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Registry of Toxic Effects of Chemical Substances (RTECS)

1-Hexanol, 2-ethyl-, phosphate

RTECS #

MP0770000

CAS #

78-42-2

Updated

December 2011

Molecular Weight

434.72

Molecular Formula

C24H51O4P

Synonyms

2-Ethyl-1-hexanol phosphate
Disflamoll TOF
Flexol TOF
Kronitex TOF
Kronitexreg
NCI-C54751
Phosphoric acid tri(2-ethylhexyl) ester
Phosphoric acid, tris(2-ethylhexyl) ester
TOF
Tri(2-ethylhexyl)phosphate
Triethylhexyl phosphate
Trioctyl phosphate
Tris-(2-ethylhexyl)fosfat (Czech)
Tris(2-ethylhexyl)phosphate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg mildAJOPAA 29,1363,1946
eye /rabbit 0.1 mL moderateHPV341 -,-,2001
skin /rabbit 250 mg moderate34ZIAG -,606,1969
skin /rabbit 250 mgHPV341 -,-,2001

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testother cell types/human1 mmol/L/3HMUREAV 724,7,2011
morphological transformfibroblast/mouse0.1 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 520 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
EVHPAZ 65,271,1986
oral/mouse lowest published toxic dose: 257500 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB85-171502/AS
oral/mouse lowest published toxic dose: 515000 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB85-171502/AS
oral/mouse lowest published toxic dose: 480000 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV341 -,-,2001
oral/rat lowest published toxic dose: 1920000 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV341 -,-,2001
oral/rat lowest published toxic dose: 1030000 mg/kg/103W- intermittentTumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors
NTIS** PB85-171502/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 450 mg/m3/30M85JCAE -,1133,1986
inhalation/guinea pig lethal concentration (50 percent kill): >460 mg/m3/1HHPV341 -,-,2001
inhalation/rat lethal concentration (50 percent kill): >447 mg/m3/4HHPV341 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 3200 mg/kgNTIS** OTS0528341
intraperitoneal/rat lethal dose (50 percent kill): 30 gm/kgNTIS** OTS0528341
intratracheal/rabbit lethal dose (50 percent kill): >1811 mg/kgHPV341 -,-,2001
intravenous/rabbit lethal dose (50 percent kill): >358 mg/kgHPV341 -,-,2001
oral/mammal (species unspecified) lethal dose (50 percent kill): 7600 mg/kgGISAAA 39(4),86,1974
oral/mouse lethal dose (50 percent kill): 12800 mg/kgNTIS** OTS0528341
oral/rabbit lethal dose (50 percent kill): 46000 mg/kgHPV341 -,-,2001
oral/rat lethal dose (50 percent kill): >36800 mg/kgHPV341 -,-,2001
skin/rabbit lethal dose (50 percent kill): 20000 mg/kgHPV341 -,-,2001
unreported route/rat lethal dose (50 percent kill): 40 gm/kg29ZWAE -,337,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 85 mg/m3/90D- continuousBehavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Other changes
HPV341 -,,2001
inhalation/guinea pig lowest published toxic concentration: 9.6 mg/m3/90D- continuousKidney, Ureter, and Bladder: Other changesHPV341 -,,2001
oral/mouse lowest published toxic dose: 260000 mg/kg/13W- continuousGastrointestinal: Gastritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV341 -,,2001
oral/mouse lowest published toxic dose: 32500 mg/kg/13W- intermittentGastrointestinal: Other changesNTPTR* NTP-TR-274,1984
oral/mouse lowest published toxic dose: 10080 mg/kg/14D- continuousBehavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
NTPTR* NTP-TR-274,1984
oral/rat lowest published toxic dose: 130000 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV341 -,,2001
oral/rat lowest published toxic dose: 18900 mg/kg/9W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOLED5 13,29,1982
oral/rat lowest published toxic dose: 4200 mg/kg/14D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-274,1984
oral/rat lowest published toxic dose: 46500 mg/kg/30D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV341 -,,2001
skin/rabbit lowest published toxic dose: 0.5 mL/kg/2W- continuousSkin: After topical application: Primary irritationHPV341 -,,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWFEREAC 72,5621,2007
TOXICOLOGY REVIEWMUREAV 653,99,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80228; Number of Industries 1; Total Number of Facilities 40; Number of Occupations 1; Total Number of Employees Exposed 1209; Total Number of Female Employees Exposed 725
National Occupational Hazard Survey 1974Hazard Code 80228; Number of Industries 6; Total Number of Facilities 108; Number of Occupations 22; Total Number of Employees Exposed 3565

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat
NTP Carcinogenesis Studies (gavage);some evidence:mouse NTPTR* NTP-TR-274,1984
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