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Registry of Toxic Effects of Chemical Substances (RTECS)

1H-Imidazole, 1-(2-(2,4-dichlorophenyl)-2-(2-propenyloxy)ethyl)-

RTECS #

NI4776000

CAS #

35554-44-0

Updated

July 2012

Molecular Weight

297.20

Molecular Formula

C14H14Cl2N2O

Synonyms

(+-)-1-(beta-(Allyloxy)-2,4-dichlorophenethyl)imidazole
1-(2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl)-1H-imidazole
1-(2-(2,4-Dichlorphenyl)-2-(2-propenyloxy)aethyl)-1H-imidazol (German)
CGA 41333
Chloramizol
Deccozil S 75
Enilconazole
Eniloconazol (SP)
Fungaflor
Imazalil
R 23979

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 49 mg moderateARZNAD 31,309,1981

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2240 mg/kg (16-22D preg/21D after birth)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
ARZNAD 31,309,1981
oral/rat 560 mg/kg (16-22D preg/21D after birth)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)ARZNAD 31,309,1981
oral/rat 4160 mg/kg (multigenerations)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)ARZNAD 31,309,1981
oral/rabbit 8190 µg/kg (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)ARZNAD 31,309,1981
oral/rabbit 32500 µg/kg (6-18D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)ARZNAD 31,309,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endocrine tumor Inhibitor Concentration (50 percent kill): 0.13 µmol/L/24HEndocrine: Other changesTXCYAC 275,21,2010
inhalation/rat lethal concentration (50 percent kill): 16 gm/m3/4HPEMNDP 9,482,1991
intraperitoneal/rat lethal dose (50 percent kill): 155 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia

Skin and Appendages: Other: Hair
ARZNAD 31,309,1981
oral/Dog lethal dose (50 percent kill): >640 mg/kgGastrointestinal: Hypermotility, diarrheaARZNAD 31,309,1981
oral/rat lethal dose (50 percent kill): 227 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia

Skin and Appendages: Other: Hair
ARZNAD 31,309,1981
skin/rabbit lethal dose (50 percent kill): 4200 mg/kg85JFAN A230,1983
skin/rat lethal dose (50 percent kill): 4200 mg/kgPEMNDP 9,482,1991

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/Dog lowest published toxic dose: 3640 mg/kg/2Y- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARZNAD 31,309,1981

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFEREAC 71,24615,2006
TOXICOLOGY REVIEWFEREAC 71,54423,2006
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWJTPAE7 19,1,2006
TOXICOLOGY REVIEWFCTOD7 46,813,2008
TOXICOLOGY REVIEWMUTAEX 26,19,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,185,1998

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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