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Lauroyl peroxide

RTECS #: OF2625000

CAS #: 105-74-8


UPDATE: November 2003 MW: 398.70 MF: C24H46O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Alperox C
  2. Dilauroyl peroxide
  3. Dilauryl peroxide
  4. Dodecanoyl peroxide
  5. Dyp - 97F
  6. LYP 97
  1. LYP 97F
  2. Laurox
  3. Laurydol
  4. Peroxide, bis (1 - oxododecyl) -
  5. Peroxyde de lauroyle (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,324,1986
skin
mouse
20 mg mild VCVGK* -,541,1994


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 184 mg/kg/46 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 37,825,1966
unreported route
mouse
lowest published toxic dose: 638 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease
RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lethal dose (50 percent kill): 10,000 mg/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,541,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 36,315,1985
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1485,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 36,315,1985
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1485,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1485,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83575;
Number of Industries 1;
Total Number of Facilities 28;
Number of Occupations 6;
Total Number of Employees Exposed 532
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83575;
Number of Industries 1;
Total Number of Facilities 60;
Number of Occupations 3;
Total Number of Employees Exposed 3,960


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Primary Irritant

Click Here for Additional Information about RTECS

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