RTECS:MW3850000 The Registry of Toxic Effects of Chemical Substances

Hydrobromic acid

RTECS #: MW3850000

CAS #: 10035-10-6

UPDATE: May 2009 MW: 80.92 MF: BrH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Acide bromhydrique (French)

Acido bromidrico (Italian)

Anhydrous hydrobromic acid

Bromowodor (Polish)

Bromwasserstoff (German)

Broomwaterstof (Dutch)

Hydrogen bromide

Hydrogen bromide (ACGIH:OSHA)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lethal concentration (50 percent kill): 814 ppm/1 hour N/R ENTOX* -,537,2005
inhalation
rat lowest published toxic concentration: 26 mg/m³ Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Dyspnea VCVN5* -,393,1989
inhalation
rat lethal concentration (50 percent kill): 3,000 ppm/30 minute N/R ENTOX* -,639,2005
inhalation
rat lethal concentration (50 percent kill): 2,858 ppm/1 hour N/R ENTOX* -,537,2005
inhalation
rat lowest published toxic concentration: 10 mg/m³/4 hour Lung, Thorax, or Respiration: Other changes TPKVAL 14,73,1975
intraperitoneal
rat lethal dose (50 percent kill): 76 mg/kg N/R GISAAA 41(1),105,1976

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 2 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,639,2005
TOXICOLOGY REVIEW
ENTOX* -,537,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3 ppm (10 mg/m³) DTLVS* 3,128,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3 ppm (10 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3 ppm (10 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3 ppm (10 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3 ppm (10 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA ceiling concentration 3 ppm (9.9 mg/m³), JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 2 ppm (6.7 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 2 ppm (6.7 mg/m³), OCT 2002
Occupational Exposure Limit - EC short term exposure limit 2 ppm (6.7 mg/m³), FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 3 ppm (10 mg/m³), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 2 ppm (6.7 mg/m³), FEB2006
Occupational Exposure Limit - GERMANY MAK 6.7 mg/m³ (2 mL/m³), 2005
Occupational Exposure Limit - HUNGARY short term exposure limit 6.7 mg/m³, SEP2000
Occupational Exposure Limit - KOREA ceiling concentration 3 ppm (10 mg/m³), 2006
Occupational Exposure Limit - MEXICO peak 3 ppm (10 mg/m³), 2004
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 3 ppm (9.9 mg/m³), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 3 ppm (10 mg/m³), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 3 ppm (10 mg/m³), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 7 mg/m³, MAC(short term exposure limit) 21 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (3.5 mg/m³), ceiling concentration 2 ppm (7 mg/m³), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (6,7 mg/m³);
KZG- week 2 ppm (6,7 mg/m³), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (17 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 3 ppm (10 mg/m³), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 2 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 2 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDROGEN BROMIDE-air ceiling concentration 3 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 38575;
Number of Industries 13;
Total Number of Facilities 510;
Number of Occupations 12;
Total Number of Employees Exposed 2,643
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 38575;
Number of Industries 23;
Total Number of Facilities 1,103;
Number of Occupations 26;
Total Number of Employees Exposed 20,571;
Total Number of Female Employees Exposed 5,398

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of intermediates for pharmaceuticals, dyes, photographic chemicals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903

REFERENCES:
CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5 "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in the manufacture of intermediates for pharmaceuticals, dyes, photographic chemicals

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SYNONYMS:
Acide bromhydrique (French) Acido bromidrico (Italian) Anhydrous hydrobromic acid Bromowodor (Polish)	Bromwasserstoff (German) Broomwaterstof (Dutch) Hydrogen bromide Hydrogen bromide (ACGIH:OSHA)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mouse	lethal concentration (50 percent kill): 814 ppm/1 hour	N/R	ENTOX* -,537,2005
inhalation rat	lowest published toxic concentration: 26 mg/m³	Olfaction: Change in sensation of smell Lung, Thorax, or Respiration: Dyspnea	VCVN5* -,393,1989
inhalation rat	lethal concentration (50 percent kill): 3,000 ppm/30 minute	N/R	ENTOX* -,639,2005
inhalation rat	lethal concentration (50 percent kill): 2,858 ppm/1 hour	N/R	ENTOX* -,537,2005
inhalation rat	lowest published toxic concentration: 10 mg/m³/4 hour	Lung, Thorax, or Respiration: Other changes	TPKVAL 14,73,1975
intraperitoneal rat	lethal dose (50 percent kill): 76 mg/kg	N/R	GISAAA 41(1),105,1976

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	ceiling concentration 2 ppm	DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW		ENTOX* -,639,2005
TOXICOLOGY REVIEW		ENTOX* -,537,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 3 ppm (10 mg/m³)	DTLVS* 3,128,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 3 ppm (10 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8 hour time-weighted average 3 ppm (10 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8 hour time-weighted average 3 ppm (10 mg/m³)	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8 hour time-weighted average 3 ppm (10 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA	ceiling concentration 3 ppm (9.9 mg/m³), JUL2008
Occupational Exposure Limit - BELGIUM	short term exposure limit 2 ppm (6.7 mg/m³), MAR2002
Occupational Exposure Limit - DENMARK	ceiling concentration 2 ppm (6.7 mg/m³), OCT 2002
Occupational Exposure Limit - EC	short term exposure limit 2 ppm (6.7 mg/m³), FEB 2006
Occupational Exposure Limit - FINLAND	short term exposure limit 3 ppm (10 mg/m³), Skin, JAN1999
Occupational Exposure Limit - FRANCE	VLE 2 ppm (6.7 mg/m³), FEB2006
Occupational Exposure Limit - GERMANY	MAK 6.7 mg/m³ (2 mL/m³), 2005
Occupational Exposure Limit - HUNGARY	short term exposure limit 6.7 mg/m³, SEP2000
Occupational Exposure Limit - KOREA	ceiling concentration 3 ppm (10 mg/m³), 2006
Occupational Exposure Limit - MEXICO	peak 3 ppm (10 mg/m³), 2004
Occupational Exposure Limit - NEW ZEALAND	ceiling concentration 3 ppm (9.9 mg/m³), JAN2002
Occupational Exposure Limit - NORWAY	time-weighted average 3 ppm (10 mg/m³), JAN1999
Occupational Exposure Limit - THE PHILIPPINES	time-weighted average 3 ppm (10 mg/m³), JAN1993
Occupational Exposure Limit - POLAND	MAC(time-weighted average) 7 mg/m³, MAC(short term exposure limit) 21 mg/m³, JAN1999
Occupational Exposure Limit - RUSSIA	short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit - SWEDEN	time-weighted average 1 ppm (3.5 mg/m³), ceiling concentration 2 ppm (7 mg/m³), JUN2005
Occupational Exposure Limit - SWITZERLAND	MAK- week 2 ppm (6,7 mg/m³); KZG- week 2 ppm (6,7 mg/m³), DEC2006
Occupational Exposure Limit - TURKEY	time-weighted average 5 ppm (17 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM	short term exposure limit 3 ppm (10 mg/m³), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; ceiling concentration 2 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 2 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDROGEN BROMIDE-air	ceiling concentration 3 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: 38575; Number of Industries 13; Total Number of Facilities 510; Number of Occupations 12; Total Number of Employees Exposed 2,643
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: 38575; Number of Industries 23; Total Number of Facilities 1,103; Number of Occupations 26; Total Number of Employees Exposed 20,571; Total Number of Female Employees Exposed 5,398

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of intermediates for pharmaceuticals, dyes, photographic chemicals
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903

REFERENCES:
CODEN	REFERENCE
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA	Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5*	"Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.