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Registry of Toxic Effects of Chemical Substances (RTECS)

Isonicotinic acid hydrazide

RTECS #

NS1751850

CAS #

54-85-3; 7640-37-1; 37271-10-6; 41466-07-3; 62229-51-0

Updated

December 2013

Molecular Weight

137.16

Molecular Formula

C6H7N3O

Synonyms

4-(Hydrazinocarbonyl)pyridine
4-Pyridinecarboxylic acid, hydrazide
4-Pyridinecarboxylic hydrazide
5015 RP
Andrazide
Antimicina
Antituberkulosum
Armazide
Atcotibine
Azuren
BP 5015
Cedin
Cemidon
Chemiazid
Chemidon
Cotinazin
Defonin
Dibutin
Diforin
Dinacrin
Ditubin
Ebidene
Eralon
Ertuban
Eutizon
Evalon
Fimalene
FSR 3
GInk
HIA
Hidranizil
Hidrasonil
Hidrulta
Hidrun
Hycozid
Hydrazid
Hyozid
Hyzyd
I.A.I.
Ido-tebin
Idrazide dell'acido isonicotinico (Italian)
Idrazil
IN-73
INAH
INH
Inizid
Iscotin
Isidrina
Ismazide
Isobicina
Isocid
Isocidene
Isocotin
Isolyn
Isonerit
Isonex
Isoniazid
Isoniazide
Isonicazide
Isonicid
Isonico
Isonicotan
Isonicotil
Isonicotinhydrazid
Isonicotinoyl hydrazide
Isonicotinoylhydrazine
Isonicotinsaeurehydrazid (German)
Isonicotinyl hydrazide
Isonide
Isonidrin
Isonikazid
Isonilex
Isonin
Isonindon
Isonirit
Isoniton
Isonizide
Isotebe
Isotebezid
Isotinyl
Isozide
Isozyd
L 1945
Laniazid
Mybasan
Neoteben
Neo-tizide
Neoxin
Neumandin
Nevin
Niadrin
Nicazide
Nicetal
Nicizina
Niconyl
Nicotibina
Nicozide
Nidaton
Nidrazid
Nikozid
Niplen
Nitadon
Niteban
NSC 9659
Nydrazid
Pelazid
Phthisen
Preparation 6424
Pycazide
Pyrizidin
Raumanon
Razide
Retozide
Rifamate
Rimicid
Rimifon
Rimitsid
Robisellin
Roxifen
RU-EF-TB
Sanohidrazina
Sauterazid
Stanozide
TB-Phlogin
TB-Razide
TB-Vis
Tebecid
Tebenic
Tebexin
Tebilon
Tebos
Teebaconin
Tekazin
Tibazide
Tibinide
Tibison
Tibivis
Tibizide
Tibusan
Tisin
Tisiodrazida
Tizide
Tubazid
Tubazide
Tubeco
Tubercid
Tuberian
Tubicon
Tubomel
Tyvid
Unicozyde
USAF CB-2
Vazadrine
Vederon
Zinadon
Zonazide

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg/24H moderateTXAPA9 4,44,1962

