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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydroxylamine, hydrochloride

RTECS #

NC3675000

CAS #

5470-11-1

Updated

July 2011

Molecular Weight

69.50

Molecular Formula

ClH·H3NO

Synonyms

Hydroxyamine hydrochloride
Hydroxyammonium chloride
Hydroxylamine chloride
Hydroxylamine chloride (1:1)
Hydroxylammonium chloride
Oxammonium hydrochloride

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisparenteral/grasshopper2500 µgPISCAD 59(Pt3),480,1972
Cytogenetic Analysisleukocyte/human25 mg/LHEREAY 69,19,1971
Cytogenetic Analysisembryo/mouse72 µmol/LJNCIAM 32,667,1964
Cytogenetic Analysisother cell types/hamster72 µmol/LJNCIAM 32,667,1964
Cytogenetic Analysiskidney/monkey25 mg/LECREAL 57,193,1969
Cytogenetic Analysislymphocyte/mammal (species unspecified)500 mg/LMUREAV 81,63,1981
DNA Damage/Bacillus subtilis100 mmol/LBBACAQ 155,476,1968
DNA repair/Escherichia coli500 µg/plateJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae200 ppmJJIND8 62,901,1979
micronucleus testkidney/monkey50 mg/LECREAL 57,193,1969
morphological transformembryo/rat19500 ng/plateJJATDK 1,190,1981
mutation in mammalian somatic cellslymphocyte/mouse31300 µg/LEMMUEG 12(Suppl 13),103,1988
mutation in microorganismslymphocyte/mouse220 mg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms/Schizosaccharomyces pombe1 mole/L (-enzymatic activation step)MUREAV 4,441,1967
mutation in microorganisms/Bacillus subtilis1 mole/L (-enzymatic activation step)MGGEAE 147,1,1976
mutation in microorganisms/Other microorganisms200 mmol/L (-enzymatic activation step)MUREAV 8,451,1969
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)VIRLAX 81,192,1977
mutation in microorganisms/Other microorganisms20 mmol/L (-enzymatic activation step)SCIEAS 148,507,1965
mutation in microorganisms/Other microorganisms450 mmol/L (-enzymatic activation step)MGGEAE 141,207,1975
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)PNASA6 68,3158,1971
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)MUREAV 73,1,1980
mutation in microorganisms/Other microorganisms2 mole/L (-enzymatic activation step)MUREAV 24,245,1974
mutation in microorganisms/Other microorganisms10 mmol/L (-enzymatic activation step)MUREAV 49,163,1978
other mutation test systemsother cell types/human10 mg/LFOBLAN 20,286,1974
other mutation test systemskidney/monkey25 mg/LECREAL 57,193,1969
sister chromatid exchangelymphocyte/mammal (species unspecified)25 mg/LIJEBA6 20,726,1982
sister chromatid exchangelung/hamster5 mmol/LHUGEDQ 54,155,1980
specific locus testoral/Drosophila melanogaster30 mmol/LIJEBA6 17,61,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 11 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgNTIS** AD277-689
oral/mouse lethal dose (50 percent kill): 408 mg/kgAPTOA6 6,285,1950
oral/rat lethal dose (50 percent kill): 141 mg/kgBehavioral: Convulsions or effect on seizure thresholdNTIS** OTS0555279
subcutaneous/Dog lowest published lethal dose: 70 mg/kgHBAMAK 4,1289,1935
subcutaneous/mouse lethal dose (50 percent kill): 125 mg/kgABMGAJ 21,635,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 49500 mg/kg/25W- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thyroid weight
APTOA6 6,285,1950
oral/rat lowest published toxic dose: 2478 mg/kg/6D- continuousBehavioral: Food intake (animal)

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0555279

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 38950; Number of Industries 20; Total Number of Facilities 1258; Number of Occupations 26; Total Number of Employees Exposed 15258; Total Number of Female Employees Exposed 4469
National Occupational Hazard Survey 1974Hazard Code 38950; Number of Industries 18; Total Number of Facilities 1202; Number of Occupations 11; Total Number of Employees Exposed 6578

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; S cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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