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Registry of Toxic Effects of Chemical Substances (RTECS)

Lead carbonate

RTECS #

OF9275000

CAS #

598-63-0

Updated

September 201

Molecular Weight

267.20

Molecular Formula

CO3·Pb

Synonyms

Carbonic acid, lead(2+) salt (1:1)
Cerussete
Dibasic lead carbonate
Lead(2+) carbonate
Plumbous carbonate
White lead

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 40 gm/kg (16D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
TXAPA9 37,160,1976

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lowest published lethal dose: 1 gm/kgEQSSDX 1,1,1975
oral/human lowest published lethal dose: 571 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
IPSTB3 3,93,1976
oral/man lowest published toxic dose: 214 mg/kg/4WGastrointestinal: Contraction (isolated tissue)

Liver: Jaundice, other or unclassified
NEJMAG 303,459,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 4500 mg/kg/90D- continuousBehavioral: Ataxia

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 37,160,1976
oral/guinea pig lowest published toxic dose: 1860 mg/kg/6D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Irritability

Nutritional and Gross Metabolic: Changes in: Other metals
ANPTAL 33,185,1975
oral/mammal (species unspecified) lowest published toxic dose: 1200 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 8,33,1966
oral/mammal (species unspecified) lowest published toxic dose: 0.012 mg/kg/10D- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
TPKVAL 8,33,1966
oral/mouse lowest published toxic dose: 57600 mg/kg/12D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BECTA6 9,80,1973
oral/rat lowest published toxic dose: 27500 mg/kg/2Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
PHRPA6 56,1610,1941
oral/rat lowest published toxic dose: 18000 mg/kg/9D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Body temperature decrease
JTPAE7 29,451,2001
oral/rat lowest published toxic dose: 32000 mg/kg/16D- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 29,451,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 mg(Pb)/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 1,40,1972
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 23,325,1980
TOXICOLOGY REVIEW85DHAX Pb,258,1972

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 mg(Pb)/m3 (fume, dust), MAY2011
Occupational Exposure Limit-FRANCEVME 0.1 mg(Pb)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.05 mg(Pb)/m3, short term exposure limit 0.2 mg(Pb)/m3 (resp), SEP2000
Occupational Exposure Limit-HUNGARYtime-weighted average 0.15 mg(Pb)/m3, short term exposure limit 0.6 mg(Pb)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Pb)/m3, 2B carc, MAY2012
Occupational Exposure Limit-MEXICOtime-weighted average 0.15 mg(Pb)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Pb)/m3 (dust and fume), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.05 mg(Pb)/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.05 mg(Pb)/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Pb)/m3 (total dust);time-weighted average 0.5 mg(Pb)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(Pb)/m3, KZG-week 0.8 mg(Pb)/m3, carc 3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.2 mg(Pb)/m3, JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO LEAD, INORGANIC-air10H time-weighted average <0.1 mg(Pb)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80252; Number of Industries 8; Total Number of Facilities 139; Number of Occupations 12; Total Number of Employees Exposed 2791; Total Number of Female Employees Exposed 772
National Occupational Hazard Survey 1974Hazard Code 80252; Number of Industries 78; Total Number of Facilities 2919; Number of Occupations 55; Total Number of Employees Exposed 48818

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
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