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Registry of Toxic Effects of Chemical Substances (RTECS)

Hexanoic acid

RTECS #

MO5250000

CAS #

142-62-1

Updated

February 2006

Molecular Weight

116.18

Molecular Formula

C6H12O2

Synonyms

Butylacetic acid
Capronic acid
Hexacid 698
Kyselina kapronova (Czech)
n-Caproic acid
n-Hexanoic acid
n-Hexoic acid
Pentanecarboxylic acid
Pentiformic acid
Pentylformic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 750 µg severeAJOPAA 29,1363,1946
skin /rabbit 10 mg/24H open irritation test mildAMIHBC 10,61,1954
skin /rabbit 465 mg open irritation test mildUCDS** 11/2/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisother cell types/non-mammalian species10 mmol/LCHROAU 40,1,1973
other mutation test systemsother cell types/non-mammalian species10 mmol/LCHROAU 40,1,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 4100 mg/m3/2H85GMAT -,32,1982
intraperitoneal/mouse lethal dose (50 percent kill): 3180 mg/kgJPPMAB 21,85,1969
intravenous/mouse lethal dose (50 percent kill): 1725 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
APTOA6 18,141,1961
oral/mouse lethal dose (50 percent kill): 5 gm/kg85GMAT -,32,1982
oral/rat lethal dose (50 percent kill): 2050 µL/kgUCDS** 11/2/1971
oral/rat lethal dose (50 percent kill): 3 gm/kgUSXXAM #6696575
skin/guinea pig lethal dose (50 percent kill): 5 mL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 630 µL/kgAMIHBC 10,61,1954
subcutaneous/mouse lethal dose (50 percent kill): 3180 mg/kgJPPMAB 21,85,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 25200 mg/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)TOLED5 10,379,1982

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84192; Number of Industries 8; Total Number of Facilities 735; Number of Occupations 14; Total Number of Employees Exposed 10060; Total Number of Female Employees Exposed 3562
National Occupational Hazard Survey 1974Hazard Code 84192; Number of Industries 3; Total Number of Facilities 60; Number of Occupations 7; Total Number of Employees Exposed 1526

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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