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Registry of Toxic Effects of Chemical Substances (RTECS)

Lead, bis(dimethyldithiocarbamato)-

RTECS #

OF8850000

CAS #

19010-66-3

Updated

December 2012

Molecular Weight

447.63

Molecular Formula

C6H12N2S4·Pb

Synonyms

Bis(dimethylcarbamodithioato-S,S')lead
Bis(dimethyldithiocarbamato)lead
Carbamic acid, dimethyldithio-, lead salt
Lead dimethyldithiocarbamate
Lead, bis(dimethylcarbamodithioato-S,S')-, (T-4)- (9CI)
Methyl ledate
NCI-C02891

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms/Salmonella typhimurium33 µg/plate (-enzymatic activation step)NTPTB* JAN1982

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 12,131,1976
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,230,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,230,1987
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Pb)/m3, 2B carc, MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83298; Number of Industries 1; Total Number of Facilities 16; Number of Occupations 3; Total Number of Employees Exposed 4428; Total Number of Female Employees Exposed 80
National Occupational Hazard Survey 1974Hazard Code 83298; Number of Industries 1; Total Number of Facilities 27; Number of Occupations 14; Total Number of Employees Exposed 1346

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-151,1979
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