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Registry of Toxic Effects of Chemical Substances (RTECS)

Hypochlorous acid, sodium salt

RTECS #

NH3486300

CAS #

7681-52-9; 8007-59-8

Updated

December 2012

Molecular Weight

74.44

Molecular Formula

ClO·Na

Synonyms

Antiformin
B-K liquid
Carrel-dakin solution
Chloros
Chlorox
Clorox
Dakins solution
Deosan
Hyclorite
Hypochlorite solution containing >7% avaliable chlorine by wt. (UN1791)
Javex
Klorocin
Milton
Neo-cleaner
Neoseptal CL
Parozone
Purin B
Sodium chloride oxide
Sodium hypochlorite
Sodium oxychloride
Surchlor

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 10 mg moderateTXAPA9 55,501,1980
eye /rabbit 1.31 mg mildJTPAE7 29,308,2001
skin /human 4%/48HJIDEAE 11,45,1984

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysismultiple/non-mammalian species120 µg/LMUREAV 319,223,1993
Cytogenetic Analysislymphocyte/human100 ppm/24HARMCAH 21,409,1970
Cytogenetic Analysislung/hamster100 mg/LATSUDG 4,41,1980
Cytogenetic Analysisembryo/hamster1300 µmol/L/24HMUREAV 603,111,2006
Cytogenetic Analysisembryo/hamster65 µmol/L/3HMUREAV 603,111,2006
DNA Damageleukocyte/mouse160 µmol/L/10MTXCYAC 221,166,2006
DNA Damagemultiple/other fish1.24 mg/L/3HMUREAV 557,119,2004
DNA Damageother cell types/non-mammalian species10 mg/L/1HMUREAV 537,81,2003
DNA Damage/Escherichia coli420 µmol/LAIPAAV 114,595,1968
DNA inhibitionfibroblast/human0.0005 pphCBINA8 139,265,2002
DNA repair/Escherichia coli20 µg/discMUREAV 41,61,1976
micronucleus testmultiple/other fish0.55 mg/L/20D-continuousMUREAV 557,119,2004
micronucleus testmultiple/non-mammalian species200 ppbMUTAEX 4,170,1989
micronucleus testmultiple/other fish1.24 mg/L/20D-continuousMUREAV 729,81,2012
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)AMONDS 3,253,1980
phage inhibition capacity/Escherichia coli103 µg/wellMUREAV 260,349,1991
sister chromatid exchangeembryo/human149 mg/LSNSHBT (20),574,1980

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 5.4 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, lung tumor Inhibitor Concentration Low: 400 µmol/L/24HIn Vitro Toxicity Studies: Cell counting

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TXCYAC 270,112,2010
In Vitro/Human, lung tumor Inhibitor Concentration (25 percent kill): 564.9 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 270,112,2010
In Vitro/Human, lung tumor Inhibitor Concentration (25 percent kill): 496.1 µmol/L/24HIn Vitro Toxicity Studies: Cell countingTXCYAC 270,112,2010
In Vitro/Human, lung tumor Inhibitor Concentration Low: 500 µmol/L/24HIn Vitro Toxicity Studies: Apoptosis in vitro

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TXCYAC 270,112,2010
In Vitro/Human, lung tumor Inhibitor Concentration Low: 500 µmol/L/6HBiochemical: Metabolism (intermediary): Effect on mitochondrial functionTXCYAC 270,112,2010
In Vitro/Human, lung tumor Inhibitor Concentration Low: 100 µmol/L/24HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.TXCYAC 270,112,2010
In Vitro/Human, lung tumor Inhibitor Concentration Low: 250 µmol/L/1HIn Vitro Toxicity Studies: Other assaysTXCYAC 270,112,2010
intraperitoneal/rat lowest published toxic dose: 65.12 µg/kgLung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Cutaneous sensitization (experimental)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
JJATDK 20,431,2000
intravenous/man lowest published toxic dose: 45 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Nausea or vomiting
AEMED3 21,1394,1992
oral/mouse lethal dose (50 percent kill): 5800 mg/kgBehavioral: Change in motor activity (specific assay)

Gastrointestinal: Other changes
SKEZAP 27,553,1986
oral/woman lowest published toxic dose: 1 gm/kgBehavioral: Somnolence (general depressed activity)

Vascular: BP lowering not characterized in autonomic section

Skin: After topical application: Corrosive
HUTODJ 7,37,1988
Tank with water/other fish Inhibitor Concentration Low: 1.24 mg/L/10DBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
MUREAV 729,81,2012

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 47.96 mg/kg/11D- intermittentBlood: Tumors

Immunological Including Allergic: Autoimmune (multiple organ involvement)
JJATDK 20,431,2000
intraperitoneal/rat lowest published toxic dose: 26.05 mg/kg/7D- intermittentBlood: Tumors

Immunological Including Allergic: Autoimmune (multiple organ involvement)
JJATDK 20,431,2000
intraperitoneal/rat lowest published toxic dose: 26.05 mg/kg/9D- intermittentBlood: Tumors

Immunological Including Allergic: Autoimmune (multiple organ involvement)
JJATDK 20,431,2000
oral/rat lowest published toxic dose: 140 mg/kg/9W- continuousEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 44,257,1987

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 52,159,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 52,159,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 52,159,1991
TOXICOLOGY REVIEWMUREAV 564,179,2004
TOXICOLOGY REVIEWCHHSA* 8,24,2001
TOXICOLOGY REVIEWENTOX* -,317,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHUTOX* -,671,1996
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWMUREAV 681,80,2009
TOXICOLOGY REVIEWMUREAV 723,108,2011
TOXICOLOGY REVIEWMUREAV 751,15,2012

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,148,1998

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 69090; Number of Industries 168; Total Number of Facilities 23747; Number of Occupations 132; Total Number of Employees Exposed 562423; Total Number of Female Employees Exposed 265913
National Occupational Hazard Survey 1974Hazard Code 69090; Number of Industries 202; Total Number of Facilities 70228; Number of Occupations 111; Total Number of Employees Exposed 556864

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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