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Isonicotinic acid hydrazide

RTECS #: NS1751850

CAS #: 54-85-3


UPDATE: May 2009 MW: 137.16 MF: C6H7N3O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 4 - (Hydrazinocarbonyl) pyridine
  2. 4 - Pyridinecarboxylic acid, hydrazide
  3. 4 - Pyridinecarboxylic hydrazide
  4. 5015 RP
  5. Andrazide
  6. Antimicina
  7. Antituberkulosum
  8. Armazide
  9. Atcotibine
  10. Azuren
  11. BP 5015
  12. Cedin
  13. Cemidon
  14. Chemiazid
  15. Chemidon
  16. Cotinazin
  17. Defonin
  18. Dibutin
  19. Diforin
  20. Dinacrin
  21. Ditubin
  22. Ebidene
  23. Eralon
  24. Ertuban
  25. Eutizon
  26. Evalon
  27. FSR 3
  28. Fimalene
  29. GInk
  30. HIA
  31. Hidranizil
  32. Hidrasonil
  33. Hidrulta
  34. Hidrun
  35. Hycozid
  36. Hydrazid
  37. Hyozid
  38. Hyzyd
  39. I.A.I.
  40. IN - 73
  41. INAH
  42. INH
  43. Ido - tebin
  44. Idrazide dell'acido isonicotinico (Italian)
  45. Idrazil
  46. Inizid
  47. Iscotin
  48. Isidrina
  49. Ismazide
  50. Isobicina
  51. Isocid
  52. Isocidene
  53. Isocotin
  54. Isolyn
  55. Isonerit
  56. Isonex
  57. Isoniazid
  58. Isoniazide
  59. Isonicazide
  60. Isonicid
  61. Isonicotil
  62. Isonico
  63. Isonicotan
  64. Isonicotinhydrazid
  65. Isonicotinyl hydrazide
  66. Isonicotinoyl hydrazide
  67. Isonicotinoylhydrazine
  68. Isonicotinsaeurehydrazid (German)
  69. Isonide
  70. Isonidrin
  71. Isonikazid
  72. Isonilex
  73. Isonin
  74. Isonindon
  75. Isonirit
  76. Isoniton
  77. Isonizide
  78. Isotebe
  1. Isotebezid
  2. Isotinyl
  3. Isozide
  4. Isozyd
  5. L 1945
  6. Laniazid
  7. Mybasan
  8. NSC 9659
  9. Neo - tizide
  10. Neoteben
  11. Neoxin
  12. Neumandin
  13. Nevin
  14. Niadrin
  15. Nicazide
  16. Nicetal
  17. Nicizina
  18. Niconyl
  19. Nicotibina
  20. Nicozide
  21. Nidaton
  22. Nidrazid
  23. Nikozid
  24. Niplen
  25. Nitadon
  26. Niteban
  27. Nydrazid
  28. Pelazid
  29. Phthisen
  30. Preparation 6424
  31. Pycazide
  32. Pyrizidin
  33. RU - EF - TB
  34. Raumanon
  35. Razide
  36. Retozide
  37. Rifamate
  38. Rimicid
  39. Rimifon
  40. Rimitsid
  41. Robisellin
  42. Roxifen
  43. Sanohidrazina
  44. Sauterazid
  45. Stanozide
  46. TB - Phlogin
  47. TB - Razide
  48. TB - Vis
  49. Tebecid
  50. Tebenic
  51. Tebexin
  52. Tebilon
  53. Tebos
  54. Teebaconin
  55. Tekazin
  56. Tibazide
  57. Tibinide
  58. Tibison
  59. Tibivis
  60. Tibizide
  61. Tibusan
  62. Tisin
  63. Tisiodrazida
  64. Tizide
  65. Tubazid
  66. Tubazide
  67. Tubeco
  68. Tubercid
  69. Tuberian
  70. Tubicon
  71. Tubomel
  72. Tyvid
  73. USAF CB - 2
  74. Unicozyde
  75. Vazadrine
  76. Vederon
  77. Zinadon
  78. Zonazide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour moderate TXAPA9 4,44,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium
90 mg/kg MUREAV 56,289,1978
cytogenetic analysis oral
hamster
10 mg/kg/2 week- intermittent HUGEDQ 42,9,1978
cytogenetic analysis hamster lung 1 gm/L AMONDS 3,253,1980
cytogenetic analysis hamster fibroblast 3 gm/L ESKHA5 (96),55,1978
cytogenetic analysis human lymphocyte 7 mmol/L HUGEDQ 52,309,1979
cytogenetic analysis human leukocyte 5 gm/L EXPEAM 29,1433,1973
cytogenetic analysis human bone marrow 5 mg/L CRSBAW 169,1326,1975
cytogenetic analysis intraperitoneal
mouse
14,667 g/kg NULSAK 22,96,1979
cytogenetic analysis mouse Ascites tumor 1 mmol/L PHARAT 32,178,1977
cytogenetic analysis mouse mammary gland 3,200 mol/L/24 hour- continuous JTSCDR 5,141,1980
cytogenetic analysis intraperitoneal
mouse
14,700 g/kg NULSAK 22,96,1979
cytogenetic analysis oral
rat
900 mg/kg/12 week- intermittent HUGEDQ 42,9,1978
cytogenetic analysis intravenous
rat
65 mg/kg LANCAO 2,93,1971
DNA adduct oral
mouse
28 mg/kg HUTODJ 6,153,1987
DNA damage intraperitoneal
mouse
960 mol/kg CNREA8 41,1469,1981
DNA inhibition hamster ovary 10 mmol/L MUREAV 50,251,1978
DNA inhibition human HeLa cell 300 mmol/L JOUOD4 8(Suppl),291,1986
DNA inhibition human fibroblast 10 mmol/L MUREAV 89,9,1981
DNA inhibition intraperitoneal
mouse
90 mg/kg IJEBA6 19,939,1981
