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Lead, bis (dimethyldithiocarbamato) -

RTECS #: OF8850000

CAS #: 19010-66-3


UPDATE: February 2009 MW: 447.63 MF: C6H12N2S4Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Bis (dimethylcarbamodithioato - S,S') lead
  2. Bis (dimethyldithiocarbamato) lead
  3. Carbamic acid, dimethyldithio - , lead salt
  4. Lead dimethyldithiocarbamate
  1. Lead, bis (dimethylcarbamodithioato - S,S') - , (T - 4) - (9CI)
  2. Methyl ledate
  3. NCI - C02891


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 33 g/plate (-enzymatic activation step) NTPTB* JAN1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 1,000 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 12,131,1976
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,230,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,230,1987
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 0.15 mg(Pb)/m3 (dust, fume), MAR2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83298;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 14;
Total Number of Employees Exposed 1,346
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83298;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 3;
Total Number of Employees Exposed 4,428;
Total Number of Female Employees Exposed 80


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an accelerator in the rubber-processing industry
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-151,1979


REFERENCES:

CODEN
REFERENCE

ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTB* NTP Technical Bulletin. (National Toxicology Program, Landow Bldg. 3A-06, 7910 Woodmont Ave., Bethesda, MD 20205)

Used as an accelerator in the rubber-processing industry

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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