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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydroperoxide, alpha,alpha-dimethylbenzyl-

RTECS #

MX2450000

CAS #

80-15-9

Updated

April 2013

Molecular Weight

152.21

Molecular Formula

C9H12O2

Synonyms

7-Hydroperoxykumen (Czech)
alpha,alpha-Dimethylbenzyl hydroperoxide
alpha-Cumyl hydroperoxide
CHP
Cumeenhydroperoxyde (Dutch)
Cumene hydroperoxide
Cumenyl hydroperoxide
Cumolhydroperoxid (German)
Cumyl hydroperoxide
Hydroperoxyde de cumene (French)
Hydroperoxyde de cumyle (French)
Idroperossido di cumene (Italian)
Idroperossido di cumolo (Italian)
Isopropylbenzene hydroperoxide
Kumenylhydroperoxid (Czech)
RCRA waste number U096

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mgAIHAAP 19,205,1958
eye /rabbit 70%VCVGK* -,533,1994
skin /rabbit 500 mgAIHAAP 19,205,1958
skin /rabbit 500 mg mildSCCUR* -,3,1961

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagesperm/other fish20 µmol/L/2HFCTOD7 39,1205,2001
DNA Damagelymphocyte/human15 µmol/L/48HMUREAV 611,1,2006
DNA Damageskin/mouse100 mg/kgMUTAEX 19,499,2004
DNA Damageother cell types/mouse3.8 µmol/L/4HMUREAV 678,123,2009
Dominant Lethal Testintraperitoneal/mouse750 µmol/kg/5D-continuousMUREAV 444,145,1999
gene conversion and mitotic recombination/Saccharomyes cerevisiae47 mg/LMUREAV 308,159,1994
micronucleus testother cell types/mouse4.5 µmol/L/4HMUREAV 678,123,2009
mutation in microorganisms/Salmonella typhimurium100 µg/plate (+enzymatic activation step)PNASA6 79,7445,1982
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)ABCHA6 44,1989,1980
mutation in microorganisms/Escherichia coli12500 ng/plate (-enzymatic activation step)MUREAV 467,41,2000
mutation in microorganisms/Escherichia coli40 µg/plate/20MMUREAV 492,91,2001
mutation in microorganisms/Salmonella typhimurium100 µg/plate/48HMUREAV 540,1,2003
mutation in microorganisms/Salmonella typhimurium33 µg/plate/72H (-enzymatic activation step)MUTAEX 15,495,2000
mutation in microorganisms/Salmonella typhimurium100 µg/plate/48H (-enzymatic activation step)RTOPDW 35,255,2002
mutation in microorganisms/Escherichia coli10 µg/plate/48HMUTAEX 15,317,2000
mutation in microorganisms/Salmonella typhimurium16 mg/L/2H (-enzymatic activation step)MUREAV 578,210,2005
mutation in microorganisms/Salmonella typhimurium160 mg/L/2H (+enzymatic activation step)MUREAV 578,210,2005
mutation in microorganisms/Salmonella typhimurium50 µg/plate/44HFCTOD7 40,105,2002
other mutation test systems/Escherichia coli10 µmol/LMUREAV 203,81,1988
specific locus testother cell types/mouse7.1 µmol/L/4HMUREAV 678,123,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 18000 µg/kg/18W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
ARTODN 78,139,2004
subcutaneous/mouse lowest published toxic dose: 8844 mg/kg/67W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 37,825,1966
unreported route/mouse lowest published toxic dose: 304 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
RARSAM 3,193,1963

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, glioma Inhibitor Concentration (50 percent kill): 44.8 µmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisFCTOD7 49,2398,2011
In Vitro/Rat, glioma Inhibitor Concentration (50 percent kill): 223 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 49,2398,2011
In Vitro/Rat, glioma Inhibitor Concentration Low: 100 µmol/L/24HBiochemical: Metabolism (intermediary): Lipids including transportFCTOD7 49,2398,2011
inhalation/human lowest published toxic concentration: 0.02 mg/m3Eye: Other eye effectsVCVGK* -,532,1994
inhalation/mouse lowest published toxic concentration: 100 mg/m3/2HOlfaction: Other olfaction effects

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,532,1994
inhalation/mouse lowest published toxic concentration: 55 mg/m3/2HBlood: Changes in leukocyte (WBC) countVCVGK* -,532,1994
inhalation/mouse lethal concentration (50 percent kill): 200 ppm/4HLung, Thorax, or Respiration: DyspneaAIHAAP 19,205,1958
inhalation/rat lethal concentration (50 percent kill): 220 ppm/4HLung, Thorax, or Respiration: DyspneaAIHAAP 19,205,1958
intraperitoneal/mouse lethal dose (50 percent kill): 270 mg/kgVCVGK* -,532,1994
intraperitoneal/rat lethal dose (50 percent kill): 235 mg/kgBehavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
VCVGK* -,532,1994
intraperitoneal/rat lethal dose (50 percent kill): 95 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia
AIHAAP 19,205,1958
oral/mouse lowest published lethal dose: 5 gm/kgSCCUR* -,3,1961
oral/mouse lethal dose (50 percent kill): 342 mg/kgVCVGK* -,531,1994
oral/rat lethal dose (50 percent kill): 800 mg/kgVCVGK* -,531,1994
oral/rat lethal dose (50 percent kill): 382 mg/kgKidney, Ureter, and Bladder: HematuriaAIHAAP 19,205,1958
skin/mouse lethal dose (50 percent kill): 490 mg/kgVCVGK* -,532,1994
skin/mouse lowest published toxic dose: 1200 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JOETD7 85,33,2003
skin/mouse lowest published toxic dose: 300 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationMUTAEX 19,499,2004
skin/rabbit lowest published lethal dose: 1200 mg/kgCardiac: Pulse rate increased without fall in BP

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 8(8),12,1964
skin/rat lowest published toxic dose: 250 mg/kgVascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 90,37,2006
skin/rat lethal dose (50 percent kill): 500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria
AEHLAU 30,1,1975
subcutaneous/mouse lethal dose (50 percent kill): 490 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
GISAAA 26(12),22,1961
subcutaneous/rat lethal dose (50 percent kill): 382 mg/kg85JCAE -,242,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 50 ppm/4H/3D- intermittentLung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
intraperitoneal/rat lowest published toxic dose: 399 mg/kg/7W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAIHAAP 19,205,1958
oral/rat lowest published toxic dose: 1604 mg/kg/7W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldAIHAAP 19,205,1958
skin/mouse lowest published toxic dose: 2012 mg/kg/2W- intermittentSkin and Appendages: Tumors

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,338,2004
skin/mouse lowest published toxic dose: 20.1 gm/kg/20W- intermittentSkin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 78,338,2004
skin/mouse lowest published toxic dose: 30442 µg/kg/4W- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationCRNGDP 25,431,2004

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJPHSC* 109,14,2009
TOXICOLOGY REVIEWMUTAEX 26,199,2011
TOXICOLOGY REVIEWMUREAV 678,152,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1346; Number of Industries 125; Total Number of Facilities 10989; Number of Occupations 85; Total Number of Employees Exposed 234305; Total Number of Female Employees Exposed 69933
National Occupational Hazard Survey 1974Hazard Code A1346; Number of Industries 80; Total Number of Facilities 4311; Number of Occupations 53; Total Number of Employees Exposed 95676

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
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