DNA repair Escherichia coli 187 g/well MUREAV 133,161,1984
DNA repair other microorganisms 7 mg/plate BIZNAT 95,463,1976
unscheduled DNA synthesis human liver 100 mol/L CALEDQ 30,103,1986
host-mediated assay guinea pig
Salmonella typhimurium
150 mg/kg MUREAV 41,89,1976
host-mediated assay hamster
Salmonella typhimurium
150 mg/kg MUREAV 41,89,1976
host-mediated assay mouse
Salmonella typhimurium
150 mg/kg MUREAV 41,89,1976
host-mediated assay mouse
Escherichia coli
150 mg/kg MUREAV 164,19,1986
host-mediated assay rat
Salmonella typhimurium
150 mg/kg MUREAV 41,89,1976
mutation in microorganisms other microorganisms 156 mg/L (-enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms other microorganisms 1,500 mg/L (+enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) CRNGDP 5,391,1984
mutation in microorganisms Salmonella typhimurium 50 g/plate (-enzymatic activation step) BIZNAT 97,137,1978
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mmol/L MUREAV 91,215,1981
other mutation test systems Bacillus subtilis 10 mmol/L MUREAV 5,343,1968
other mutation test systems human lymphocyte 10 mmol/L MUREAV 50,251,1978
other mutation test systems intraperitoneal
mouse
14,667 g/kg NULSAK 22,96,1979
sister chromatid exchange hamster ovary 1 mmol/L MUREAV 68,351,1979
sister chromatid exchange hamster lung 10 mmol/L HUGEDQ 54,155,1980
specific locus test intraperitoneal
mouse
100 mg/kg PJPPAA 31,689,1979
sperm morphology intraperitoneal
mouse
900 mg/kg REBPAT 13,1,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,848 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Delayed effects
IJEBA6 18,1104,1980
oral
rabbit
lowest published toxic dose: 40 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
DPHFAK 23,383,1971
subcutaneous
mouse
lowest published toxic dose: 160 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
GJMSA7 14,233,1965
subcutaneous
rat
lowest published toxic dose: 2,790 g/kg (6-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
DPHFAK 23,383,1971
subcutaneous
rat
lowest published toxic dose: 27,900 g/kg (6-14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
DPHFAK 23,383,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 2,200 mg/kg/8 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease
UICMAI 7,180,1967
intraperitoneal
mouse
toxic dose : 2,240 mg/kg/32 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JLCMAK 60,1025,1962
oral
mouse
lowest published toxic dose: 1,892 mg/kg (multigenerations) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
JCROD7 105,258,1983
oral
mouse
lowest published toxic dose: 18,524 mg/kg/84 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JCROD7 105,258,1983
oral
mouse
toxic dose : 93 gm/kg/70 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CNREA8 26,1473,1966
oral
mouse
toxic dose : 15 gm/kg/30 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GANNA2 51,83,1960
oral
mouse
toxic dose : 27 gm/kg/49 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
JNCIAM 41,331,1968
oral
mouse
toxic dose : 79,576 mg/kg/98 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TUMOAB 56,315,1970
oral
mouse
toxic dose : 8,880 mg/kg/19 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GANNA2 50,107,1959
oral
mouse
toxic dose : 9 gm/kg/17 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
IJCNAW 21,381,1978
oral
mouse
toxic dose : 2,240 mg/kg/4 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
BJCAAI 18,543,1964
oral
mouse
toxic dose : 6,720 mg/kg/32 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
JLCMAK 60,1025,1962
oral
rat
lowest published toxic dose: 55 gm/kg/45 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
JNCIAM 41,331,1968
subcutaneous
mouse
lowest published toxic dose: 5,040 mg/kg/18 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
GANNA2 51,83,1960
subcutaneous
mouse
toxic dose : 269 mg/kg/21 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Liver: Tumors
JCROD7 96,163,1980
unreported route
mouse
lowest published toxic dose: 27,400 mg/kg/39 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma
PAPOAC 12,53,1961


