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Hydracrylonitrile

RTECS #: MU5250000

CAS #: 109-78-4


UPDATE: February 2006 MW: 71.09 MF: C3H5NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Cyanoethanol
  2. 2 - Cyanoethyl alcohol
  3. 2 - Hydroxyethylkyanid (Czech)
  4. 3 - Hydroxypropanenitrile
  5. 3 - Hydroxypropionitrile
  6. Aethylencyanhydrin (German)
  7. Ethylene cyanohydrin
  1. Glycol cyanohydrin
  2. Methanolacetonitrile
  3. Propanenitrile, 3 - hydroxy -
  4. Propionitrile, 3 - hydroxy -
  5. USAF RH - 7
  6. beta - Hpn
  7. beta - Hydroxypropionitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg moderate AJOPAA 29,1363,1946
skin
rabbit
10 mg/24 hour open irritation test moderate JIHTAB 26,269,1944
skin
rabbit
520 mg open irritation test mild UCDS** 8/18/1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (33 percent kill): 300 mg/m3/2 hour N/R 85GMAT -,66,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 500 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat
lethal dose (50 percent kill): 3,200 mg/kg N/R 38MKAJ 2C,4875,1982
oral
mouse
lethal dose (50 percent kill): 1,800 mg/kg N/R AMIHBC 8,371,1953
oral
rat
lethal dose (50 percent kill): 3,200 mg/kg N/R 38MKAJ 2C,4875,1982
oral
rabbit
lowest published lethal dose: 900 mg/kg N/R AMIHBC 8,371,1953
skin
rabbit
lethal dose (50 percent kill): 5 mL/kg N/R UCDS** 8/18/1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 8,100 mg/kg/90 day- continuous Brain and Coverings: Changes in brain weight

Cardiac: Changes in heart weight
JTEHD6 2,31,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: E0469;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 3;
Total Number of Employees Exposed 348;
Total Number of Female Employees Exposed 30


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for some cellulose esters and many inorganic salts
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as a solvent for some cellulose esters and many inorganic salts

RTECS Compound Description:
   Primary Irritant

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