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Registry of Toxic Effects of Chemical Substances (RTECS)

Lead(II) nitrate (1:2)

RTECS #

OG2100000

CAS #

10099-74-8; 18256-98-9

Updated

September 201

Molecular Weight

331.21

Molecular Formula

N2O6·Pb

Synonyms

Lead dinitrate
Lead nitrate
Lead(2+) nitrate
Lead(II) nitrate
Nitrate de plomb (French)
Nitric acid, lead(2+) salt
Plumbous nitrate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/rat300 µmol/LCBINA8 30,237,1980
Cytogenetic Analysisparenteral/mouse200 µg/kgMILEDM 17,29,1981
Cytogenetic Analysisintravenous/mouse12500 µg/kgACAEAS 135,185,1989
Cytogenetic Analysisintraperitoneal/mouse10 mg/kgMUREAV 241,305,1990
Cytogenetic Analysislymphocyte/human1.2 mmol/L/2HDCTODJ 1,111,2006
DNA Damagelymphocyte/human2.4 mmol/L/2HDCTODJ 1,111,2006
DNA Damageother cell types/human10 µmol/L/24HTOLED5 173,201,2007
DNA Damageoral/Drosophila melanogaster2 mmol/LMUREAV 724,35,2011
DNA Damagelung/hamster1700 µmol/LMUREAV 298,97,1992
DNA DamageAscites tumor/rat5 mmol/LJBCHA3 261,3370,1986
DNA Damageoral/mouse0.7 mg/kgTXCYAC 145,201,2000
DNA inhibitionliver/rat100 µmol/LJTEHD6 4,503,1978
micronucleus testintraperitoneal/mouse625 µg/kgMUREAV 415,131,1998
micronucleus testlymphocyte/human10 mg/LTXAPA9 197,259,2004
mutation in mammalian somatic cellslymphocyte/mouse450 mg/LJTEHD6 9,367,1982
phage inhibition capacity/Escherichia coli320 µmol/LENMUDM 6,59,1984
sister chromatid exchangeovary/hamster3 µmol/LEMMUEG 23,143,1994
sister chromatid exchangeintravenous/mouse150 mg/kgEXPADD 36,65,1989
sister chromatid exchangeintraperitoneal/mouse10 mg/kgEMMUEG 21,229,1993

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 50 mg/kg (3D pregnant)Reproductive: Effects on fertility: Other measures of fertilityBECTA6 25,702,1980
intratesticular/rat 6624 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964
intravenous/mouse 100 mg/kg (9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
EXPADD 36,65,1989
intravenous/hamster 25 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ANREAK 157,358,1967
intravenous/hamster 50 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Central nervous system
ENVRAL 17,325,1978
intravenous/hamster 50 mg/kg (8D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
LAINAW 37,369,1977
intravenous/hamster 50 mg/kg (8D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
LAINAW 37,369,1977
intravenous/rat 25 mg/kg (15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathJTEHD6 9,1007,1982
intravenous/rat 7993 µg/kg (17D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)BNEOBV 41,193,1982
intravenous/rat 25 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 9,1021,1982
intravenous/rat 39964 µg/kg (17D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Behavioral
BNEOBV 41,193,1982
intravenous/rat 25 mg/kg (15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)NTIS** CONF-771017
intravenous/rat 25 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTXAPA9 31,72,1975
oral/rat 13 gm/kg (6W male/6W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)JLCMAK 87,273,1976
oral/rat 27 gm/kg (6W male/6W pre-3W after birth)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)JLCMAK 87,273,1976
oral/rat 43 mg/kg (1-22D preg/21D after birth)Reproductive: Effects on newborn: BehavioralNTOTDY 7,499,1985
oral/rat 36 mg/kg (10D male/10D pre-16D pregnant)Reproductive: Specific developmental abnormalities: Central nervous systemNETEEC 10,453,1988
oral/rat 38 mg/kg (22W prior to copulation)Reproductive: Specific developmental abnormalities: Central nervous systemBEBMAE 128,667,1999
oral/rat 200 mg/kg (18D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
BEBMAE 129(1),28,2000
subcutaneous/mouse 25 mg/kg (10D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
AECTCV 42,93,2002
subcutaneous/mouse 6624 µg/kg (30D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/jqbInhibitor Concentration Low: 1 µmol/L/1HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXCYAC 279,45,2011
In Vitro/Non-mammalian species, fibroblast Inhibitor Concentration (50 percent kill): 3.17 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,537,1993
intraperitoneal/mouse lethal dose (50 percent kill): 74 mg/kgBECTA6 9,80,1973
intraperitoneal/rat lowest published lethal dose: 270 mg/kgEQSSDX 1,1,1975
intravenous/rat lethal dose (50 percent kill): 93 mg/kgPSEBAA 92,331,1956
intravenous/rat lowest published toxic dose: 5 mg/kgGastrointestinal: Ulceration or bleeding from small intestine

