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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Imidazolidinimine, 1-((6-chloro-3-pyridinyl)methyl)-N-nitro-

RTECS #

NJ0560000

CAS #

138261-41-3

Updated

April 2013

Molecular Weight

255.69

Molecular Formula

C9H10ClN5O2

Synonyms

1-((6-Chloro-3-pyridinyl)methyl)-N-nitro-2-imidazolidinimine
1-(6-Chloro-3-pyridylmethyl)-N-nitroimidazolidin-3-ylideneamine
Admire
BAY-NTN 33893
Confidor
Confidor 200 SL
Confidor SL
Gaucho
Imidacloprid
Imidacloprid technical grade
Merit
Merit (insecticide)
NTN 33893
Provado

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/human20 µmol/L/24H (+/-enzymatic activation step)MUREAV 672,40,2009
micronucleus testlymphocyte/human20 µmol/L/24H (+enzymatic activation step)MUREAV 672,40,2009
micronucleus testoral/rat300 mg/kgMUREAV 634,32,2007

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 337 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral
TOXID9 44,197,2005
oral/rat 1100 mg/kg (6-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFEREAC 69,25095,2004
oral/rabbit 936 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FEREAC 69,25095,2004
oral/mammal (species unspecified) 52 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FEREAC 66,56279,2001
oral/mammal (species unspecified) 1100 mg/kg (6-16D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFEREAC 66,56279,2001
oral/mammal (species unspecified) 936 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 66,56279,2001
oral/rat 1000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)HBPTO* 2,1127,2001
oral/rabbit 936 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HBPTO* 2,1127,2001
oral/rabbit 936 mg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
FEREAC 68,10464,2003
oral/rat 52 mg/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEREAC 68,10464,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 5.33 gm/m3/4HFEREAC 66,56278,2001
inhalation/rat lethal concentration (50 percent kill): >5323 mg/m3AGJAEP (63),15,1993
inhalation/rat lethal concentration (50 percent kill): >5.33 gm/m3/4HFEREAC 69,25095,2004
intraperitoneal/mouse lethal dose (50 percent kill): 35 mg/kgPCBPBS 58,77,1997
intrauterine/man lowest published lethal dose: 4.12 mL/kgEye: Mydriasis (pupilliary dilation)

Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Respiratory obstruction
AJEMEN 26,634e1,2008
intrauterine/man lowest published toxic dose: 1 mL/kgEye: Mydriasis (pupilliary dilation)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
AJEMEN 27,256e5,2009
oral/man lowest published toxic dose: 127.1 mg/kgEye: Mydriasis (pupilliary dilation)

Cardiac: Change in rate

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
AJEMEN 27,256.e5,2009
oral/man lowest published toxic dose: 137 mg/kgLung, Thorax, or Respiration: Cough

Gastrointestinal: Ulceration or bleeding from duodeum

Gastrointestinal: Nausea or vomiting
JTCTDW 39,617,2001
oral/mouse lethal dose (50 percent kill): 98 mg/kgNNGADV 19,S209,1994
oral/mouse lowest published toxic dose: 14.976 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 48,215,2010
oral/quail lowest published lethal dose: 31 mg/kgARPTDI 45,247,2005
oral/rat lethal dose (50 percent kill): 410 mg/kgAGJAEP (63),15,1993
oral/rat lowest published lethal dose: 450 mg/kgARPTDI 45,247,2005
oral/rat lowest published toxic dose: 42 mg/kgBehavioral: Change in motor activity (specific assay)FEREAC 68,35303,2003
oral/rat lethal dose (20 percent kill): 400 mg/kgHBPTO* 2,1125,2001
oral/rat lowest published toxic dose: 315 mg/kgOlfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor
HBPTO* 2,1125,2001
oral/rat lowest published lethal dose: 307 mg/kgBehavioral: Tremor

