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Registry of Toxic Effects of Chemical Substances (RTECS)

Isobutyraldehyde

RTECS #

NQ4025000

CAS #

78-84-2

Updated

April 2012

Molecular Weight

72.12

Molecular Formula

C4H8O

Synonyms

2-Methyl-1-propanal
2-Methylpropanal
2-Methylpropionaldehyde
alpha-Methylpropionaldehyde
Isobutaldehyde
Isobutanal
Isobutyral
Isobutyraldehyd (Czech)
Isobutyric aldehyde
Isobutyryl aldehyde
Isopropyl aldehyde
Isopropyl formaldehyde
Methyl propanal
NCI-C60968
Propanal, 2-methyl-
Propionaldehyde, 2-methyl-
Valine aldehyde

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 397 mg open irritation test mildUCDS** 11/3/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/mouse10 mmol/LMUREAV 715,25,2011
specific locus testother cell types/human530 mg/L/16H (-enzymatic activation step)MUREAV 724,76,2011
specific locus testother cell types/human721 mg/L/16H (+enzymatic activation step)MUREAV 724,76,2011

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 7500 mg/m3/6H (6-15D pregnant)Reproductive: Other effects on femaleNTIS** OTS0573565

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 39500 mg/m3/2HBehavioral: Excitement

Eye: Other eye effects

Lung, Thorax, or Respiration: Pleural thickening
GISAAA 37(5),104,1972
inhalation/mouse lethal concentration (50 percent kill): 39500 mg/m3/2HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse
VCVGK* -,375,1984
inhalation/rat lethal concentration (50 percent kill): 39500 mg/m3TOVEFN (6),37,2001
inhalation/rat Lowest published lethal concentration: 8000 ppm/4HAMIHBC 10,61,1954
oral/mouse lethal dose (50 percent kill): >5080 mg/kgTOVEFN (6),37,2001
oral/rat lethal dose (50 percent kill): 960 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Necrotic changes

Blood: Hemorrhage
GISAAA 37(5),104,1972
oral/rat lethal dose (50 percent kill): 3700 mg/kgTOVEFN (6),37,2001
oral/rat lethal dose (50 percent kill): 3700 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse
VCVGK* -,375,1984
skin/rabbit lethal dose (50 percent kill): 7130 µL/kgAMIHBC 10,61,1954

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1000 ppm/6H/2Y- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 42,136,1998
inhalation/mouse lowest published toxic concentration: 1000 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 42,136,1998
inhalation/rat lowest published toxic concentration: 500 ppm/6H/2Y- intermittentOlfaction: Other olfaction effectsTOSCF2 42,136,1998
inhalation/rat lowest published toxic concentration: 4000 ppm/6H/13W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOSCF2 42,136,1998

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWMUREAV 653,99,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84782; Number of Industries 3; Total Number of Facilities 32; Number of Occupations 2; Total Number of Employees Exposed 4114; Total Number of Female Employees Exposed 655
National Occupational Hazard Survey 1974Hazard Code 84782; Number of Industries 1; Total Number of Facilities 21; Number of Occupations 3; Total Number of Employees Exposed 705

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
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