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Isobutyraldehyde

RTECS #: NQ4025000

CAS #: 78-84-2


UPDATE: February 2009 MW: 72.12 MF: C4H8O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Methylpropanal
  2. 2 - Methyl - 1 - propanal
  3. 2 - Methylpropionaldehyde
  4. Isobutanal
  5. Isobutaldehyde
  6. Isobutyraldehyd (Czech)
  7. Isobutyral
  8. Isobutyric aldehyde
  9. Isobutyryl aldehyde
  1. Isopropyl aldehyde
  2. Isopropyl formaldehyde
  3. Methyl propanal
  4. NCI - C60968
  5. Propanal, 2 - methyl -
  6. Propionaldehyde, 2 - methyl -
  7. Valine aldehyde
  8. alpha - Methylpropionaldehyde


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
397 mg open irritation test mild UCDS** 11/3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 7,500 mg/m3/6 hour (6-15 day pregnant) Reproductive: Other effects on female NTIS** OTS0573565


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 39,500 mg/m3/2 hour Behavioral: Excitement

Eye: Other eye effects

Lung, Thorax, or Respiration: Pleural thickening
GISAAA 37(5),104,1972
inhalation
mouse
lethal concentration (50 percent kill): 39,500 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse
VCVGK* -,375,1984
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R AMIHBC 10,61,1954
inhalation
rat
lethal concentration (50 percent kill): 39,500 mg/m3 N/R TOVEFN (6),37,2001
oral
mouse
lethal dose (50 percent kill): >5,080 mg/kg N/R TOVEFN (6),37,2001
oral
rat
lethal dose (50 percent kill): 960 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Necrotic changes

Blood: Hemorrhage
GISAAA 37(5),104,1972
oral
rat
lethal dose (50 percent kill): 3,700 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse
VCVGK* -,375,1984
oral
rat
lethal dose (50 percent kill): 3,700 mg/kg N/R TOVEFN (6),37,2001
skin
rabbit
lethal dose (50 percent kill): 7,130 ÁL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 42,136,1998
inhalation
mouse
lowest published toxic concentration: 1,000 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 42,136,1998
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects TOSCF2 42,136,1998
inhalation
rat
lowest published toxic concentration: 4,000 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 42,136,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
MUREAV 566,49,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84782;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 3;
Total Number of Employees Exposed 705
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84782;
Number of Industries 3;
Total Number of Facilities 32;
Number of Occupations 2;
Total Number of Employees Exposed 4,114;
Total Number of Female Employees Exposed 655


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the synthesis of PANTOTHENIC ACID, VALINE, LEUCINE and CELLULOSE ESTER
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in the synthesis of PANTOTHENIC ACID, VALINE, LEUCINE and CELLULOSE ESTER

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Primary Irritant

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