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Registry of Toxic Effects of Chemical Substances (RTECS)

Isophthalic acid

RTECS #

NT2007000

CAS #

121-91-5

Updated

July 2013

Molecular Weight

166.14

Molecular Formula

C8H6O4

Synonyms

Acide isophtalique (French)
Benzene-1,3-dicarboxylic acid
Isophthalate
Kyselina isoftalova (Czech)
m-Benzenedicarboxylic acid
m-Phthalic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,317,1986
eye /rabbit 100 mg mildHPV211 -,-,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 1825000 mg/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV211 -,-,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >11370 mg/m3/4HHPV211 -,-,2006
intraperitoneal/mouse lethal dose (50 percent kill): 4200 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Nutritional and Gross Metabolic: Body temperature decrease
COREAF 246,851,1958
intraperitoneal/mouse lethal dose (50 percent kill): 4200 mg/kgHPV211 -,-,2006
intraperitoneal/rat lethal dose (50 percent kill): 13000 mg/kgHPV211 -,-,2006
oral/rat lethal dose (50 percent kill): >5 gm/kgHPV211 -,-,2006
oral/rat lethal dose (50 percent kill): 10900 mg/kgKidney, Ureter, and Bladder: Other changesHPV211 -,-,2006
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV211 -,-,2006

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 72800 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
HPV211 -,-,2006
oral/rat lowest published toxic dose: 365000 mg/kg/2Y- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV211 -,-,2006
oral/rat lowest published toxic dose: 1825000 mg/kg/2Y- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV211 -,-,2006

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWBPCT** -,183,1974
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 5 mg/m3, inhal, 2011
Occupational Exposure Limit-GERMANYMAK 5 mg/m3, inhal, 2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg/m3, KZG-week 4 mg/m3, inhal, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82897; Number of Industries 59; Total Number of Facilities 8709; Number of Occupations 49; Total Number of Employees Exposed 117411; Total Number of Female Employees Exposed 17858
National Occupational Hazard Survey 1974Hazard Code 82897; Number of Industries 67; Total Number of Facilities 3665; Number of Occupations 68; Total Number of Employees Exposed 55161

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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