CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Hexanoic acid

RTECS #: MO5250000

CAS #: 142-62-1


UPDATE: February 2006 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Butylacetic acid
  2. Capronic acid
  3. Hexacid 698
  4. Kyselina kapronova (Czech)
  5. Pentanecarboxylic acid
  1. Pentiformic acid
  2. Pentylformic acid
  3. n - Caproic acid
  4. n - Hexanoic acid
  5. n - Hexoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
750 g severe AJOPAA 29,1363,1946
skin
rabbit
10 mg/24 hour open irritation test mild AMIHBC 10,61,1954
skin
rabbit
465 mg open irritation test mild UCDS** 11/2/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis non-mammalian species other cell types 10 mmol/L CHROAU 40,1,1973
other mutation test systems non-mammalian species other cell types 10 mmol/L CHROAU 40,1,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 4,100 mg/m3/2 hour N/R 85GMAT -,32,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
intravenous
mouse
lethal dose (50 percent kill): 1,725 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
APTOA6 18,141,1961
oral
mouse
lethal dose (50 percent kill): 5 gm/kg N/R 85GMAT -,32,1982
oral
rat
lethal dose (50 percent kill): 2,050 L/kg N/R UCDS** 11/2/1971
oral
rat
lethal dose (50 percent kill): 3 gm/kg N/R USXXAM #6696575
subcutaneous
mouse
lethal dose (50 percent kill): 3,180 mg/kg N/R JPPMAB 21,85,1969
skin
guinea pig
lethal dose (50 percent kill): 5 mL/kg N/R JIHTAB 26,269,1944
skin
rabbit
lethal dose (50 percent kill): 630 L/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 25,200 mg/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 10,379,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84192;
Number of Industries 3;
Total Number of Facilities 60;
Number of Occupations 7;
Total Number of Employees Exposed 1,526
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84192;
Number of Industries 8;
Total Number of Facilities 735;
Number of Occupations 14;
Total Number of Employees Exposed 10,060;
Total Number of Female Employees Exposed 3,562


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of esters for artificial flavors and of hexyl derivatives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used in the manufacture of esters for artificial flavors and of hexyl derivatives

RTECS Compound Description:
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us