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
rabbit
lethal dose (50 percent kill): >12 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
inhalation
rat
lowest published toxic concentration: 11 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition
TOVEFN (6),46,2000
inhalation
rat
lowest published toxic concentration: 11 mg/m3/4 hour Endocrine: Other changes

Blood: Change in clotting factors
TOVEFN (6),46,2000
intramuscular
guinea pig
lethal dose (50 percent kill): 255 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intramuscular
mouse
lethal dose (50 percent kill): 137 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
ARTUA4 65,376,1952
intramuscular
rat
lethal dose (50 percent kill): 400 mg/kg Behavioral: Convulsions or effect on seizure threshold THERAP 8,62,1953
intramuscular
rabbit
lethal dose (50 percent kill): 155 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intraperitoneal
cat
lethal dose (50 percent kill): 325 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
KLWOAZ 30,959,1952
intraperitoneal
guinea pig
lethal dose (50 percent kill): 195 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
KLWOAZ 30,959,1952
intraperitoneal
mammal (species unspecified)
lethal dose (50 percent kill): 57.1 mg/kg N/R TOVEFN (1),14,2001
intraperitoneal
mouse
lethal dose (50 percent kill): 100 mg/kg N/R NTIS** AD277-689
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg N/R JOETD7 76,145,2001
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Behavioral: Muscle contraction or spasticity JOETD7 76,145,2001
intraperitoneal
mouse
lethal dose (50 percent kill): 51.7 mg/kg Behavioral: Convulsions or effect on seizure threshold TOVEFN (6),46,2000
intraperitoneal
rat
lethal dose (50 percent kill): 335 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intraperitoneal
rat
lowest published toxic dose: 250 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JPETAB 294,473,2000
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
ARTODN 81,201,2007
intraperitoneal
rabbit
lethal dose (50 percent kill): 147 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
intravenous
guinea pig
lethal dose (50 percent kill): 220 mg/kg Gastrointestinal: Hypermotility, diarrhea ATXKA8 22,80,1966
intravenous
mouse
lethal dose (50 percent kill): 149 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 122,110,1958
intravenous
rat
lethal dose (50 percent kill): 365 mg/kg N/R ARZNAD 26,409,1976
intravenous
rabbit
lethal dose (50 percent kill): 94 mg/kg Behavioral: Convulsions or effect on seizure threshold ARTUA4 65,376,1952
oral
child
lowest published toxic dose: 195 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Headache
JJTOEX 12,225,1999
oral
child
lowest published toxic dose: 3,600 mg/kg/43 week- intermittent Eye: Other eye effects

