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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydroxylamine

RTECS #

NC2975000

CAS #

7803-49-8

Updated

November 2007

Molecular Weight

33.04

Molecular Formula

H3NO

Synonyms

Oxammonium

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/human300 µmol/LMUREAV 4,353,1967
Cytogenetic Analysisleukocyte/human25 mg/LCBINA8 6,375,1973
DNA Damage/Other microorganisms1 mole/LMUREAV 25,235,1974
DNA Damage/Escherichia coli50 mmol/LBBACAQ 119,434,1966
DNA inhibitionlymphocyte/human360 µmol/LTXAPA9 33,38,1975
DNA inhibitionHeLa cell/human10 mmol/LMUREAV 93,447,1982
DNA repair/Bacillus subtilis23 gm/LMUREAV 16,165,1972
DNA repair/Salmonella typhimurium5 pphAGACBH 4,286,1974
mutation in microorganisms/Escherichia coli5 pph (-enzymatic activation step)AGACBH 4,286,1974
mutation in microorganisms/Bacillus subtilis1 mole/L (-enzymatic activation step)PNASA6 48,1796,1962
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)JOVIAM 7,673,1971
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)MGGEAE 128,359,1974
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)SOGEBZ 6,616,1970
mutation in microorganisms/Other microorganisms250 mmol/plate (-enzymatic activation step)PCJOAU 15,482,1981
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)JCPBAN 58,1005,1961
mutation in microorganisms/Other microorganisms50 mmol/L (-enzymatic activation step)MGGEAE 179,191,1980
mutation in microorganisms/Other microorganisms250 mmol/plate (-enzymatic activation step)BZARAZ 32,1146,1979
mutation in microorganisms/Haemophilus influenzae140 mmol/L/5M (-enzymatic activation step)MUREAV 30,9,1975
mutation in microorganisms/Other microorganisms250 mmol/L (-enzymatic activation step)IJEBA6 15,1068,1977
mutation in microorganisms/Other microorganisms250 mmol/L/20M (-enzymatic activation step)MUREAV 7,19,1969
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)JMOBAK 9,352,1964
mutation in microorganisms/Other microorganisms1 mg/L (-enzymatic activation step)MUREAV 74,113,1980
mutation in microorganisms/Other microorganisms20 mmol/L (-enzymatic activation step)SCIEAS 148,507,1965
mutation in microorganisms/Other microorganisms400 mmol/L (-enzymatic activation step)MUREAV 22,223,1974
mutation in microorganisms/Other microorganisms100 mmol/L (-enzymatic activation step)AVIRA2 16,47,1972
mutation in microorganisms/Other microorganisms10 mmol/L (-enzymatic activation step)MUREAV 22,95,1974
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)BBRCA9 39,156,1970
mutation in microorganisms/Salmonella typhimurium5 pph (+enzymatic activation step)AGACBH 4,286,1974
mutation in microorganisms/Neurospora crassa1 mole/L (-enzymatic activation step)MUREAV 12,35,1971
other mutation test systems/Other microorganisms2 mole/LVIRLAX 49,462,1972
phage inhibition capacity/Bacillus subtilis1 mole/LIJEBA6 22,338,1984
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster30 mmol/LMUREAV 16,363,1972
Unscheduled DNA Synthesis/Other microorganisms1 mole/LDBIOAM 217,309,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 60 mg/kgENTOX* -,557,2005
intraperitoneal/rat lethal dose (50 percent kill): 59 mg/kgENTOX* -,557,2005
subcutaneous/rat lethal dose (50 percent kill): 29 mg/kgJPETAB 119,444,1957
unreported route/mouse lethal dose (50 percent kill): 175 mg/kgBJCAAI 6,160,1952

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,557,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84783; Number of Industries 5; Total Number of Facilities 112; Number of Occupations 9; Total Number of Employees Exposed 2689; Total Number of Female Employees Exposed 1481
National Occupational Hazard Survey 1974Hazard Code 84783; Number of Industries 3; Total Number of Facilities 116; Number of Occupations 5; Total Number of Employees Exposed 1722

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; S pombe-forward mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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