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Registry of Toxic Effects of Chemical Substances (RTECS)

Lead monoxide

RTECS #

OG1750000

CAS #

1317-36-8

Updated

September 201

Molecular Weight

223.19

Molecular Formula

OPb

Synonyms

C.I. 77577
C.I. Pigment Yellow 46
Lead monooxide
Lead oxide
Lead Oxide Yellow
Lead protoxide
Lead(II) oxide
Litharge
Litharge Pure
Litharge Yellow L-28
Plumbous oxide
Yellow Lead Ocher

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 100 mg/24H mildAEHLAU 30,168,1975

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/hamster50 µmol/LCNREA8 39,193,1979

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 1750 mg/kg (5W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOLED5 115,1,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 217 mg/kgVCVN1* -,426,1988
intraperitoneal/rat lowest published lethal dose: 430 mg/kgBlood: Other changesINMEAF 10,15,1941
oral/Dog lowest published lethal dose: 1400 mg/kgHBAMAK 4,1289,1935

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10 µg/m3/24H/22W- continuousBrain and Coverings: Recordings from specific areas of CNS

Blood: Changes in bone marrow not included in above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 43(6),96,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg(Pb)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,325,1980
TOXICOLOGY REVIEW85DHAX Pb,254,1972
TOXICOLOGY REVIEWIMEMDT 87,225,

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg(Pb)/m3 (fume, dust), MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg(Pb)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg(Pb)/m3, short term exposure limit 0.2 mg(Pb)/m3 (resp), SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 0.15 mg(Pb)/m3, short term exposure limit 0.6 mg(Pb)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Pb)/m3, 2B carc, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.15 mg(Pb)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Pb)/m3 (dust and fume), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Pb)/m3 (total dust);time-weighted average 0.5 mg(Pb)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Pb)/m3, KZG-week 0.8 mg(Pb)/m3, carc 3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Pb)/m3, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air10H time-weighted average <0.1 mg(Pb)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0125; Number of Industries 40; Total Number of Facilities 2531; Number of Occupations 47; Total Number of Employees Exposed 59832; Total Number of Female Employees Exposed 19722
National Occupational Hazard Survey 1974Hazard Code M0125; Number of Industries 35; Total Number of Facilities 1613; Number of Occupations 37; Total Number of Employees Exposed 23488

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NIOSH Analytical Method, 1994: Lead, by flame AAS, 7082; or by HGAAS, 7105
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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