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Isoprene

RTECS #: NT4037000

CAS #: 78-79-5


UPDATE: February 2008 MW: 68.13 MF: C5H8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,3 - Butadiene, 2 - methyl -
  2. 2 - Methylbutadiene
  3. 2 - Methyl - 1,3 - butadiene
  1. Isopentadiene
  2. NSC 9237
  3. beta - Methylbivinyl


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human leukocyte 5 mmol/L/2 hour (+enzymatic activation step) MUREAV 629,7,2007
DNA damage inhalation
mouse
700 ppm/26 week- intermittent CBINA8 135-136,373,2001
micronucleus test inhalation
mouse
438 ppm/6 hour/12 day- continuous MUTAEX 3,141,1988
sister chromatid exchange inhalation
mouse
438 ppm/6 hour/12 day- continuous MUTAEX 3,141,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 280 ppm (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #DE89008095/XAD
inhalation
mouse
lowest published toxic concentration: 7,000 ppm (6-17 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #DE89008095/XAD
inhalation
rat
lowest published toxic concentration: 7,000 ppm (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** #DE89008095/XAD


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 7,000 ppm/6 hour/26 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CNREA8 54,5333,1994
inhalation
mouse
lowest published toxic concentration: 700 ppm/6 hour/26 week - intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
CBINA8 135-136,373,2001
inhalation
rat
lowest published toxic concentration: 220 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
NTPTR* NTP-TR-486,1999
inhalation
rat
lowest published toxic concentration: 22,050 mg/kg/105 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Reproductive: Tumorigenic effects: Testicular tumors
NTIS** PB2000-101651
inhalation
rat
lowest published toxic concentration: 220,500 mg/kg/105 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTIS** PB2000-101651
inhalation
rat
lowest published toxic concentration: 5,775 mg/kg/105 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTIS** PB2000-101651


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 800 mg/m3 Gastrointestinal: Changes in structure or function of salivary glands VCVGH* -,65,1990
inhalation
cat
lowest published toxic concentration: 0.8 gm/m3/2 hour Skin: After systemic exposure: Dermatitis, other TPKVAL 6,18,1964
inhalation
cat
lowest published toxic concentration: 0.4 gm/m3/2 hour Eye: Conjunctiva irritation TPKVAL 6,18,1964
inhalation
human
lowest published toxic concentration: 160 mg/m3/1 minute Eye: Conjunctiva irritation VCVGH* -,66,1990
inhalation
mouse
lethal concentration (50 percent kill): 139 gm/m3/2 hour Lung, Thorax, or Respiration: Other changes GTPZAB 9(1),36,1965
inhalation
mouse
lethal concentration (50 percent kill): 130,000 mg/m3/2 hour N/R VCVGH* -,65,1990
inhalation
mouse
lethal concentration (16 percent kill): 117,000 mg/m3/2 hour N/R VCVGH* -,65,1990
inhalation
mouse
lethal concentration (84 percent kill): 212,000 mg/m3/2 hour N/R VCVGH* -,65,1990
inhalation
mouse
lowest published lethal concentration: 140 gm/m3 Behavioral: Alteration of classical conditioning TPKVAL 6,18,1964
inhalation
mouse
lethal concentration (50 percent kill): 150 gm/m3/2 hour Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 6,18,1964
inhalation
mouse
lowest published toxic concentration: 100 gm/m3/2 hour Skin: After systemic exposure: Dermatitis, other TPKVAL 6,18,1964
inhalation
rat
lethal concentration (50 percent kill): 180 gm/m3/4 hour Behavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory depression
RPTOAN 31,162,1968
inhalation
rat
lethal concentration (50 percent kill): 129,000 mg/m3/4 hour N/R VCVGH* -,65,1990
inhalation
rat
lethal concentration (16 percent kill): 92,000 mg/m3/4 hour N/R VCVGH* -,65,1990
inhalation
rat
lethal concentration (84 percent kill): 381,000 mg/m3/4 hour N/R VCVGH* -,65,1990
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/2 hour Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
TPKVAL 6,18,1964
inhalation
rabbit
lowest published toxic concentration: 750 mg/m3/40 minute Lung, Thorax, or Respiration: Dyspnea VCVGH* -,66,1990
inhalation
rabbit
lowest published toxic concentration: 300 mg/m3 Behavioral: Alteration of classical conditioning VCVGH* -,66,1990
oral
rat
lowest published lethal dose: 4.5 gm/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
VCVGH* -,66,1990
skin
mouse
lowest published toxic dose: 100 pph/3 hour Skin: After topical application: Corrosive TPKVAL 6,18,1964
skin
rabbit
lowest published toxic dose: 0.25 mL/kg Skin: After systemic exposure: Dermatitis, other VCVGH* -,67,1990
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 6,18,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 3,400 mg/m3/17 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in leukocyte (WBC) count
GTPZAB 9(1),36,1965
inhalation
mouse
lowest published toxic concentration: 3,400 mg/m3/17 week- intermittent Behavioral: Change in psychophysiological tests GTPZAB 9(1),36,1965
inhalation
mouse
lowest published toxic concentration: 700 ppm/6 hour/13 week- intermittent Gastrointestinal: Other changes CNREA8 54,5333,1994
inhalation
mouse
lowest published toxic concentration: 7,000 ppm/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #DE89008095/XAD
inhalation
mouse
lowest published toxic concentration: 1,400 ppm/14 day- intermittent Liver: Changes in liver weight NTIS** #DE89008095/XAD
inhalation
rat
lowest published toxic concentration: 3,400 mg/m3/22 week- intermittent Brain and Coverings: Changes in brain weight

Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in kidney weight
GTPZAB 9(1),36,1965
inhalation
rat
lowest published toxic concentration: 7,000 ppm/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #DE89008095/XAD
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3/61 day- intermittent Liver: Liver function tests impaired TPKVAL 6,18,1964
inhalation
rat
lowest published toxic concentration: 0.3 gm/m3/0.5 year- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 6,18,1964
intraperitoneal
mouse
lowest published toxic dose: 14,973.6 mg/kg/30 day- intermittent Reproductive: Maternal effects: Oogenesis CRTOEC 8,963,1995
oral
rat
lowest published toxic dose: 157 mg/kg/9 week- continuous Behavioral: Alteration of classical conditioning GISAAA 24(6),8,1959


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 60,215,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1015,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,215,1994
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1015,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1015,1999
TOXICOLOGY REVIEW
CBINA8 135-136,27,2001
TOXICOLOGY REVIEW
CBINA8 135-136,65,2001
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 40 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40940;
Number of Industries 36;
Total Number of Facilities 2,278;
Number of Occupations 43;
Total Number of Employees Exposed 58,102
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40940;
Number of Industries 6;
Total Number of Facilities 123;
Number of Occupations 15;
Total Number of Employees Exposed 3,703;
Total Number of Female Employees Exposed 578


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of cis-1,4-POLYISOPRENE RUBBER, STYRENE/ISOPRENE/STYRENE block polymers
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8707
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Toxicity studies, RPT# TOX-31, October 2000


REFERENCES:

CODEN
REFERENCE

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of cis-1,4-POLYISOPRENE RUBBER, STYRENE/ISOPRENE/STYRENE block polymers

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (ALKENES), SRC, 4/78

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

ALT CAS #: 78006-92-5
Click Here for Additional Information about RTECS

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