Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Hydrazobenzene

RTECS #

MW2625000

CAS #

122-66-7

Updated

July 2013

Molecular Weight

184.26

Molecular Formula

C12H12N2

Synonyms

(sym)-Diphenylhydrazine
1,2-Diphenylhydrazine
1,2-Diphenylhydrazine (9CI)
Benzene, hydrazodi-
Hydrazine, 1,2-diphenyl-
Hydrazobenzen (Czech)
N,N'-Bianiline
N,N'-Diphenylhydrazine
NCI-C01854
RCRA waste number U109

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster14 mg/LEMMUEG 10(Suppl 10),1,1987
DNA Damageintraperitoneal/mouse75 mg/kgMUREAV 493,39,2001
DNA Damageoral/mouse150 mg/kgMUREAV 493,39,2001
DNA inhibitionintraperitoneal/mouse100 mg/kgMUREAV 46,305,1977
mutation in microorganisms/Salmonella typhimurium10 ng/plate (-enzymatic activation step)ENMUDM 7(Suppl 5),1,1985
sister chromatid exchangeovary/hamster5 mg/LEMMUEG 10(Suppl 10),1,1987
specific locus testother cell types/human157.2 mg/L/3H (+enzymatic activation step)MUTAEX 24,35,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 26 gm/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-92,1978
oral/rat lowest published toxic dose: 2620 mg/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
NCITR* NCI-TR-92,1978
oral/rat toxic dose: 9820 mg/kg/78W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
NCITR* NCI-TR-92,1978
oral/rat toxic dose: 36 gm/kg/53W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
VOONAW 20(4),53,1974
skin/mouse lowest published toxic dose: 5280 mg/kg/26W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
VOONAW 20(4),53,1974
subcutaneous/mouse lowest published toxic dose: 8400 mg/kg/38W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application
VOONAW 20(4),53,1974
subcutaneous/rat lowest published toxic dose: 5200 mg/kg/52W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
GTPZAB 19(6),28,1975
subcutaneous/rat toxic dose: 16 gm/kg/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Ear: Tumors
CANCAR 3,789,1950
subcutaneous/rat toxic dose: 6 gm/kg/27W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
VOONAW 20(4),53,1974

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,75,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-SWITZERLANDcarc 2, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5870; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 977; Total Number of Female Employees Exposed 154

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180356/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-92,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
On EPA IRIS database
TOP