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Hexyl alcohol

RTECS #: MQ4025000

CAS #: 111-27-3


UPDATE: February 2008 MW: 102.20 MF: C6H14O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Hexanol
  2. 1 - Hydroxyhexane
  3. Amylcarbinol
  4. Caproyl alcohol
  5. EPAL 6
  1. Hexanol
  2. Pentylcarbinol
  3. n - Hexanol
  4. n - Hexyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
410 mg open irritation test mild UCDS** 4/21/1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human fibroblast 0.5 mmol/L/1 hour TOLED5 147,35,2004


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration : >1,060 ppm/6 hour N/R FCTXAV 13,695,1975
inhalation
human
lowest published toxic concentration: 270 mg/m3 Lung, Thorax, or Respiration: Cough VCVGK* -,111,1984
inhalation
mouse
lethal concentration : >1,060 ppm/6 hour N/R FCTXAV 13,695,1975
inhalation
mouse
lowest published toxic concentration: 15.8 gm/m3/2 hour Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 5,51,1963
inhalation
rat
lethal dose : >1,060 ppm/6 hour N/R FCTXAV 13,695,1975
intraperitoneal
rat
lowest published toxic dose: 170 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Ataxia

Behavioral: Tetany
VCVGK* -,110,1984
intravenous
mouse
lethal dose (50 percent kill): 103 mg/kg N/R AIPTAK 135,330,1962
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 5,51,1963
oral
mouse
lethal dose (50 percent kill): 1,950 mg/kg N/R HYSAAV 31(1-3),310,1966
oral
mouse
lethal dose (50 percent kill): 1,950 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,110,1984
oral
mouse
lowest published lethal dose: 1,000 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,110,1984
oral
mouse
lowest published lethal dose: 0.92 gm/kg Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral
rat
lethal dose (50 percent kill): 720 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
SAMJAF 43,795,1969
oral
rat
lethal dose (50 percent kill): 710 mg/kg Brain and Coverings: Changes in circulation

Behavioral: Tetany

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,110,1984
skin
mouse
lowest published toxic dose: 100 pph/3 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive
TPKVAL 5,51,1963
skin
rabbit
lethal dose (50 percent kill): 3,100 ÁL/kg N/R AMIHBC 4,119,1951
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,51,1963
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 2,442 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 118 mg/m3/4 hour/28 week- intermittent Liver: Other changes

Brain and Coverings: Other degenerative changes

Eye: Optic nerve neuropathy
VCVGK* -,111,1994
intraperitoneal
rat
lowest published toxic dose: 18,450 mg/kg/30 week- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve TXAPA9 46,421,1978
oral
dog
lowest published toxic dose: 91 gm/kg/13 week- intermittent Behavioral: Tremor

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0555542
oral
rat
lowest published toxic dose: 101 gm/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 10,379,1982
oral
rabbit
lowest published toxic dose: 9,100 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase HYSAAV 31(1-3),310,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 628,67,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,291,1998
Occupational Exposure Limit - AUSTRIA MAK 210 mg/m3 (50 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0244;
Number of Industries 12;
Total Number of Facilities 3,205;
Number of Occupations 22;
Total Number of Employees Exposed 20,684
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0244;
Number of Industries 23;
Total Number of Facilities 1,126;
Number of Occupations 34;
Total Number of Employees Exposed 27,055;
Total Number of Female Employees Exposed 8,574


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, plasticizer intermediate, specialty ethoxylate intermediate, defoamer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as solvent, plasticizer intermediate, specialty ethoxylate intermediate, defoamer

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Human Data
   Primary Irritant

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