Behavioral: Tremor

Behavioral: Ataxia
CMAJAX 148,49,1993
oral
child
lowest published toxic dose: 125 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
AEMED3 17,73,1988
oral
dog
lethal dose (50 percent kill): 50 mg/kg N/R ARTUA4 65,392,1952
oral
guinea pig
lethal dose (50 percent kill): 255 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
oral
human
lowest published lethal dose: 100 mg/kg Peripheral Nerve and Sensation: Structural change in nerve or sheath ARDSBL 105,206,1972
oral
human
lowest published toxic dose: 85 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
JEMME* 16,57,1998
oral
infant
lowest published toxic dose: 91 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
PEDIAU 95,700,1995
oral
mammal (species unspecified)
lethal dose (50 percent kill): 189 mg/kg N/R TOVEFN (1),14,2001
oral
man
lowest published lethal dose: 523 mg/kg/17 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)
JAMAAP 176,877,1961
oral
man
lowest published toxic dose: 430 mg/kg Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold
NEURAI 20,299,1970
oral
man
lowest published toxic dose: 39 mg/kg/9 day- intermittent Skin: After systemic exposure: Dermatitis, other SMJOAV 75,81,1982
oral
man
lowest published toxic dose: 100 mg/kg/3 week- continuous Behavioral: Anorexia (human)

Skin and Appendages: Other: Sweating

Kidney, Ureter, and Bladder: Other changes
ARDSBL 106,849,1972
oral
man
lowest published lethal dose: 116 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema
JATOD3 16,57,1992
oral
mouse
lethal dose (50 percent kill): 133 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
ARTUA4 65,376,1952
oral
mouse
lethal dose (50 percent kill): 188.9 mg/kg Behavioral: Convulsions or effect on seizure threshold TOVEFN (6),46,2000
oral
rat
lethal dose (50 percent kill): 1,250 mg/kg N/R ARZNAD 26,409,1976
oral
rat
lethal dose (50 percent kill): 1,097.7 mg/kg Behavioral: Convulsions or effect on seizure threshold TOVEFN (6),46,2000
oral
rabbit
lethal dose (50 percent kill): 250 mg/kg N/R ARZNAD 12,22,1962
oral
woman
lowest published toxic dose: 90,200 g/kg/7 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Cardiac: EKG changes not diagnostic of above
PEDIAU 97,782,1996
oral
woman
lowest published toxic dose: 99,300 g/kg Behavioral: Hallucinations, distorted perceptions

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
PEDIAU 95,700,1995
oral
woman
lowest published toxic dose: 12 mg/kg/2 day- intermittent Behavioral: Toxic psychosis

Behavioral: Ataxia
NEURAI 34,703,1984
oral
woman
lowest published toxic dose: 11,250 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
ANASAB 47,781,1992
subcutaneous
guinea pig
lethal dose (50 percent kill): 195 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952
subcutaneous
mouse
lethal dose (50 percent kill): 125 mg/kg Behavioral: Convulsions or effect on seizure threshold YKKZAJ 81,1225,1961
subcutaneous
mouse
lowest published toxic dose: 200 mg/kg Behavioral: Convulsions or effect on seizure threshold EJPHAZ 519,31,2005
subcutaneous
rat
lethal dose (50 percent kill): 329 mg/kg N/R JPETAB 119,444,1957
subcutaneous
rabbit
lethal dose (50 percent kill): 135 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
SZTPA5 9,226,1952


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 0.12 mg/m3/122 day- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Other changes
TOVEFN (6),46,2000
inhalation
rat
lowest published toxic concentration: 0.12 mg/m3/122 day- intermittent Blood: Change in clotting factors TOVEFN (6),46,2000
intraperitoneal
rat
lowest published toxic dose: 280 mg/kg/14 day- intermittent Liver: Change in gall bladder structure or function

