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Registry of Toxic Effects of Chemical Substances (RTECS)

Hexanoic acid, 2-ethyl-

RTECS #

MO7700000

CAS #

149-57-5

Updated

September 201

Molecular Weight

144.24

Molecular Formula

C8H16O2

Synonyms

2-Butylbutanoic acid
2-Ethylcaproic acid
2-Ethylhexanoic acid
2-Ethylhexanoic-acid
2-Ethylhexoic acid
3-Heptanecarboxylic acid
alpha-Ethylcaproic acid
Butylethylacetic acid
Kyselina 2-ethylkapronova (Czech)
Kyselina heptan-3-karboxylova (Czech)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944
skin /rabbit 450 mg open irritation test mildUCDS** 11/4/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sister chromatid exchangelymphocyte/human630 µmol/LMUREAV 279,75,1992

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 1803 mg/kg (12D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 35,41,1987
oral/rat 5 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 20,199,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lethal concentration: >400 ppm/6HKODAK* 21MAY1971
inhalation/rat lethal concentration (50 percent kill): >2360 mg/m3/6HHPV287 -,-,2002
oral/rat lethal dose (50 percent kill): 1600 mg/kgHPV287 -,-,2002
skin/guinea pig lethal dose (50 percent kill): 6300 µL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 1260 µL/kgUCDS** 11/4/1971

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 81116 mg/kg/2W- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0525547
oral/mouse lowest published toxic dose: 79650 mg/kg/90D- continuousLiver: Other changes

Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
NTIS** OTS0543763
oral/rat lowest published toxic dose: 27.2 gm/kg/14D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
ATSUDG 12,274,1988
oral/rat lowest published toxic dose: 25200 mg/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 10,379,1982
oral/rat lowest published toxic dose: 8800 mg/kg/2W- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Skin and Appendages: Other: Hair
NTIS** OTS0525547
oral/rat lowest published toxic dose: 82530 mg/kg/90D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0543763

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWIJTOFN 24,1,2005
TOXICOLOGY REVIEWMUREAV 750,141,2012
TOXICOLOGY REVIEWMUREAV 750,141,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3 (vapor, aerosol), MAR2002

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84204; Number of Industries 135; Total Number of Facilities 15863; Number of Occupations 89; Total Number of Employees Exposed 176189; Total Number of Female Employees Exposed 20117
National Occupational Hazard Survey 1974Hazard Code 84204; Number of Industries 23; Total Number of Facilities 711; Number of Occupations 28; Total Number of Employees Exposed 15851

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0593-9057
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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