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Registry of Toxic Effects of Chemical Substances (RTECS)

Isopentyl alcohol, nitrite

RTECS #

NT0187500

CAS #

110-46-3

Updated

December 2010

Molecular Weight

117.17

Molecular Formula

C5H11NO2

Synonyms

3-Methylbutanol nitrite
3-Methylbutyl nitrite
Amyl nitrite
Aspiral
Isoamyl nitrite
Isopentyl nitrite
Nitramyl
Nitrous acid, 3-methylbutyl ester
Vaporole

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster160 mg/LEMMUEG 10(Suppl 10),1,1987
mutation in mammalian somatic cellslymphocyte/mouse3740 nmol/LEMMUEG 14,115,1989
mutation in microorganisms/Salmonella typhimurium333 µg/plate (+enzymatic activation step)ENMUDM 8(Suppl 7),1,1986
sister chromatid exchangeovary/hamster16 mg/LEMMUEG 10(Suppl 10),1,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1430 ppm/30MBehavioral: Change in motor activity (specific assay)NTOTDY 8,139,1986
inhalation/rat lethal concentration (50 percent kill): 716 ppm/4HBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis
FAATDF 8,101,1987
intraperitoneal/mouse lethal dose (50 percent kill): 130 mg/kgRCOCB8 5,889,1973
intravenous/Dog lowest published lethal dose: 167 mg/kgBehavioral: Convulsions or effect on seizure thresholdRCOCB8 5,889,1973
intravenous/mouse lethal dose (50 percent kill): 51 mg/kgRCOCB8 5,889,1973
oral/mouse lethal dose (50 percent kill): 852 mg/kgWDZAEK 5,119,1991
oral/rat lethal dose (50 percent kill): 505 mg/kgBehavioral: General anestheticFEPRA7 41,1583,1982
subcutaneous/cat lowest published lethal dose: 250 µL/kgYAKUD5 9,759,1967

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWARPTDI 43,97,2003
TOXICOLOGY REVIEWENTOX* -,110,2005
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWNCLNA* 16,503,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 83996; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 33

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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