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Registry of Toxic Effects of Chemical Substances (RTECS)

Isocyanic acid, cyclohexyl ester

RTECS #

NQ8650000

CAS #

3173-53-3

Updated

November 2009

Molecular Weight

125.19

Molecular Formula

C7H11NO

Synonyms

Cyclohexane, isocyanato- (9CI)
Isocyanatocyclohexane
NSC 87419

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium150 µg/plate (+enzymatic activation step)ABCHA6 44,3017,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 13 mg/kgNCISP* JAN1986
intravenous/mouse lethal dose (50 percent kill): 18 mg/kgCSLNX* NX#04502
oral/rat lethal dose (50 percent kill): 560 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Gastritis
HPV191 -,-,2001
skin/rabbit lowest published lethal dose: 3160 mg/kgBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV191 -,-,2001
skin/rabbit lowest published lethal dose: 500 mg/kgLung, Thorax, or Respiration: DyspneaHPV191 -,-,2001

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code T0838; Number of Industries 3; Total Number of Facilities 48; Number of Occupations 3; Total Number of Employees Exposed 457

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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