CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




2 - Imidazolidinimine, 1 - ( (6 - chloro - 3 - pyridinyl) methyl) - N - nitro -

RTECS #: NJ0560000

CAS #: 138261-41-3

UPDATE: February 2009 MW: 255.69 MF: C9H10ClN5O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. REFERENCES:

SYNONYMS:

  1. 1 - ( (6 - Chloro - 3 - pyridinyl) methyl) - N - nitro - 2 - imidazolidinimine
  2. 1 - (6 - Chloro - 3 - pyridylmethyl) - N - nitroimidazolidin - 3 - ylideneamine
  3. Admire
  4. BAY - NTN 33893
  5. Confidor
  6. Confidor 200 SL
  7. Confidor SL
  1. Gaucho
  2. Imidacloprid
  3. Imidacloprid technical grade
  4. Merit
  5. Merit (insecticide)
  6. NTN 33893
  7. Provado


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test oral
rat 		300 mg/kg MUREAV 634,32,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 337 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Behavioral 		TOXID9 44,197,2005
oral
mammal (species unspecified) 		lowest published toxic dose: 52 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FEREAC 66,56279,2001
oral
mammal (species unspecified) 		lowest published toxic dose: 1,100 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FEREAC 66,56279,2001
oral
mammal (species unspecified) 		lowest published toxic dose: 936 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FEREAC 66,56279,2001
oral
rat 		lowest published toxic dose: 1,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) HBPTO* 2,1127,2001
oral
rat 		lowest published toxic dose: 52 mg/kg (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FEREAC 68,10464,2003
oral
rat 		lowest published toxic dose: 1,100 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FEREAC 69,25095,2004
oral
rabbit 		lowest published toxic dose: 936 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Abortion

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		HBPTO* 2,1127,2001
oral
rabbit 		lowest published toxic dose: 936 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) 		FEREAC 68,10464,2003
oral
rabbit 		lowest published toxic dose: 936 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		FEREAC 69,25095,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 5.33 gm/m3/4 hour N/R FEREAC 66,56278,2001
inhalation
rat 		lethal concentration (50 percent kill): >5,323 mg/m3 N/R AGJAEP (63),15,1993
inhalation
rat 		lethal concentration (50 percent kill): >5.33 gm/m3/4 hour N/R FEREAC 69,25095,2004
intraperitoneal
mouse 		lethal dose (50 percent kill): 35 mg/kg N/R PCBPBS 58,77,1997
oral
man 		lowest published toxic dose: 137 mg/kg Lung, Thorax, or Respiration: Cough

Gastrointestinal: Ulceration or bleeding from duodeum

Gastrointestinal: Nausea or vomiting 		CTOXAO 39,617,2001
oral
mouse 		lethal dose (50 percent kill): 98 mg/kg N/R NNGADV 19,S209,1994
oral
quail 		lowest published lethal dose: 31 mg/kg N/R ARPTDI 45,247,2005
oral
rat 		lethal dose (50 percent kill): 410 mg/kg N/R AGJAEP (63),15,1993
oral
rat 		lethal dose (20 percent kill): 400 mg/kg N/R HBPTO* 2,1125,2001
oral
rat 		lowest published toxic dose: 315 mg/kg Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		HBPTO* 2,1125,2001
oral
rat 		lowest published lethal dose: 307 mg/kg Behavioral: Tremor

Behavioral: Change in psychophysiological tests

Nutritional and Gross Metabolic: Body temperature decrease 		HBPTO* 2,1129,2001
oral
rat 		lowest published toxic dose: 42 mg/kg Behavioral: Change in motor activity (specific assay) FEREAC 68,35303,2003
oral
rat 		lowest published lethal dose: 450 mg/kg N/R ARPTDI 45,247,2005
oral
woman 		lowest published toxic dose: 0.384 mg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		AJEMEN 24,883,2006
skin
rat 		lethal dose (50 percent kill): >5,000 mg/kg N/R FEREAC 69,25095,2004
unreported route
rat 		lowest published toxic dose: 42 mg/kg Behavioral: Irritability FEREAC 66,56277,2001
unreported route
rat 		lethal dose (50 percent kill): 449 mg/kg N/R TOXID9 44,197,2005
unreported route
rat 		lowest published toxic dose: 42 mg/kg Behavioral: Change in motor activity (specific assay) FEREAC 70,3634,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 1.26 gm/kg/4 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1126,2001
oral
dog 		lowest published toxic dose: 1.365 gm/kg/13 week- continuous Behavioral: Tremor HBPTO* 2,1126,2001
oral
dog 		lowest published toxic dose: 22,736 mg/kg/52 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) FEREAC 69,25095,2004
oral
mouse 		lowest published toxic dose: 149.76 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1126,2001
oral
mouse 		lowest published toxic dose: 200.02 gm/kg/2 year- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1126,2001
oral
mouse 		lowest published toxic dose: 302.22 gm/kg/2 year- continuous Behavioral: Food intake (animal)

Behavioral: Fluid intake

Liver: Other changes 		HBPTO* 2,1126,2001
oral
mouse 		lowest published toxic dose: 309.52 gm/kg/2 year- continuous Behavioral: Fluid intake

Liver: Other changes 		HBPTO* 2,1126,2001
oral
rat 		lowest published toxic dose: 4,550 mg/kg/13 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 36(1 Pt2),64,1997
oral
rat 		lowest published toxic dose: 38.4 gm/kg/13 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		HBPTO* 2,1126,2001
oral
rat 		lowest published toxic dose: 27.3 gm/kg/13 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		HBPTO* 2,1126,2001
oral
rat 		lowest published toxic dose: 34.272 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain HBPTO* 2,1126,2001
oral
rat 		lowest published toxic dose: 49.056 gm/kg/2 year- continuous Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1126,2001
oral
rat 		lowest published toxic dose: 69.216 gm/kg/2 year- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		HBPTO* 2,1126,2001
oral
rat 		lowest published toxic dose: 11.424 gm/kg/2 year- continuous Endocrine: Other changes HBPTO* 2,1126,2001
oral
rat 		lowest published toxic dose: 4.445 gm/kg/127 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		HBPTO* 2,1127,2001
oral
rat 		lowest published toxic dose: 6,237 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 68,10464,2003
oral
rat 		lowest published toxic dose: 110 mg/kg/11 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,25095,2004
oral
rat 		lowest published toxic dose: 5,697 mg/kg/90 day- continuous Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,25095,2004
oral
rabbit 		lowest published toxic dose: 936 mg/kg/13 day- intermittent Reproductive: Other effects on female

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		HBPTO* 2,1127,2001
oral
rabbit 		lowest published toxic dose: 312 mg/kg/13 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		HBPTO* 2,1127,2001
oral
rabbit 		lowest published toxic dose: 936 mg/kg/13 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FEREAC 69,25095,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,196,2005
TOXICOLOGY REVIEW
TOXIA6 49,413,2007
TOXICOLOGY REVIEW
FEREAC 71,46110,2006
TOXICOLOGY REVIEW
FEREAC 72,33907,2007
TOXICOLOGY REVIEW
FEREAC 72,33907,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Active registration RBREV* -,376,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as a chloronicotinyl insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us