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat90 mg/kgMUREAV 56,289,1978
Cytogenetic Analysisoral/rat900 mg/kg/12W- intermittentHUGEDQ 42,9,1978
Cytogenetic Analysisintravenous/rat65 mg/kgLANCAO 2,93,1971
Cytogenetic Analysislymphocyte/human7 mmol/LHUGEDQ 52,309,1979
Cytogenetic Analysisleukocyte/human5 gm/LEXPEAM 29,1433,1973
Cytogenetic Analysisbone marrow/human5 mg/LCRSBAW 169,1326,1975
Cytogenetic Analysisintraperitoneal/mouse14667 µg/kgNULSAK 22,96,1979
Cytogenetic AnalysisAscites tumor/mouse1 mmol/LPHARAT 32,178,1977
Cytogenetic Analysismammary gland/mouse3200 µmol/L/24H-continuousJTSCDR 5,141,1980
Cytogenetic Analysisintraperitoneal/mouse14700 µg/kgNULSAK 22,96,1979
Cytogenetic Analysisoral/hamster10 mg/kg/2W- intermittentHUGEDQ 42,9,1978
Cytogenetic Analysislung/hamster1 gm/LAMONDS 3,253,1980
Cytogenetic Analysisfibroblast/hamster3 gm/LESKHA5 (96),55,1978
DNA adductoral/mouse28 mg/kgHUTODJ 6,153,1987
DNA Damageintraperitoneal/mouse960 µmol/kgCNREA8 41,1469,1981
DNA Damageintraperitoneal/rat2100 mg/kg/21D- intermittentTXCYAC 264,185,2009
DNA inhibitionovary/hamster10 mmol/LMUREAV 50,251,1978
DNA inhibitionintraperitoneal/mouse90 mg/kgIJEBA6 19,939,1981
DNA inhibitionHeLa cell/human300 mmol/LJOUOD4 8(Suppl),291,1986
DNA inhibitionfibroblast/human10 mmol/LMUREAV 89,9,1981
DNA repair/Escherichia coli187 µg/wellMUREAV 133,161,1984
DNA repair/Other microorganisms7 mg/plateBIZNAT 95,463,1976
gene conversion and mitotic recombination/Saccharomyes cerevisiae25 mmol/LMUREAV 91,215,1981
host-mediated assaySalmonella typhimurium/rat150 mg/kgMUREAV 41,89,1976
host-mediated assaySalmonella typhimurium/mouse150 mg/kgMUREAV 41,89,1976
host-mediated assayEscherichia coli/mouse150 mg/kgMUREAV 164,19,1986
host-mediated assaySalmonella typhimurium/hamster150 mg/kgMUREAV 41,89,1976
host-mediated assaySalmonella typhimurium/guinea pig150 mg/kgMUREAV 41,89,1976
micronucleus testoral/rat500 mg/kgMUREAV 698,30,2010
mutation in microorganisms/Other microorganisms156 mg/L (-enzymatic activation step)MUREAV 173,233,1986
mutation in microorganisms/Other microorganisms1500 mg/L (+enzymatic activation step)MUREAV 173,233,1986
mutation in microorganisms/Salmonella typhimurium1 mg/plate (+enzymatic activation step)CRNGDP 5,391,1984
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)BIZNAT 97,137,1978
other mutation test systems/Bacillus subtilis10 mmol/LMUREAV 5,343,1968
other mutation test systemslymphocyte/human10 mmol/LMUREAV 50,251,1978
other mutation test systemsintraperitoneal/mouse14667 µg/kgNULSAK 22,96,1979
sister chromatid exchangeovary/hamster1 mmol/LMUREAV 68,351,1979
sister chromatid exchangelung/hamster10 mmol/LHUGEDQ 54,155,1980
specific locus testintraperitoneal/mouse100 mg/kgPJPPAA 31,689,1979
sperm morphologyintraperitoneal/mouse900 mg/kgREBPAT 13,1,1976
Unscheduled DNA Synthesisliver/human100 µmol/LCALEDQ 30,103,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 1848 mg/kg (1-21D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Delayed effects
IJEBA6 18,1104,1980
oral/rabbit 40 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
DPHFAK 23,383,1971
subcutaneous/mouse 160 mg/kg (6-13D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
GJMSA7 14,233,1965
subcutaneous/rat 2790 µg/kg (6-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
DPHFAK 23,383,1971
subcutaneous/rat 27900 µg/kg (6-14D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
DPHFAK 23,383,1971

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 2200 mg/kg/8W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
UICMAI 7,180,1967
intraperitoneal/mouse toxic dose: 2240 mg/kg/32W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JLCMAK 60,1025,1962
oral/mouse toxic dose: 9 gm/kg/17W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
IJCNAW 21,381,1978
oral/mouse toxic dose: 2240 mg/kg/4W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
BJCAAI 18,543,1964
oral/mouse toxic dose: 6720 mg/kg/32W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JLCMAK 60,1025,1962
oral/mouse lowest published toxic dose: 1892 mg/kg (multigenerations)Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
JCROD7 105,258,1983
oral/mouse lowest published toxic dose: 18524 mg/kg/84W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JCROD7 105,258,1983
oral/mouse toxic dose: 93 gm/kg/70W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CNREA8 26,1473,1966
oral/mouse toxic dose: 15 gm/kg/30W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GANNA2 51,83,1960
oral/mouse toxic dose: 27 gm/kg/49W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
JNCIAM 41,331,1968
oral/mouse toxic dose: 79576 mg/kg/98W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TUMOAB 56,315,1970
oral/mouse toxic dose: 8880 mg/kg/19W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GANNA2 50,107,1959
oral/rat lowest published toxic dose: 55 gm/kg/45W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
JNCIAM 41,331,1968
subcutaneous/mouse toxic dose: 269 mg/kg/21D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Liver: Tumors
JCROD7 96,163,1980
subcutaneous/mouse lowest published toxic dose: 5040 mg/kg/18W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GANNA2 51,83,1960
unreported route/mouse lowest published toxic dose: 27400 mg/kg/39W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
PAPOAC 12,53,1961

