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Lead (II) nitrate (1:2)

RTECS #: OG2100000

CAS #: 10099-74-8


UPDATE: May 2009 MW: 331.21 MF: N2O6Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Lead dinitrate
  2. Lead nitrate
  3. Lead (2+) nitrate
  4. Lead (II) nitrate
  1. Nitrate de plomb (French)
  2. Nitric acid, lead (2+) salt
  3. Plumbous nitrate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 1.2 mmol/L/2 hour DCTODJ 1,111,2006
cytogenetic analysis parenteral
mouse
200 g/kg MILEDM 17,29,1981
cytogenetic analysis intravenous
mouse
12,500 g/kg ACAEAS 135,185,1989
cytogenetic analysis intraperitoneal
mouse
10 mg/kg MUREAV 241,305,1990
cytogenetic analysis rat other cell types 300 mol/L CBINA8 30,237,1980
DNA damage hamster lung 1,700 mol/L MUREAV 298,97,1992
DNA damage human lymphocyte 2.4 mmol/L/2 hour DCTODJ 1,111,2006
DNA damage human other cell types 10 mol/L/24 hour TOLED5 173,201,2007
DNA damage oral
mouse
0.7 mg/kg TXCYAC 145,201,2000
DNA damage rat Ascites tumor 5 mmol/L JBCHA3 261,3370,1986
DNA inhibition rat liver 100 mol/L JTEHD6 4,503,1978
micronucleus test human lymphocyte 10 mg/L TXAPA9 197,259,2004
micronucleus test intraperitoneal
mouse
625 g/kg MUREAV 415,131,1998
mutation in mammalian somatic cells mouse lymphocyte 450 mg/L JTEHD6 9,367,1982
phage inhibition capacity Escherichia coli 320 mol/L ENMUDM 6,59,1984
sister chromatid exchange hamster ovary 3 mol/L EMMUEG 23,143,1994
sister chromatid exchange intravenous
mouse
150 mg/kg EXPADD 36,65,1989
sister chromatid exchange intraperitoneal
mouse
10 mg/kg EMMUEG 21,229,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg (3 day pregnant) Reproductive: Effects on fertility: Other measures of fertility BECTA6 25,702,1980
intratesticular
rat
lowest published toxic dose: 6,624 g/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
intravenous
hamster
lowest published toxic dose: 25 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ANREAK 157,358,1967
intravenous
hamster
lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Central nervous system
ENVRAL 17,325,1978
intravenous
hamster
lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
LAINAW 37,369,1977
intravenous
hamster
lowest published toxic dose: 50 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Homeostasis

Reproductive: Other developmental abnormalities
LAINAW 37,369,1977
intravenous
mouse
lowest published toxic dose: 100 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
EXPADD 36,65,1989
intravenous
rat
lowest published toxic dose: 7,993 g/kg (17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) BNEOBV 41,193,1982
intravenous
rat
lowest published toxic dose: 25 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 9,1021,1982
intravenous
rat
lowest published toxic dose: 39,964 g/kg (17 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Behavioral
BNEOBV 41,193,1982
intravenous
rat
lowest published toxic dose: 25 mg/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** CONF-771017
intravenous
rat
lowest published toxic dose: 25 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TXAPA9 31,72,1975
intravenous
rat
lowest published toxic dose: 25 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JTEHD6 9,1007,1982
oral
rat
lowest published toxic dose: 13 gm/kg (6 week male/6 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JLCMAK 87,273,1976
oral
rat
lowest published toxic dose: 27 gm/kg (6 week male/6 week prior to copulation-3 week after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) JLCMAK 87,273,1976
oral
rat
lowest published toxic dose: 43 mg/kg (1-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Behavioral NTOTDY 7,499,1985
oral
rat
lowest published toxic dose: 36 mg/kg (10 day male/10 day prior to copulation-16 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system NETEEC 10,453,1988
oral
rat
lowest published toxic dose: 38 mg/kg (22 week prior to copulation) Reproductive: Specific developmental abnormalities: Central nervous system BEBMAE 128,667,1999
oral
rat
lowest published toxic dose: 200 mg/kg (18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
BEBMAE 129(1),28,2000
subcutaneous
mouse
lowest published toxic dose: 6,624 g/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 7,21,1964
subcutaneous
mouse
lowest published toxic dose: 25 mg/kg (10 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
AECTCV 42,93,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 74 mg/kg N/R BECTA6 9,80,1973
intraperitoneal
rat
lowest published lethal dose: 270 mg/kg N/R EQSSDX 1,1,1975
intravenous
rat
lethal dose (50 percent kill): 93 mg/kg N/R PSEBAA 92,331,1956
intravenous
rat
lowest published toxic dose: 5 mg/kg Gastrointestinal: Ulceration or bleeding from small intestine

