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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydroxylamine, sulfate (2:1)

RTECS #

NC5425000

CAS #

10039-54-0

Updated

February 2007

Molecular Weight

164.16

Molecular Formula

H3NO·1/2H2O4S

Synonyms

Bis(hydroxylamine) sulfate
Hydroxylamine neutral sulfate
Hydroxylamine, sulfate
Hydroxylammonium sulfate
Oxammonium sulfate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/Drosophila melanogaster5000 ppmCARYAB 31,1,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 68.1 mg/m3Behavioral: Alteration of classical conditioning

Vascular: Other changes
TOVEFN (1),41,2002
intraperitoneal/mouse lowest published lethal dose: 102 mg/kgTXAPA9 23,288,1972
oral/guinea pig lethal dose (50 percent kill): 910 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis
GISAAA 56(12),26,1991
oral/mouse lethal dose (50 percent kill): 1345 mg/kgTOVEFN (1),41,2002
oral/mouse lethal dose (50 percent kill): 980 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis
GISAAA 56(12),26,1991
oral/rat lethal dose (50 percent kill): 842 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
MTPEEI (7),37,1994
oral/rat lethal dose (50 percent kill): 1000 mg/kgTOVEFN (1),41,2002
skin/rabbit lowest published lethal dose: 100 mg/kgLung, Thorax, or Respiration: Cyanosis

Skin: After topical application: Corrosive

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 8,583,1987
unreported route/guinea pig lethal dose (50 percent kill): 1000 mg/kgTOVEFN (1),41,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 3000 mg/kg/30D- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in other cell count (unspecified)
TOVEFN (1),41,2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1488; Number of Industries 19; Total Number of Facilities 1603; Number of Occupations 20; Total Number of Employees Exposed 18175; Total Number of Female Employees Exposed 7954

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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