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Hydroxylamine, sulfate (2:1)

RTECS #: NC5425000

CAS #: 10039-54-0

UPDATE: February 2007 MW: 164.16 MF: H3NO•1/2H2O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Bis (hydroxylamine) sulfate
  2. Hydroxylamine, sulfate
  3. Hydroxylamine neutral sulfate
  1. Hydroxylammonium sulfate
  2. Oxammonium sulfate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
Drosophila melanogaster 		5,000 ppm CARYAB 31,1,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 68.1 mg/m3 Behavioral: Alteration of classical conditioning

Vascular: Other changes 		TOVEFN (1),41,2002
intraperitoneal
mouse 		lowest published lethal dose: 102 mg/kg N/R TXAPA9 23,288,1972
oral
guinea pig 		lethal dose (50 percent kill): 910 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 56(12),26,1991
oral
mouse 		lethal dose (50 percent kill): 980 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Cyanosis 		GISAAA 56(12),26,1991
oral
mouse 		lethal dose (50 percent kill): 1,345 mg/kg N/R TOVEFN (1),41,2002
oral
rat 		lethal dose (50 percent kill): 842 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression 		MTPEEI (7),37,1994
oral
rat 		lethal dose (50 percent kill): 1,000 mg/kg N/R TOVEFN (1),41,2002
skin
rabbit 		lowest published lethal dose: 100 mg/kg Lung, Thorax, or Respiration: Cyanosis

Skin: After topical application: Corrosive

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 8,583,1987
unreported route
guinea pig 		lethal dose (50 percent kill): 1,000 mg/kg N/R TOVEFN (1),41,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in other cell count (unspecified) 		TOVEFN (1),41,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1488;
Number of Industries 19;
Total Number of Facilities 1,603;
Number of Occupations 20;
Total Number of Employees Exposed 18,175;
Total Number of Female Employees Exposed 7,954


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a raw material for preparation of intermediate chemicals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
CARYAB Caryologia. (Via G. LaPira 4, 50121 Florence, Italy) V.1- 1948-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. (Mezhdunarodnaya Kniga, ul.B. Yakimanka, 39 117049 Moscow, Russia) No.1- 1993-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a raw material for preparation of intermediate chemicals

RTECS Compound Description:
   Mutagen

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