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1H - Imidazole, 1 - (2 - (2,4 - dichlorophenyl) - 2 - (2 - propenyloxy) ethyl) -

RTECS #: NI4776000

CAS #: 35554-44-0


UPDATE: February 2009 MW: 297.20 MF: C14H14Cl2N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. (+ - ) - 1 - (beta - (Allyloxy) - 2,4 - dichlorophenethyl) imidazole
  2. 1 - (2 - (2,4 - Dichlorophenyl) - 2 - (2 - propenyloxy) ethyl) - 1H - imidazole
  3. 1 - (2 - (2,4 - Dichlorphenyl) - 2 - (2 - propenyloxy) aethyl) - 1H - imidazol (German)
  4. CGA 41333
  5. Chloramizol
  6. Deccozil S 75
  1. Enilconazole
  2. Eniloconazol (SP)
  3. Fungaflor
  4. Imazalil
  5. R 23979


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
49 mg moderate ARZNAD 31,309,1981


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2,240 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
ARZNAD 31,309,1981
oral
rat
lowest published toxic dose: 560 mg/kg (16-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) ARZNAD 31,309,1981
oral
rat
lowest published toxic dose: 4,160 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) ARZNAD 31,309,1981
oral
rabbit
lowest published toxic dose: 8,190 g/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 31,309,1981
oral
rabbit
lowest published toxic dose: 32,500 g/kg (6-18 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) ARZNAD 31,309,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 16 gm/m3/4 hour N/R PEMNDP 9,482,1991
intraperitoneal
rat
lethal dose (50 percent kill): 155 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Skin and Appendages: Other: Hair
ARZNAD 31,309,1981
oral
dog
lethal dose (50 percent kill): >640 mg/kg Gastrointestinal: Hypermotility, diarrhea ARZNAD 31,309,1981
oral
rat
lethal dose (50 percent kill): 227 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Skin and Appendages: Other: Hair
ARZNAD 31,309,1981
skin
rat
lethal dose (50 percent kill): 4,200 mg/kg N/R PEMNDP 9,482,1991
skin
rabbit
lethal dose (50 percent kill): 4,200 mg/kg N/R 85JFAN A230,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 3,640 mg/kg/2 year- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARZNAD 31,309,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
FEREAC 71,24615,2006
TOXICOLOGY REVIEW
FEREAC 71,54423,2006
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
JTPAE7 19,1,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,185,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

Used as a fungicide

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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