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Registry of Toxic Effects of Chemical Substances (RTECS)

Hexyl alcohol

RTECS #

MQ4025000

CAS #

111-27-3

Updated

July 2011

Molecular Weight

102.20

Molecular Formula

C6H14O

Synonyms

1-Hexanol
1-Hydroxyhexane
Amylcarbinol
Caproyl alcohol
EPAL 6
Hexanol
n-Hexanol
n-Hexyl alcohol
Pentylcarbinol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mLHPV112 -,-,2008
skin /rabbit 410 mg open irritation test mildUCDS** 4/21/1967
skin /rabbit 95%/4H mildHPV112 -,-,2008
skin /rabbit 95%/24H moderateHPV112 -,-,2008
skin /rabbit 12 mL/6D severeHPV112 -,-,2008

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagefibroblast/human0.5 mmol/L/1HTOLED5 147,35,2004

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 10000 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV112 -,-,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: >21.4 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration Low: >23.7 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: >12.6 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Mouse, macrophage Inhibitor Concentration Low: >21.4 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
inhalation/guinea pig lethal concentration (50 percent kill): >1060 ppmHPV112 -,-,2008
inhalation/guinea pig Lethal concentration: >1060 ppm/6HFCTXAV 13,695,1975
inhalation/human lowest published toxic concentration: 270 mg/m3Lung, Thorax, or Respiration: CoughVCVGK* -,111,1984
inhalation/mouse lowest published toxic concentration: 15.8 gm/m3/2HBehavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 5,51,1963
inhalation/mouse Lethal concentration: >1060 ppm/6HFCTXAV 13,695,1975
inhalation/mouse lethal concentration (50 percent kill): >1060 ppmHPV112 -,-,2008
inhalation/rat lethal concentration (50 percent kill): >21000 mg/m3/1HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
HPV112 -,-,2008
inhalation/rat lethal concentration (50 percent kill): >1060 ppmHPV112 -,-,2008
inhalation/rat Lethal dose: >1060 ppm/6HFCTXAV 13,695,1975
intraperitoneal/rat lowest published toxic dose: 170 mg/kgBrain and Coverings: Changes in circulation

Behavioral: Ataxia

Behavioral: Tetany
VCVGK* -,110,1984
intravenous/mouse lethal dose (50 percent kill): 103 mg/kgAIPTAK 135,330,1962
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 5,51,1963
oral/mouse lowest published lethal dose: 0.92 gm/kgBrain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral/mouse lethal dose (50 percent kill): 1950 mg/kgHPV112 -,-,2008
oral/mouse lethal dose (50 percent kill): 4000 mg/kgVascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Gastritis
HPV112 -,-,2008
oral/mouse lethal dose (50 percent kill): 1950 mg/kgBrain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,110,1984
oral/mouse lowest published lethal dose: 1000 mg/kgBrain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,110,1984
oral/rat lethal dose (50 percent kill): 710 mg/kgBrain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,110,1984
oral/rat lethal dose (50 percent kill): 720 mg/kgLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
SAMJAF 43,795,1969
oral/rat lethal dose (50 percent kill): 3131 mg/kgHPV112 -,-,2008
oral/rat lethal dose (50 percent kill): 3210 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Gastritis
HPV112 -,-,2008
oral/rat lethal dose (50 percent kill): 4420 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Gastritis

Liver: Other changes
HPV112 -,-,2008
skin/rabbit lethal dose (50 percent kill): 3100 µL/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 2330 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Ulceration or bleeding from stomach
HPV112 -,-,2008
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 2442 mg/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 118 mg/m3/4H/28W- intermittentLiver: Other changes

Brain and Coverings: Other degenerative changes

Eye: Optic nerve neuropathy
VCVGK* -,111,1994
intraperitoneal/rat lowest published toxic dose: 18450 mg/kg/30W- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerveTXAPA9 46,421,1978
oral/Dog lowest published toxic dose: 91 gm/kg/13W- intermittentBehavioral: Tremor

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555542
oral/Dog lowest published toxic dose: 78000 mg/kg/13W- intermittentBehavioral: Ataxia

Gastrointestinal: Gastritis

Reproductive: Paternal effects: Testes, epididymis, sperm duct
HPV112 -,-,2008
oral/Dog lowest published toxic dose: 100100 mg/kg/13W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Maternal effects: Oogenesis

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV112 -,-,2008
oral/rabbit lowest published toxic dose: 9100 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseHYSAAV 31(1-3),310,1966
oral/rat lowest published toxic dose: 101 gm/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 10,379,1982

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 628,67,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,291,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0244; Number of Industries 23; Total Number of Facilities 1126; Number of Occupations 34; Total Number of Employees Exposed 27055; Total Number of Female Employees Exposed 8574
National Occupational Hazard Survey 1974Hazard Code M0244; Number of Industries 12; Total Number of Facilities 3205; Number of Occupations 22; Total Number of Employees Exposed 20684

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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