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 31362 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 57515 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 23200 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,543,1991
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 5,543,1991
In Vitro/Rat, liver tumor Inhibitor Concentration (50 percent kill): >2000 mg/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 5,543,1991
inhalation/rat lowest published toxic concentration: 11 mg/m3/4HBehavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition
TOVEFN (6),46,2000
inhalation/rat lowest published toxic concentration: 11 mg/m3/4HEndocrine: Other changes

Blood: Change in clotting factors
TOVEFN (6),46,2000
intracerebral/rabbit lethal dose (50 percent kill): >12 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intramuscular/guinea pig lethal dose (50 percent kill): 255 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intramuscular/mouse lethal dose (50 percent kill): 137 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
ARTUA4 65,376,1952
intramuscular/rabbit lethal dose (50 percent kill): 155 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intramuscular/rat lethal dose (50 percent kill): 400 mg/kgBehavioral: Convulsions or effect on seizure thresholdTHERAP 8,62,1953
intraperitoneal/cat lethal dose (50 percent kill): 325 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
KLWOAZ 30,959,1952
intraperitoneal/guinea pig lethal dose (50 percent kill): 195 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
KLWOAZ 30,959,1952
intraperitoneal/mammal (species unspecified) lethal dose (50 percent kill): 57.1 mg/kgTOVEFN (1),14,2001
intraperitoneal/mouse lethal dose (50 percent kill): 51.7 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOVEFN (6),46,2000
intraperitoneal/mouse lowest published toxic dose: 250 mg/kgBehavioral: Convulsions or effect on seizure thresholdPHREP* 61,245,2009
intraperitoneal/mouse lowest published toxic dose: 250 mg/kgJOETD7 76,145,2001
intraperitoneal/mouse lowest published toxic dose: 250 mg/kgBehavioral: Muscle contraction or spasticityJOETD7 76,145,2001
intraperitoneal/mouse lethal dose (50 percent kill): 100 mg/kgNTIS** AD277-689
intraperitoneal/rabbit lethal dose (50 percent kill): 147 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intraperitoneal/rat lethal dose (50 percent kill): 335 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intraperitoneal/rat lowest published toxic dose: 250 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)JPETAB 294,473,2000
intraperitoneal/rat lowest published toxic dose: 400 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
ARTODN 81,201,2007
intravenous/guinea pig lethal dose (50 percent kill): 220 mg/kgGastrointestinal: Hypermotility, diarrheaATXKA8 22,80,1966
intravenous/mouse lethal dose (50 percent kill): 149 mg/kgBehavioral: Convulsions or effect on seizure thresholdJPETAB 122,110,1958
intravenous/rabbit lethal dose (50 percent kill): 94 mg/kgBehavioral: Convulsions or effect on seizure thresholdARTUA4 65,376,1952
intravenous/rat lethal dose (50 percent kill): 365 mg/kgARZNAD 26,409,1976
oral/child lowest published toxic dose: 125 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
AEMED3 17,73,1988
oral/child lowest published toxic dose: 195 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Headache
JJTOEX 12,225,1999
oral/child lowest published toxic dose: 3600 mg/kg/43W- intermittentEye: Other eye effects

