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Registry of Toxic Effects of Chemical Substances (RTECS)

Indeno(1,2,3-cd)pyrene

RTECS #

NK9300000

CAS #

193-39-5

Updated

October 2012

Molecular Weight

276.34

Molecular Formula

C22H12

Synonyms

1,10-(1,2-Phenylene)pyrene
1,10-(ortho-Phenylene)pyrene
2,3-o-Phenylenepyrene
2,3-Phenylenepyrene
IP
o-Phenylenepyrene
RCRA waste number U137

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Escherichia coli952.5 µg/L/3H (+enzymatic activation step)MUREAV 515,85,2002
DNA Damagefibroblast/human1 µmol/L/24HMUREAV 547,109,2004
morphological transformlung/hamster100 µg/LTXCYAC 17,149,1980
mutation in mammalian somatic cellslymphocyte/human50 µg/LMUREAV 371,123,1996
mutation in microorganisms/Salmonella typhimurium3 µg/plate/48H (-enzymatic activation step)FCTXAV 17,141,1979
mutation in microorganisms/Salmonella typhimurium0.5 nmol/plate/48H (-enzymatic activation step)MUREAV 557,99,2004

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 4150 µg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
JJIND8 71,539,1983
implant/rat toxic dose: 20750 µg/kgTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
JJIND8 71,539,1983
implant/rat toxic dose: 5 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumors at site of application
50NNAZ 7,571,1983
skin/mouse lowest published toxic dose: 40 mg/kg/20D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
CRNGDP 7,1761,1986
subcutaneous/mouse lowest published toxic dose: 72 mg/kg/9W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application
AICCA6 19,490,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration Low: 1 µmol/L/14HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXCYAC 279,36,2011

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 32,373,1983
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 32,373,1983
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWMUREAV 540,89,2003
TOXICOLOGY REVIEWMUREAV 558,155,2004
TOXICOLOGY REVIEWMUREAV 558,7,2004
TOXICOLOGY REVIEWMUREAV 544,397,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUREAV 567,401,2004
TOXICOLOGY REVIEWMUREAV 567,151,2004
TOXICOLOGY REVIEWMUREAV 613,103,2006
TOXICOLOGY REVIEWMUREAV 636,4,2007
TOXICOLOGY REVIEWMUREAV 727,1,2011

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
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