Behavioral: Change in psychophysiological tests

Nutritional and Gross Metabolic: Body temperature decrease
HBPTO* 2,1129,2001
oral/woman lowest published toxic dose: 0.384 mg/kgCardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
AJEMEN 24,883,2006
skin/rat lethal dose (50 percent kill): >5000 mg/kgFEREAC 69,25095,2004
Tank with water/Daphnia lowest published toxic concentration: 5.5 mg/L/21DReproductive: Effects on fertility: Other measures of fertilityEESADV 74,99,2011
Tank with water/Daphnia Lowest published lethal concentration: 10 mg/L/21DEESADV 74,99,2011
unreported route/rat lowest published toxic dose: 42 mg/kgBehavioral: Change in motor activity (specific assay)FEREAC 70,3634,2005
unreported route/rat lowest published toxic dose: 42 mg/kgBehavioral: IrritabilityFEREAC 66,56277,2001
unreported route/rat lethal dose (50 percent kill): 449 mg/kgTOXID9 44,197,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 1.26 gm/kg/4W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1126,2001
oral/Dog lowest published toxic dose: 1.365 gm/kg/13W- continuousBehavioral: TremorHBPTO* 2,1126,2001
oral/Dog lowest published toxic dose: 22736 mg/kg/52W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)FEREAC 69,25095,2004
oral/mouse lowest published toxic dose: 149.76 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1126,2001
oral/mouse lowest published toxic dose: 200.02 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1126,2001
oral/mouse lowest published toxic dose: 302.22 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Other changes
HBPTO* 2,1126,2001
oral/mouse lowest published toxic dose: 309.52 gm/kg/2Y- continuousBehavioral: Fluid intake

Liver: Other changes
HBPTO* 2,1126,2001
oral/rabbit lowest published toxic dose: 936 mg/kg/13D- intermittentReproductive: Other effects on female

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HBPTO* 2,1127,2001
oral/rabbit lowest published toxic dose: 312 mg/kg/13D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1127,2001
oral/rabbit lowest published toxic dose: 936 mg/kg/13D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FEREAC 69,25095,2004
oral/rat lowest published toxic dose: 5697 mg/kg/90D- continuousBehavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FEREAC 69,25095,2004
oral/rat lowest published toxic dose: 4550 mg/kg/13W- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 36(1 Pt2),64,1997
oral/rat lowest published toxic dose: 38.4 gm/kg/13W- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
HBPTO* 2,1126,2001
oral/rat lowest published toxic dose: 27.3 gm/kg/13W- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HBPTO* 2,1126,2001
oral/rat lowest published toxic dose: 34.272 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1126,2001
oral/rat lowest published toxic dose: 49.056 gm/kg/2Y- continuousEndocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 2,1126,2001
oral/rat lowest published toxic dose: 69.216 gm/kg/2Y- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HBPTO* 2,1126,2001
oral/rat lowest published toxic dose: 11.424 gm/kg/2Y- continuousEndocrine: Other changesHBPTO* 2,1126,2001
oral/rat lowest published toxic dose: 4.445 gm/kg/127D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
HBPTO* 2,1127,2001
oral/rat lowest published toxic dose: 6237 mg/kg/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 68,10464,2003
oral/rat lowest published toxic dose: 110 mg/kg/11D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainFEREAC 69,25095,2004
oral/rat lowest published toxic dose: 1800 mg/kg/90D- intermittentBrain and Coverings: Other degenerative changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
FCTOD7 48,1185,2010
oral/rat lowest published toxic dose: 900 mg/kg/90D- intermittentBehavioral: Change in motor activity (specific assay)FCTOD7 48,1185,2010
oral/rat lowest published toxic dose: 1800 mg/kg/90D- intermittentEndocrine: Change in LH

Endocrine: Other changes

Reproductive: Maternal effects: Ovaries, fallopian tubes
FCTOD7 49,3086,2011

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,196,2005
TOXICOLOGY REVIEWTOXIA6 49,413,2007
TOXICOLOGY REVIEWFEREAC 71,46110,2006
TOXICOLOGY REVIEWFEREAC 72,33907,2007
TOXICOLOGY REVIEWREPTED 26,13,2008
TOXICOLOGY REVIEWFCTOD7 47,2906,2009
TOXICOLOGY REVIEWMUTAEX 21,343,2006

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,376,1998
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