Behavioral: Tremor

Behavioral: Ataxia
CMAJAX 148,49,1993
oral/child lowest published toxic dose: 290 mg/kgBehavioral: Convulsions or effect on seizure thresholdCTOXAO 47,729,2009
oral/Dog lethal dose (50 percent kill): 50 mg/kgARTUA4 65,392,1952
oral/guinea pig lethal dose (50 percent kill): 255 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
oral/human lowest published lethal dose: 100 mg/kgPeripheral Nerve and Sensation: Structural change in nerve or sheathARDSBL 105,206,1972
oral/human lowest published toxic dose: 85 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JEMME* 16,57,1998
oral/infant lowest published toxic dose: 91 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
PEDIAU 95,700,1995
oral/mammal (species unspecified) lethal dose (50 percent kill): 189 mg/kgTOVEFN (1),14,2001
oral/man lowest published toxic dose: 430 mg/kgBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
NEURAI 20,299,1970
oral/man lowest published toxic dose: 39 mg/kg/9D- intermittentSkin: After systemic exposure: Dermatitis, otherSMJOAV 75,81,1982
oral/man lowest published toxic dose: 100 mg/kg/3W- continuousBehavioral: Anorexia (human)

Skin and Appendages: Other: Sweating

Kidney, Ureter, and Bladder: Other changes
ARDSBL 106,849,1972
oral/man lowest published lethal dose: 116 mg/kgBehavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema
JATOD3 16,57,1992
oral/man lowest published lethal dose: 523 mg/kg/17W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)
JAMAAP 176,877,1961
oral/mouse lethal dose (50 percent kill): 133 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
ARTUA4 65,376,1952
oral/mouse lethal dose (50 percent kill): 188.9 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOVEFN (6),46,2000
oral/rabbit lethal dose (50 percent kill): 250 mg/kgARZNAD 12,22,1962
oral/rat lethal dose (50 percent kill): 1250 mg/kgARZNAD 26,409,1976
oral/rat lethal dose (50 percent kill): 1097.7 mg/kgBehavioral: Convulsions or effect on seizure thresholdTOVEFN (6),46,2000
oral/woman lowest published toxic dose: 12 mg/kg/2D- intermittentBehavioral: Toxic psychosis

Behavioral: Ataxia
NEURAI 34,703,1984
oral/woman lowest published toxic dose: 11250 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
ANASAB 47,781,1992
oral/woman lowest published toxic dose: 90200 µg/kg/7D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Headache

Cardiac: EKG changes not diagnostic of above
PEDIAU 97,782,1996
oral/woman lowest published toxic dose: 99300 µg/kgBehavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
PEDIAU 95,700,1995
subcutaneous/guinea pig lethal dose (50 percent kill): 195 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
subcutaneous/mouse lethal dose (50 percent kill): 125 mg/kgBehavioral: Convulsions or effect on seizure thresholdYKKZAJ 81,1225,1961
subcutaneous/mouse lowest published toxic dose: 200 mg/kgBehavioral: Convulsions or effect on seizure thresholdEJPHAZ 519,31,2005
subcutaneous/rabbit lethal dose (50 percent kill): 135 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
subcutaneous/rat lethal dose (50 percent kill): 329 mg/kgJPETAB 119,444,1957
Tank with water/Zebrafish lowest published toxic concentration: 2.78 µmol/L 144HMusculoskeletal: Other changes

Skin and Appendages: Other glands
REPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 0.36 mmol/L 24HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 0.25 mmol/L 48HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 0.2 mmol/L 72HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012
Tank with water/Zebrafish lowest published toxic concentration: 0.05 mmol/L 144HRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 33,142,2012

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.12 mg/m3/122D- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Other changes
TOVEFN (6),46,2000
inhalation/rat lowest published toxic concentration: 0.12 mg/m3/122D- intermittentBlood: Change in clotting factorsTOVEFN (6),46,2000
intraperitoneal/rabbit lowest published toxic dose: 275 mg/kg/11D- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Changes in: P
DCTODJ 28,273,2005
intraperitoneal/rat lowest published toxic dose: 500 mg/kg/5D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
ARTODN 83,571,2009
intraperitoneal/rat lowest published toxic dose: 2100 mg/kg/21D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 264,185,2009
intraperitoneal/rat lowest published toxic dose: 280 mg/kg/14D- intermittentLiver: Change in gall bladder structure or function