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
AMBIEH 30,185,1985
intraperitoneal
rat
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FATOAO 49,86,1986
intraperitoneal
rat
lowest published toxic dose: 700 mg/kg/14 day- intermittent Liver: Liver function tests impaired

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FATOAO 55,45,1992
intraperitoneal
rabbit
lowest published toxic dose: 275 mg/kg/11 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Changes in: P
DCTODJ 28,273,2005
oral
dog
lowest published toxic dose: 2,300 mg/kg/17 week- intermittent Brain and Coverings: Other degenerative changes TXAPA9 10,183,1967
oral
dog
lowest published toxic dose: 577 mg/kg/33 day- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ARTUA4 65,392,1952
oral
dog
lowest published toxic dose: 325 mg/kg/13 week- intermittent Liver: Other changes ARTUA4 65,376,1952
oral
mouse
lowest published toxic dose: 2,100 mg/kg/14 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* IMM-96002
oral
mouse
lowest published toxic dose: 1,400 mg/kg/14 day- intermittent Endocrine: Changes in spleen weight

Blood: Normocytic anemia

Immunological Including Allergic: Decrease in humoral immune response
NTPTR* IMM-96002
oral
mouse
lowest published toxic dose: 700 mg/kg/14 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-96002
oral
rat
lowest published toxic dose: 45 gm/kg/52 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXAPA9 8,325,1966
oral
rat
lowest published toxic dose: 166 gm/kg/26 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JACTDZ 14,328,1995
unreported route
mouse
lowest published toxic dose: 3,300 mg/kg/22 day- intermittent Liver: Changes in liver weight NTPTR* IMM-96012
unreported route
mouse
lowest published toxic dose: 1,200 mg/kg/8 day- intermittent Immunological Including Allergic: Increase in humoral response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTPTR* IMM-96012
unreported route
mouse
lowest published toxic dose: 2,200 mg/kg/22 day- intermittent Blood: Other changes NTPTR* IMM-96012
unreported route
mouse
lowest published toxic dose: 550 mg/kg/22 day- intermittent Blood: Changes in cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-96012
unreported route
mouse
lowest published toxic dose: 550 mg/kg/22 day- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
NTPTR* IMM-96012
unreported route
mouse
lowest published toxic dose: 1,100 mg/kg/22 day- intermittent Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Decreased immune response
NTPTR* IMM-96012


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 4,159,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,227,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,227,1987
TOXICOLOGY REVIEW
CTOXAO 39,143,2001
TOXICOLOGY REVIEW
AJHPA9 32,202,1975
TOXICOLOGY REVIEW
CRTXB2 2,365,1973
TOXICOLOGY REVIEW
MMWOAU 115,1685,1973
TOXICOLOGY REVIEW
MUREAV 39,111,1977
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
APHRER 38,1074,2004
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
APHRER 38,1074,2004
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
TOPADD 33,63,2005
TOXICOLOGY REVIEW
JAADDB 56,181,2007
TOXICOLOGY REVIEW
HUTOX* -,429,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1139;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 297
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1139;
Number of Industries 2;
Total Number of Facilities 79;
Number of Occupations 4;
Total Number of Employees Exposed 2,924;
Total Number of Female Employees Exposed 1,480


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-rabbit
EPA GENETOX PROGRAM 1988, Inconclusive: Body fluid assay; Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Inconclusive: Mouse spot test; Mouse specific locus
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

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APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
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ARTUA4 American Review of Tuberculosis. (New York, NY) V.1-70, 1917-54. For publisher information, see ARDSBL.
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ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN.
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BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GJMSA7 Gunma Journal of Medical Sciences. (Maebashi, Japan) V.1-17, 1952-69. Discontinued.
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HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
HUTOX*
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
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IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
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Used as an antitubercular, antibacterial and anti-actinomycotic agent

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 7640-37-1
ALT CAS #: 37271-10-6
ALT CAS #: 41466-07-3
ALT CAS #: 62229-51-0
Click Here for Additional Information about RTECS

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