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Imidazole

RTECS #: NI3325000

CAS #: 288-32-4


UPDATE: May 2005 MW: 68.09 MF: C3H4N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3 - Diaza - 2,4 - cyclopentadiene
  2. 1,3 - Diazole
  3. Formamidine, N,N' - vinylene -
  4. Glioksal (Polish)
  5. Glyoxalin
  6. Glyoxaline
  1. Imidazol
  2. Iminazole
  3. Imutex
  4. Miazole
  5. Pyrro (b) monazole
  6. USAF EK - 4733


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition human other cell types 1 mmol/L JIDEAE 65,400,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 150 mg/kg (1 day male) Reproductive: Paternal effects: Impotence NLETDU 12,69,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 300 mg/kg N/R NTIS** AD277-689
intravenous
mouse
lethal dose (50 percent kill): 475 mg/kg Behavioral: Convulsions or effect on seizure threshold ARZNAD 33,716,1983
oral
guinea pig
lethal dose (50 percent kill): 760 mg/kg N/R PREPAB 67,295,1993
oral
mammal (species unspecified)
lethal dose (50 percent kill): 1 gm/kg N/R PCOC** -,608,1966
oral
mouse
lethal dose (50 percent kill): 880 mg/kg N/R GWXXBX #3046325
oral
rat
lethal dose (50 percent kill): 220 mg/kg N/R PREPAB 67,295,1993
subcutaneous
cat
lowest published lethal dose: 125 mg/kg Behavioral: Food intake (animal)

Behavioral: Rigidity (includes catalepsy)

Nutritional and Gross Metabolic: Body temperature decrease
AEXPBL 84,155,1918
subcutaneous
dog
lethal dose (50 percent kill): 28 mg/kg N/R PREPAB 67,295,1993
subcutaneous
mouse
lethal dose (50 percent kill): 817 mg/kg N/R JPETAB 119,444,1957
subcutaneous
rat
lethal dose (50 percent kill): 626 mg/kg N/R JPETAB 119,444,1957


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TPHSDY 23,83,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1601;
Number of Industries 3;
Total Number of Facilities 158;
Number of Occupations 5;
Total Number of Employees Exposed 1,401
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1601;
Number of Industries 3;
Total Number of Facilities 313;
Number of Occupations 4;
Total Number of Employees Exposed 3,009;
Total Number of Female Employees Exposed 2,411


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NLETDU Neuroendocrinology Letters. (Brain Research Promotion, D-7400, Tubingen, Germany) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PREPAB Przeglad Epidemiologiczny. (Panstwowy Zaklad Wydawnictw Lekarskich, ul. Dluga 38-40, 00-238 Warsaw, Poland) V.1- 1947-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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