CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Hydroperoxide, alpha,alpha - dimethylbenzyl -

RTECS #: MX2450000

CAS #: 80-15-9


UPDATE: February 2009 MW: 152.21 MF: C9H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 7 - Hydroperoxykumen (Czech)
  2. CHP
  3. Cumeenhydroperoxyde (Dutch)
  4. Cumene hydroperoxide
  5. Cumenyl hydroperoxide
  6. Cumolhydroperoxid (German)
  7. Cumyl hydroperoxide
  8. Hydroperoxyde de cumene (French)
  1. Hydroperoxyde de cumyle (French)
  2. Idroperossido di cumene (Italian)
  3. Idroperossido di cumolo (Italian)
  4. Isopropylbenzene hydroperoxide
  5. Kumenylhydroperoxid (Czech)
  6. RCRA waste number U096
  7. alpha,alpha - Dimethylbenzyl hydroperoxide
  8. alpha - Cumyl hydroperoxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
1 mg N/R AIHAAP 19,205,1958
eye
rabbit
70 % VCVGK* -,533,1994
skin
rabbit
500 mg % AIHAAP 19,205,1958
skin
rabbit
500 mg mild SCCUR* -,3,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
dominant lethal test intraperitoneal
mouse
750 mol/kg/5 day- continuous MUREAV 444,145,1999
DNA damage human lymphocyte 15 mol/L/48 hour MUREAV 611,1,2006
DNA damage skin
mouse
100 mg/kg MUTAEX 19,499,2004
DNA damage other fish sperm 20 mol/L/2 hour FCTOD7 39,1205,2001
mutation in microorganisms Escherichia coli 12,500 ng/plate (-enzymatic activation step) MUREAV 467,41,2000
mutation in microorganisms Escherichia coli 40 g/plate/20 minute MUREAV 492,91,2001
mutation in microorganisms Escherichia coli 10 g/plate/48 hour MUTAEX 15,317,2000
mutation in microorganisms Salmonella typhimurium 100 g/plate (+enzymatic activation step) PNASA6 79,7445,1982
mutation in microorganisms Salmonella typhimurium 100 g/plate (-enzymatic activation step) ABCHA6 44,1989,1980
mutation in microorganisms Salmonella typhimurium 50 g/plate/44 hour FCTOD7 40,105,2002
mutation in microorganisms Salmonella typhimurium 100 g/plate/48 hour MUREAV 540,1,2003
mutation in microorganisms Salmonella typhimurium 33 g/plate/72 hour (-enzymatic activation step) MUTAEX 15,495,2000
mutation in microorganisms Salmonella typhimurium 100 g/plate/48 hour (-enzymatic activation step) RTOPDW 35,255,2002
mutation in microorganisms Salmonella typhimurium 16 mg/L/2 hour (-enzymatic activation step) MUREAV 578,210,2005
mutation in microorganisms Salmonella typhimurium 160 mg/L/2 hour (+enzymatic activation step) MUREAV 578,210,2005
gene conversion and mitotic recombination Saccharomyes cerevisiae 47 mg/L MUREAV 308,159,1994
other mutation test systems Escherichia coli 10 mol/L MUREAV 203,81,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 8,844 mg/kg/67 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 37,825,1966
skin
mouse
lowest published toxic dose: 18,000 g/kg/18 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
ARTODN 78,139,2004
unreported route
mouse
lowest published toxic dose: 304 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors
RARSAM 3,193,1963


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 0.2 mg/m3 Eye: Other eye effects VCVGK* -,532,1994
inhalation
mouse
lethal concentration (50 percent kill): 200 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
inhalation
mouse
lowest published toxic concentration: 100 mg/m3/2 hour Olfaction: Other olfaction effects

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,532,1994
inhalation
mouse
lowest published toxic concentration: 55 mg/m3/2 hour Blood: Changes in leukocyte (WBC) count VCVGK* -,532,1994
inhalation
rat
lethal concentration (50 percent kill): 220 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 19,205,1958
intraperitoneal
mouse
lethal dose (50 percent kill): 270 mg/kg N/R VCVGK* -,532,1994
intraperitoneal
rat
lethal dose (50 percent kill): 95 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia
AIHAAP 19,205,1958
intraperitoneal
rat
lethal dose (50 percent kill): 235 mg/kg Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
VCVGK* -,532,1994
oral
mouse
lowest published lethal dose: 5 gm/kg N/R SCCUR* -,3,1961
oral
mouse
lethal dose (50 percent kill): 342 mg/kg N/R VCVGK* -,531,1994
oral
rat
lethal dose (50 percent kill): 382 mg/kg Kidney, Ureter, and Bladder: Hematuria AIHAAP 19,205,1958
oral
rat
lethal dose (50 percent kill): 800 mg/kg N/R VCVGK* -,531,1994
subcutaneous
mouse
lethal dose (50 percent kill): 490 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
GISAAA 26(12),22,1961
subcutaneous
rat
lethal dose (50 percent kill): 382 mg/kg N/R 85JCAE -,242,1986
skin
mouse
lethal dose (50 percent kill): 490 mg/kg N/R VCVGK* -,532,1994
skin
mouse
lowest published toxic dose: 1,200 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
JOETD7 85,33,2003
skin
rat
lethal dose (50 percent kill): 500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria
AEHLAU 30,1,1975
skin
rat
lowest published toxic dose: 250 mg/kg Vascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 90,37,2006
skin
rabbit
lowest published lethal dose: 1,200 mg/kg Cardiac: Pulse rate increased without fall in BP

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 8(8),12,1964


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 50 ppm/4 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
intraperitoneal
rat
lowest published toxic dose: 399 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958
oral
rat
lowest published toxic dose: 1,604 mg/kg/7 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 19,205,1958
skin
mouse
lowest published toxic dose: 2,012 mg/kg/2 week- intermittent Skin and Appendages: Tumors

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 78,338,2004
skin
mouse
lowest published toxic dose: 20.1 gm/kg/20 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 78,338,2004
skin
mouse
lowest published toxic dose: 30,442 g/kg/4 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation CRNGDP 25,431,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1346;
Number of Industries 80;
Total Number of Facilities 4,311;
Number of Occupations 53;
Total Number of Employees Exposed 95,676
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1346;
Number of Industries 125;
Total Number of Facilities 10,989;
Number of Occupations 85;
Total Number of Employees Exposed 234,305;
Total Number of Female Employees Exposed 69,933


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued.
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us