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Registry of Toxic Effects of Chemical Substances (RTECS)

Isocyanic acid, butyl ester

RTECS #

NQ8250000

CAS #

111-36-4

Updated

August 2009

Molecular Weight

99.15

Molecular Formula

C5H9NO

Synonyms

1-Isocyanatobutane
Butane, 1-isocyanato- (9CI)
Butyl isocyanate

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 680 mg/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 20(3),53,1976
inhalation/rat lethal concentration (50 percent kill): 3 gm/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 20(3),53,1976
intravenous/mouse lethal dose (50 percent kill): 1 mg/kgCSLNX* NX#05701
oral/guinea pig lethal dose (50 percent kill): 250 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 20(3),53,1976
oral/mouse lethal dose (50 percent kill): 150 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 20(3),53,1976
oral/rat lethal dose (50 percent kill): 600 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis
GTPZAB 20(3),53,1976
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0528347
skin/rabbit lowest published lethal dose: 6 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)
NTIS** OTS0528441

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 15 mg/m3/6H/5D- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 66,118,1992

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFCTOD7 46,813,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code 83605; Number of Industries 1; Total Number of Facilities 23; Number of Occupations 1; Total Number of Employees Exposed 585

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8877
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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