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Lead carbonate

RTECS #: OF9275000

CAS #: 598-63-0


UPDATE: May 2009 MW: 267.20 MF: CO3•Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Carbonic acid, lead (2+) salt (1:1)
  2. Cerussete
  3. Dibasic lead carbonate
  1. Lead (2+) carbonate
  2. Plumbous carbonate
  3. White lead


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 40 gm/kg (16 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
TXAPA9 37,160,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
guinea pig
lowest published lethal dose: 1 gm/kg N/R EQSSDX 1,1,1975
oral
human
lowest published lethal dose: 571 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
IPSTB3 3,93,1976
oral
man
lowest published toxic dose: 214 mg/kg/4 week Gastrointestinal: Contraction (isolated tissue)

Liver: Jaundice, other or unclassified
NEJMAG 303,459,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 4,500 mg/kg/90 day- continuous Behavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,160,1976
oral
guinea pig
lowest published toxic dose: 1,860 mg/kg/6 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Irritability

Nutritional and Gross Metabolic: Changes in: Other metals
ANPTAL 33,185,1975
oral
mammal (species unspecified)
lowest published toxic dose: 1,200 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 8,33,1966
oral
mammal (species unspecified)
lowest published toxic dose: 0.12 mg/kg/10 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
TPKVAL 8,33,1966
oral
mouse
lowest published toxic dose: 57,600 mg/kg/12 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BECTA6 9,80,1973
oral
rat
lowest published toxic dose: 27,500 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
PHRPA6 56,1610,1941
oral
rat
lowest published toxic dose: 18,000 mg/kg/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease
JTPAE7 29,451,2001
oral
rat
lowest published toxic dose: 32,000 mg/kg/16 day- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 29,451,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg(Pb)/m3 DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 1,40,1972
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 23,325,1980
TOXICOLOGY REVIEW
85DHAX Pb,258,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.15 mg(Pb)/m3 (dust, fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg(Pb)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.15 mg(Pb)/m3, APR 2004
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg(Pb)/m3, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.05 mg(Pb)/m3, short term exposure limit 0.2 mg(Pb)/m3 (resp), SEP2000
Occupational Exposure Limit - HUNGARY time-weighted average 0.15 mg(Pb)/m3, short term exposure limit 0.6 mg(Pb)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg(Pb)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - MEXICO time-weighted average 0.15 mg(Pb)/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Pb)/m3 (dust and fume), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Pb)/m3 (total dust);
time-weighted average 0.5 mg(Pb)/m3 (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Pb)/m3;
KZG- week 0.8 mg(Pb)/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg(Pb)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air 10 hour time-weighted average <0.1 mg(Pb)/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80252;
Number of Industries 78;
Total Number of Facilities 2,919;
Number of Occupations 55;
Total Number of Employees Exposed 48,818
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80252;
Number of Industries 8;
Total Number of Facilities 139;
Number of Occupations 12;
Total Number of Employees Exposed 2,791;
Total Number of Female Employees Exposed 772


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a pigment in paints, ceramic glazes, putty and cements
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ANPTAL Acta Neuropathologica. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1961-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a pigment in paints, ceramic glazes, putty and cements

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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