Vascular: Structural changes in vessels
TOLED5 180S,S40,2008
unreported route/woman lowest published toxic dose: 3.927 gm/kg/17W- intermittentBehavioral: Excitement

Reproductive: Effects on newborn: Biochemical and metabolic
IJOBA* 17,164,2008

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWARPTDI 16,231,1976
TOXICOLOGY REVIEWKDYIA5 10,82,1976
TOXICOLOGY REVIEWQJMEA7 47,123,1978
TOXICOLOGY REVIEWCNMEAH 54,115,1990
TOXICOLOGY REVIEWJTCTDW 39,4,2001
TOXICOLOGY REVIEWCTOXAO 39,381,2001
TOXICOLOGY REVIEWTPHSDY 24,441,2003
TOXICOLOGY REVIEWJOPSEQ 20,17,2006
TOXICOLOGY REVIEWJOPSEQ 20,23,2006
TOXICOLOGY REVIEWJOPSEQ 19,16,2005
TOXICOLOGY REVIEWJOPSEQ 20,31,2006
TOXICOLOGY REVIEWJOPSEQ 20,347,2006
TOXICOLOGY REVIEWTOPADD 32(Suppl. 2),71,2004
TOXICOLOGY REVIEWAJEMEN 22,404,2004
TOXICOLOGY REVIEWPAREAQ 56,103,2004
TOXICOLOGY REVIEWPSBUL* 36,91,2002
TOXICOLOGY REVIEWMJAUAJ 187,361,2007
TOXICOLOGY REVIEWPSBUL* 40,134,2007
TOXICOLOGY REVIEWCOCPH* -,701,2008
TOXICOLOGY REVIEWCCACL* 24,635,2008
TOXICOLOGY REVIEWDERCL* 25,215,2007
TOXICOLOGY REVIEWDERCL* 25,233,2007
TOXICOLOGY REVIEWNCLNA* 16,141,1998
TOXICOLOGY REVIEWNEUCL* 18,215,2000
TOXICOLOGY REVIEWNCLNA* 16,107,1998
TOXICOLOGY REVIEWNEUCL* 23,397,2005
TOXICOLOGY REVIEWMEDIAV 37,263,2009
TOXICOLOGY REVIEWTXAPA9 243,167,2010
TOXICOLOGY REVIEWNTAPM* -,617,1995
TOXICOLOGY REVIEWFCLPH* 22(Suppl 1),52,2008
TOXICOLOGY REVIEWFCLPH* 21(Suppl 1),68,2007
TOXICOLOGY REVIEWNBREV* 31,932,2007
TOXICOLOGY REVIEWMUREAV 723,77,2011
TOXICOLOGY REVIEWREPTED 31,255,2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80295; Number of Industries 8; Total Number of Facilities 207; Number of Occupations 11; Total Number of Employees Exposed 3455; Total Number of Female Employees Exposed 1084
National Occupational Hazard Survey 1974Hazard Code 80295; Number of Industries 8; Total Number of Facilities 372; Number of Occupations 11; Total Number of Employees Exposed 1942

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
OSHA ANALYTICAL METHOD #ID121
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