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Registry of Toxic Effects of Chemical Substances (RTECS)

Hydracrylonitrile

RTECS #

MU5250000

CAS #

109-78-4

Updated

February 2006

Molecular Weight

71.09

Molecular Formula

C3H5NO

Synonyms

2-Cyanoethanol
2-Cyanoethyl alcohol
2-Hydroxyethylkyanid (Czech)
3-Hydroxypropanenitrile
3-Hydroxypropionitrile
Aethylencyanhydrin (German)
beta-Hpn
beta-Hydroxypropionitrile
Ethylene cyanohydrin
Glycol cyanohydrin
Methanolacetonitrile
Propanenitrile, 3-hydroxy-
Propionitrile, 3-hydroxy-
USAF RH-7

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg moderateAJOPAA 29,1363,1946
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944
skin /rabbit 520 mg open irritation test mildUCDS** 8/18/1967

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (33 percent kill): 300 mg/m3/2H85GMAT -,66,1982
intraperitoneal/mouse lethal dose (50 percent kill): 500 mg/kgNTIS** AD277-689
intraperitoneal/rat lethal dose (50 percent kill): 3200 mg/kg38MKAJ 2C,4875,1982
oral/mouse lethal dose (50 percent kill): 1800 mg/kgAMIHBC 8,371,1953
oral/rabbit lowest published lethal dose: 900 mg/kgAMIHBC 8,371,1953
oral/rat lethal dose (50 percent kill): 3200 mg/kg38MKAJ 2C,4875,1982
skin/rabbit lethal dose (50 percent kill): 5 mL/kgUCDS** 8/18/1967

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 8100 mg/kg/90D- continuousBrain and Coverings: Changes in brain weight

Cardiac: Changes in heart weight
JTEHD6 2,31,1976

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code E0469; Number of Industries 1; Total Number of Facilities 4; Number of Occupations 3; Total Number of Employees Exposed 348; Total Number of Female Employees Exposed 30

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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