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
AMBIEH 30,185,1985
intraperitoneal/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentLiver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FATOAO 49,86,1986
intraperitoneal/rat lowest published toxic dose: 700 mg/kg/14D- intermittentLiver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FATOAO 55,45,1992
oral/Dog lowest published toxic dose: 2300 mg/kg/17W- intermittentBrain and Coverings: Other degenerative changesTXAPA9 10,183,1967
oral/Dog lowest published toxic dose: 577 mg/kg/33D- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ARTUA4 65,392,1952
oral/Dog lowest published toxic dose: 325 mg/kg/13W- intermittentLiver: Other changesARTUA4 65,376,1952
oral/mouse lowest published toxic dose: 2100 mg/kg/14D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* IMM-96002
oral/mouse lowest published toxic dose: 1400 mg/kg/14D- intermittentEndocrine: Changes in spleen weight

Blood: Normocytic anemia

Immunological Including Allergic: Decrease in humoral immune response
NTPTR* IMM-96002
oral/mouse lowest published toxic dose: 700 mg/kg/14D- intermittentImmunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-96002
oral/rat lowest published toxic dose: 45 gm/kg/52W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainTXAPA9 8,325,1966
oral/rat lowest published toxic dose: 166 gm/kg/26W- intermittentPeripheral Nerve and Sensation: Structural change in nerve or sheath

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JACTDZ 14,328,1995
oral/rat lowest published toxic dose: 750 mg/kg/15D- intermittentBlood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Xanthine oxidases
TIHEEC 24,519,2008
unreported route/mouse lowest published toxic dose: 3300 mg/kg/22D- intermittentLiver: Changes in liver weightNTPTR* IMM-96012
unreported route/mouse lowest published toxic dose: 1200 mg/kg/8D- intermittentImmunological Including Allergic: Increase in humoral response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* IMM-96012
unreported route/mouse lowest published toxic dose: 2200 mg/kg/22D- intermittentBlood: Other changesNTPTR* IMM-96012
unreported route/mouse lowest published toxic dose: 550 mg/kg/22D- intermittentBlood: Changes in cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-96012
unreported route/mouse lowest published toxic dose: 550 mg/kg/22D- intermittentBlood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
NTPTR* IMM-96012
unreported route/mouse lowest published toxic dose: 1100 mg/kg/22D- intermittentImmunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decreased immune response
NTPTR* IMM-96012
unreported route/rat lowest published toxic dose: 400 mg/kg/4D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 -,56,2009

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 4,159,1974
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMSUDL 7,227,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,227,1987
TOXICOLOGY REVIEWCTOXAO 39,143,2001
TOXICOLOGY REVIEWAJHPA9 32,202,1975
TOXICOLOGY REVIEWCRTXB2 2,365,1973
TOXICOLOGY REVIEWMMWOAU 115,1685,1973
TOXICOLOGY REVIEWMUREAV 39,111,1977
TOXICOLOGY REVIEWMUREAV 488,151,2001
TOXICOLOGY REVIEWAPHRER 38,1074,2004
TOXICOLOGY REVIEWEMMUEG 43,143,2004
TOXICOLOGY REVIEWBPCEM* 16,105,2002
TOXICOLOGY REVIEWEJIME* 17,529,2006
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOPADD 33,63,2005
TOXICOLOGY REVIEWJAADDB 56,181,2007
TOXICOLOGY REVIEWHUTOX* -,429,1996
TOXICOLOGY REVIEWBLREV* 3,71,1989
TOXICOLOGY REVIEWCLLID* 11,549,2007
TOXICOLOGY REVIEWCOCPH* -,701,2008
TOXICOLOGY REVIEWCLLID* 13,277,2009
TOXICOLOGY REVIEWDERCL* 27,289,2009
TOXICOLOGY REVIEWCGHEP* 5,648,2007
TOXICOLOGY REVIEWNEUCL* 18,215,2000
TOXICOLOGY REVIEWNEUCL* 23,377,2005
TOXICOLOGY REVIEWMEDIAV 37,263,2009
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 750,1,2012
TOXICOLOGY REVIEWNRTXDN 33,605,2012
TOXICOLOGY REVIEWMUTAEX 27,387,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1139; Number of Industries 2; Total Number of Facilities 79; Number of Occupations 4; Total Number of Employees Exposed 2924; Total Number of Female Employees Exposed 1480
National Occupational Hazard Survey 1974Hazard Code A1139; Number of Industries 1; Total Number of Facilities 33; Number of Occupations 1; Total Number of Employees Exposed 297

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Body fluid assay; Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Inconclusive: Mouse spot test; Mouse specific locus
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-rabbit
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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