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Registry of Toxic Effects of Chemical Substances (RTECS)

Imidazole

RTECS #

NI3325000

CAS #

288-32-4

Updated

July 2011

Molecular Weight

68.09

Molecular Formula

C3H4N2

Synonyms

1,3-Diaza-2,4-cyclopentadiene
1,3-Diazole
Formamidine, N,N'-vinylene-
Glioksal (Polish)
Glyoxalin
Glyoxaline
Imidazol
Iminazole
Imutex
Miazole
Pyrro(b)monazole
USAF EK-4733

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionother cell types/human1 mmol/LJIDEAE 65,400,1975

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 150 mg/kg (1D male)Reproductive: Paternal effects: ImpotenceNLETDU 12,69,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 45 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/mouse lethal dose (50 percent kill): 300 mg/kgNTIS** AD277-689
intravenous/mouse lethal dose (50 percent kill): 475 mg/kgBehavioral: Convulsions or effect on seizure thresholdARZNAD 33,716,1983
oral/guinea pig lethal dose (50 percent kill): 760 mg/kgPREPAB 67,295,1993
oral/mammal (species unspecified) lethal dose (50 percent kill): 1 gm/kgPCOC** -,608,1966
oral/mouse lethal dose (50 percent kill): 880 mg/kgGWXXBX #3046325
oral/rat lethal dose (50 percent kill): 220 mg/kgPREPAB 67,295,1993
subcutaneous/cat lowest published lethal dose: 125 mg/kgBehavioral: Food intake (animal)

Behavioral: Rigidity (includes catalepsy)

Nutritional and Gross Metabolic: Body temperature decrease
AEXPBL 84,155,1918
subcutaneous/Dog lethal dose (50 percent kill): 28 mg/kgPREPAB 67,295,1993
subcutaneous/mouse lethal dose (50 percent kill): 817 mg/kgJPETAB 119,444,1957
subcutaneous/rat lethal dose (50 percent kill): 626 mg/kgJPETAB 119,444,1957

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTPHSDY 23,83,2002
TOXICOLOGY REVIEWNBREV* 5,1,1981

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1601; Number of Industries 3; Total Number of Facilities 313; Number of Occupations 4; Total Number of Employees Exposed 3009; Total Number of Female Employees Exposed 2411
National Occupational Hazard Survey 1974Hazard Code M1601; Number of Industries 3; Total Number of Facilities 158; Number of Occupations 5; Total Number of Employees Exposed 1401

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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