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1 - Hexanol, 2 - ethyl -

RTECS #: MP0350000

CAS #: 104-76-7


UPDATE: August 2008 MW: 130.26 MF: C8H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Aethylhexanol (German)
  2. 2 - Ethylhexanol
  3. 2 - Ethyl - 1 - hexanol
  1. 2 - Ethylhexyl alcohol
  2. Ethylhexanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg severe AJOPAA 29,1363,1946
eye
rabbit
20 mg/24 hour moderate 85JCAE -,200,1986
skin
rabbit
415 mg open irritation test mild UCDS** 11/11/1969
skin
rabbit
500 mg/24 hour moderate FCTXAV 17,775,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 Ámol/L (+enzymatic activation step) EVHPAZ 45,111,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 12 gm/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** PB85-220143
oral
mouse
lowest published toxic dose: 12,200 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,29,1987
oral
rat
lowest published toxic dose: 1,628 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 35,41,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
man
lowest published toxic concentration: 10 ppm/4 hour Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Behavioral: Excitement
NRTXDN 28,347,2007
inhalation
mouse
lowest published toxic concentration: 270 mg/m3 Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,115,1984
inhalation
rat
lethal concentration : >2,000 ppm/6 hour N/R KODAK* 21MAY1971
inhalation
rat
lowest published toxic concentration: 210 mg/m3 Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Liver: Other changes
VCVGK* -,115,1984
inhalation
rat
lowest published toxic concentration: 0.85 mg/m3/4 hour N/R FEREAC 70,51623,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 759 mg/kg N/R ZHYGAM 20,575,1974
intraperitoneal
rat
lethal dose (50 percent kill): 500 mg/kg N/R HYDRDA 3,201,1978
oral
guinea pig
lethal dose (50 percent kill): 1,860 mg/kg N/R ZHYGAM 20,575,1974
oral
human
lowest published lethal dose: 428.6 mg/kg N/R VCVGK* -,116,1984
oral
mouse
lethal dose (50 percent kill): 2,500 mg/kg N/R ZHYGAM 20,575,1974
oral
rat
lethal dose (50 percent kill): 3,730 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 34,493,1973
oral
rabbit
lethal dose (50 percent kill): 1,180 mg/kg N/R ZHYGAM 20,575,1974
parenteral
mouse
lethal dose (50 percent kill): 1,670 mg/kg N/R FCTXAV 17,775,1979
parenteral
rat
lethal dose (50 percent kill): 4,600 mg/kg N/R FCTXAV 17,775,1979
subcutaneous
rat
lethal dose (50 percent kill): 650 mg/kg N/R NPIRI* 1,61,1974
skin
rat
lethal dose (50 percent kill): >3 gm/kg N/R NTIS** OTS0524344
skin
rabbit
lethal dose (50 percent kill): 1,970 mg/kg N/R NPIRI* 1,61,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 250 gm/m3/5 day- intermittent Immunological Including Allergic: Decreased immune response

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
TXAPA9 197,280,2004
inhalation
rat
lowest published toxic concentration: 102 mg/m3/4 hour/137 day- intermittent Behavioral: Irritability

Lung, Thorax, or Respiration: Other changes
VCVGK* -,116,1994
inhalation
rat
lowest published toxic concentration: 1.5 mg/m3/90 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,116,1994
oral
mouse
lowest published toxic dose: 9 gm/kg/11 day- intermittent Gastrointestinal: Other changes

Liver: Changes in liver weight
FAATDF 29,31,1996
oral
mouse
lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight
FAATDF 29,31,1996
oral
mouse
lowest published toxic dose: 3,247 mg/kg/17 day- continuous Behavioral: Food intake (animal) NTIS** #PB91-185900
oral
mouse
lowest published toxic dose: 22,500 mg/kg/90 day- intermittent Gastrointestinal: Other changes FEREAC 70,51623,2005
oral
rat
lowest published toxic dose: 2,970 mg/kg/9 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity
NTIS** OTS0540989
oral
rat
lowest published toxic dose: 9 gm/kg/11 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FAATDF 29,31,1996
oral
rat
lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Gastrointestinal: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FAATDF 29,31,1996
oral
rat
lowest published toxic dose: 14 gm/kg/17 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
BCSTB5 2,322,1974
oral
rat
lowest published toxic dose: 25,200 mg/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 10,379,1982
oral
rat
lowest published toxic dose: 260 gm/kg/2 year- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 13,70,1993
oral
rat
lowest published toxic dose: 24.5 gm/kg/14 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ATSUDG 12,274,1988
oral
rat
lowest published toxic dose: 2,100 mg/kg/3 week- continuous Liver: Other changes VCVGK* -,116,1994
oral
rat
lowest published toxic dose: 24,000 mg/kg/60 day- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,116,1994
oral
rat
lowest published toxic dose: 25,380 mg/kg/90 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
FEREAC 70,51623,2005
oral
rat
lowest published toxic dose: 22,500 mg/kg/90 day- intermittent Liver: Other changes

Biochemical: Effect on specific coenzyme: CoA
FEREAC 70,51623,2005
skin
rat
lowest published toxic dose: 7,506 mg/kg/11 day- intermittent Endocrine: Changes in spleen weight

Blood: Changes in other cell count (unspecified)

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0536344


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
TOLED5 140-141,261,2003
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
REPTED 22,291,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - GERMANY MAK 110 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 270 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (110 mg/m3),KZG- week 20 ppm (110 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0262;
Number of Industries 67;
Total Number of Facilities 3,280;
Number of Occupations 62;
Total Number of Employees Exposed 45,342
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0262;
Number of Industries 97;
Total Number of Facilities 11,356;
Number of Occupations 74;
Total Number of Employees Exposed 117,564;
Total Number of Female Employees Exposed 11,656


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as base for many plasticizers and a solvent for resins, waxes, oils and dyes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HYDRDA Hydrometallurgy. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1975-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used as base for many plasticizers and a solvent for resins, waxes, oils and dyes

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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