Blood: Changes in cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
JJTHEC 9,1007,1982
intravenous
rat
lowest published toxic dose: 25 mg/kg Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJTHEC 9,1007,1982
intravenous
rat
lowest published toxic dose: 33.1 mg/kg Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Lipids including transport
ARTODN 76,398,2002
intravenous
rat
lowest published toxic dose: 33,121 g/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
JJATDK 26,381,2006
oral
guinea pig
lowest published lethal dose: 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Body temperature decrease
AHBAAM 125,273,1941
unreported route
rat
lethal dose (50 percent kill): 3,613 mg/kg N/R GISAAA 50(3),57,1985


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
duck
lowest published toxic dose: 43 mg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes JTEHD6 1,929,1976
oral
guinea pig
lowest published toxic dose: 1,350 mg/kg/30 day- intermittent Blood: Other changes

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
TPKVAL 2,148,1961
oral
mouse
lowest published toxic dose: 97 mg/kg/27 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes ARTODN 45,197,1980
oral
rat
lowest published toxic dose: 1,200 mg/kg/60 day- intermittent Blood: Other changes KHZDAN 11,157,1968
oral
rat
lowest published toxic dose: 5.6 mg/kg/60 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal ETOPFR 19,113,2005
oral
rat
lowest published toxic dose: 17.6 mg/kg/60 day- intermittent Brain and Coverings: Other degenerative changes

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
ETOPFR 19,113,2005
subcutaneous
mouse
lowest published toxic dose: 56 mg/kg/7 day- intermittent Endocrine: Effect on menstrual cycle ABICR* 15,121,1972
subcutaneous
rat
lowest published toxic dose: 7 gm/kg/7 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GTPZAB 16(5),54,1972
subcutaneous
rat
lowest published toxic dose: 140 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition
ETOPFR 17,159,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(Pb)/m3 DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,325,1980
TOXICOLOGY REVIEW
85DHAX Pb,254,1972
TOXICOLOGY REVIEW
MUREAV 613,17,2006
TOXICOLOGY REVIEW
MUREAV 533,133,2003
TOXICOLOGY REVIEW
MUREAV 533,227,2003
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.15 mg(Pb)/m3 (dust, fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(Pb)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.15 mg(Pb)/m3, APR 2004
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Pb)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.05 mg(Pb)/m3, short term exposure limit 0.2 mg(Pb)/m3 (resp), SEP2000
Occupational Exposure Limit - HUNGARY time-weighted average 0.15 mg(Pb)/m3, short term exposure limit 0.6 mg(Pb)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Pb)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.15 mg(Pb)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Pb)/m3 (dust and fume), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Pb)/m3 (total dust);
time-weighted average 0.5 mg(Pb)/m3 (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Pb)/m3;
KZG- week 0.8 mg(Pb)/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 mg(Pb)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg(Pb)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air 10 hour time-weighted average <0.1 mg(Pb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84473;
Number of Industries 4;
Total Number of Facilities 112;
Number of Occupations 5;
Total Number of Employees Exposed 420
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84473;
Number of Industries 18;
Total Number of Facilities 450;
Number of Occupations 20;
Total Number of Employees Exposed 11,440;
Total Number of Female Employees Exposed 4,246


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a mordant, a chemical reagent, and in production of matches, and pyrotechnics
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ABICR* Acta Biologica Cracoviensia. ("Vesalius" University Medical Publisher: ul. Wislisko 1, 31-538 Cracow, Poland) V.38- 1996-
ACAEAS Acta Anaesthesiologica. (Padua, Italy) V.1-22, 1950-71. For publisher information, see AANIBO.
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EXPADD Experimental Pathology (1981). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.19- 1981-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JBCHA3 Journal of Biological Chemistry. (428 E. Preston St., Baltimore, MD 21202) V.1- 1905-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1952-
MILEDM Microbios Letters. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a mordant, a chemical reagent, and in production of matches, and pyrotechnics

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 18256-98-9
Click Here for Additional Information about RTECS

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