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Registry of Toxic Effects of Chemical Substances (RTECS)

Indium chloride

RTECS #

NL1400000

CAS #

10025-82-8

Updated

September 201

Molecular Weight

221.17

Molecular Formula

Cl3In

Synonyms

Indium trichloride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/mammal (species unspecified)40 µmol/LJCHODP 7,411,1976

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravenous/rat 400 µg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TCMUD8 18,231,1998
intravenous/rat 0.4 mg(In)/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TCMUD8 20,219,2000
intravenous/mouse 0.8 mg(In)/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TCMUD8 20,219,2000
intravenous/mouse 1.6 mg(In)/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TCMUD8 20,219,2000
intravenous/rat 0.4 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TCMUD8 18,231,1998
oral/rat 2 gm/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JTEHF8 59,27,2000
oral/rat 400 mg/kg (12D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
JTEHF8 59,27,2000
oral/mouse 2500 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 27,140,1995
oral/rabbit 3 gm/kg (6-20D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHF8 59,27,2000
oral/mouse 2250 mg/kg (6-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)TOXID9 12,103,1992
oral/rat 400 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral/rat 400 mg/kg (11D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 59,27,2000
oral/rat 400 mg/kg (12D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 59,27,2000
oral/rat 400 mg/kg (13D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral/rat 400 mg/kg (14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral/rat 400 mg/kg (15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral/rat 1500 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JTEHD6 59,27,2000
oral/rat 3000 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 59,27,2000
oral/rat 3000 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJTEHD6 59,27,2000
oral/rat 6000 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
JTEHD6 59,27,2000
oral/rabbit 1500 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJTEHD6 59,27,2000
oral/rabbit 3000 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral/rabbit 3000 mg/kg (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000
oral/rat 400 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JTEHD6 59,27,2000
oral/rat 400 mg/kg (9D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 59,27,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 4950 µg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 2370 µg/kgNIIRDN -,136,1990
intravenous/mouse lethal dose (50 percent kill): 11900 µg/kgNIIRDN -,136,1990
intravenous/mouse lowest published toxic dose: 16.5 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)HBTME* -,569,2007
intravenous/rabbit lowest published lethal dose: 0.64 mg/kgVCVN1* -,232,1988
intravenous/rat lowest published toxic dose: 3.6 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)HBTME* -,569,2007
intravenous/rat lethal dose (50 percent kill): 4460 µg/kgNIIRDN -,136,1990
subcutaneous/mouse lowest published lethal dose: 60 mg/kgEQSSDX 1,1,1975
subcutaneous/rabbit lowest published lethal dose: 2 mg/kgVCVN1* -,232,1988
subcutaneous/rat lowest published lethal dose: 10 mg/kgVCVN1* -,232,1988
subcutaneous/rat lowest published lethal dose: 10 mg/kgOlfaction: Other olfaction effects

Skin and Appendages: Other: Hair
JIHTAB 24,243,1942

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 3000 mg/kg/15D- intermittentBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 59,27,2000
oral/rat lowest published toxic dose: 200 mg/kg/2D- intermittentBehavioral: Food intake (animal)JTEHD6 59,27,2000
oral/rat lowest published toxic dose: 6000 mg/kg/15D- intermittentBrain and Coverings: Changes in brain weight

Gastrointestinal: Changes in pancreatic weight

Liver: Changes in liver weight
JTEHD6 59,27,2000

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(In)/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWHBTME* ,569,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(In)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(In)/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg(In)/m3 (dust), MAY2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit-B 3 µg(In)/L, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 mg(In)/m3;short term exposure limit 0.3 mg(In)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(In)/m3, JAN2002
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(In)/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg(In)/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.1 mg(In)/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 mg(In)/m3;short term exposure limit 0.3 mg(In)/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 mg(In)/m3CFRGBR 29,1926.55,1994

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5168; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 14

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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