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Indium chloride

RTECS #: NL1400000

CAS #: 10025-82-8


UPDATE: May 2009 MW: 221.17 MF: Cl3In


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Indium trichloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage mammal (species unspecified) lymphocyte 40 mol/L JCHODP 7,411,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lowest published toxic dose: 0.8 mg(In)/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TCMUD8 20,219,2000
intravenous
mouse
lowest published toxic dose: 1.6 mg(In)/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TCMUD8 20,219,2000
intravenous
rat
lowest published toxic dose: 400 g/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TCMUD8 18,231,1998
intravenous
rat
lowest published toxic dose: 0.4 mg(In)/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TCMUD8 20,219,2000
intravenous
rat
lowest published toxic dose: 0.4 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TCMUD8 18,231,1998
oral
mouse
lowest published toxic dose: 2,500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 27,140,1995
oral
mouse
lowest published toxic dose: 2,250 mg/kg (6-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TOXID9 12,103,1992
oral
rat
lowest published toxic dose: 2 gm/kg (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JTEHF8 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
JTEHF8 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 1,500 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 6,000 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 400 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral
rabbit
lowest published toxic dose: 3 gm/kg (6-20 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHF8 59,27,2000
oral
rabbit
lowest published toxic dose: 1,500 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JTEHD6 59,27,2000
oral
rabbit
lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral
rabbit
lowest published toxic dose: 3,000 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 4,950 g/kg N/R COREAF 256,1043,1963
intraperitoneal
rat
lethal dose (50 percent kill): 2,370 g/kg N/R NIIRDN -,136,1990
intravenous
mouse
lethal dose (50 percent kill): 11,900 g/kg N/R NIIRDN -,136,1990
intravenous
mouse
lowest published toxic dose: 16.5 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) HBTME* -,569,2007
intravenous
rat
lethal dose (50 percent kill): 4,460 g/kg N/R NIIRDN -,136,1990
intravenous
rat
lowest published toxic dose: 3.6 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) HBTME* -,569,2007
intravenous
rabbit
lowest published lethal dose: 0.64 mg/kg N/R VCVN1* -,232,1988
subcutaneous
mouse
lowest published lethal dose: 60 mg/kg N/R EQSSDX 1,1,1975
subcutaneous
rat
lowest published lethal dose: 10 mg/kg Olfaction: Other olfaction effects

Skin and Appendages: Other: Hair
JIHTAB 24,243,1942
subcutaneous
rat
lowest published lethal dose: 10 mg/kg N/R VCVN1* -,232,1988
subcutaneous
rabbit
lowest published lethal dose: 2 mg/kg N/R VCVN1* -,232,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 200 mg/kg/2 day- intermittent Behavioral: Food intake (animal) JTEHD6 59,27,2000
oral
rat
lowest published toxic dose: 6,000 mg/kg/15 day- intermittent Brain and Coverings: Changes in brain weight

Gastrointestinal: Changes in pancreatic weight

Liver: Changes in liver weight
JTEHD6 59,27,2000
oral
rabbit
lowest published toxic dose: 3,000 mg/kg/15 day- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 59,27,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg(In)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HBTME* ,569,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg(In)/m3 CFRGBR 29,1926.55,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(In)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(In)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(In)/m3 (dust), OCT 2002
Occupational Exposure Limit - JAPAN Occupational Exposure Limit-B 3 g(In)/L, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg(In)/m3;
short term exposure limit 0.3 mg(In)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg(In)/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(In)/m3, JAN2002
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(In)/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(In)/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg(In)/m3;
short term exposure limit 0.3 mg(In)/m3, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5168;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 14


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
HBTME*
JCHODP Journal of Clinical Hematology and Oncology. (Cancer Center at Wadley Institutes, POB 35988, Dallas, TX 75235) V.5(3)- 1975-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

NIOSH PROFILE (INDIUM AND ITS COMPOUNDS), SRC, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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