Blood: Changes in cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
JJTHEC 9,1007,1982
intravenous/rat lowest published toxic dose: 25 mg/kgKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJTHEC 9,1007,1982
intravenous/rat lowest published toxic dose: 33.1 mg/kgLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 76,398,2002
intravenous/rat lowest published toxic dose: 33121 µg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JJATDK 26,381,2006
intravenous/rat lowest published toxic dose: 66242 µg/kgLiver: Other changes

Liver: Changes in liver weight
TOPADD 37,209,2009
oral/guinea pig lowest published lethal dose: 500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Body temperature decrease
AHBAAM 125,273,1941
oral/woman lowest published toxic dose: 360 mg/kgGastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Other
TIHEEC 25,137,2009
Tank with water/other fish lethal concentration (50 percent kill): >4.5 mg/L/24HAQUTO* 7,135,1985
Tank with water/other fish lethal concentration (50 percent kill): >4.5 mg/L/48HAQUTO* 7,135,1985
Tank with water/other fish lethal concentration (50 percent kill): >4.5 mg/L/72HAQUTO* 7,135,1985
Tank with water/other fish lethal concentration (50 percent kill): >4.5 mg/L/96HAQUTO* 7,135,1985
unreported route/rat lethal dose (50 percent kill): 3613 mg/kgGISAAA 50(3),57,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
multiple/non-mammalian species lowest published toxic dose: 15.5 ppm/60D- continuousVascular: Effect on gills and gill functionsFCTOD7 46,2440,2008
oral/duck lowest published toxic dose: 43 mg/kg/12W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesJTEHD6 1,929,1976
oral/guinea pig lowest published toxic dose: 1350 mg/kg/30D- intermittentBlood: Other changes

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
TPKVAL 2,148,1961
oral/mouse lowest published toxic dose: 97 mg/kg/27D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesARTODN 45,197,1980
oral/mouse lowest published toxic dose: 2000 mg/kg/40D- intermittentBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 48,928,2010
oral/rat lowest published toxic dose: 5.6 mg/kg/60D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonalETOPFR 19,113,2005
oral/rat lowest published toxic dose: 17.6 mg/kg/60D- intermittentBrain and Coverings: Other degenerative changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
ETOPFR 19,113,2005
oral/rat lowest published toxic dose: 1200 mg/kg/60D- intermittentBlood: Other changesKHZDAN 11,157,1968
subcutaneous/mouse lowest published toxic dose: 56 mg/kg/7D- intermittentEndocrine: Effect on menstrual cycleABICR* 15,121,1972
subcutaneous/rat lowest published toxic dose: 140 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition
ETOPFR 17,159,2004
subcutaneous/rat lowest published toxic dose: 7 gm/kg/7D- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GTPZAB 16(5),54,1972

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg(Pb)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,325,1980
TOXICOLOGY REVIEW85DHAX Pb,254,1972
TOXICOLOGY REVIEWMUREAV 613,17,2006
TOXICOLOGY REVIEWMUREAV 533,133,2003
TOXICOLOGY REVIEWMUREAV 533,227,2003
TOXICOLOGY REVIEWMUREAV 681,3,2009
TOXICOLOGY REVIEWIMEMDT 87,225,
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg(Pb)/m3 (fume, dust), MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg(Pb)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg(Pb)/m3, short term exposure limit 0.2 mg(Pb)/m3 (resp), SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 0.15 mg(Pb)/m3, short term exposure limit 0.6 mg(Pb)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Pb)/m3, 2B carc, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.15 mg(Pb)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Pb)/m3 (dust and fume), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Pb)/m3 (total dust);time-weighted average 0.5 mg(Pb)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Pb)/m3, KZG-week 0.8 mg(Pb)/m3, carc 3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Pb)/m3, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air10H time-weighted average <0.1 mg(Pb)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84473; Number of Industries 18; Total Number of Facilities 450; Number of Occupations 20; Total Number of Employees Exposed 11440; Total Number of Female Employees Exposed 4246
National Occupational Hazard Survey 1974Hazard Code 84473; Number of Industries 4; Total Number of Facilities 112; Number of Occupations 5; Total Number of Employees Exposed 420

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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