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Registry of Toxic Effects of Chemical Substances (RTECS)

2,5-Hexanediol

RTECS #

MO2275000

CAS #

2935-44-6

Updated

February 2003

Molecular Weight

118.20

Molecular Formula

C6H14O2

Synonyms

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 980 mg/kgBehavioral: AtaxiaVCVGK* -,155,1984
oral/mouse lethal dose (50 percent kill): 4846 mg/kgJAPMA8 45,669,1956
oral/mouse lethal dose (50 percent kill): 2400 mg/kgGastrointestinal: Other changesVCVGK* -,155,1984
oral/rat lethal dose (50 percent kill): 5000 mg/kgGastrointestinal: Other changesVCVGK* -,155,1984
oral/rat lethal dose (50 percent kill): 2 gm/kgJAFCAU 23,418,1975
skin/rabbit lethal dose (50 percent kill): 16300 µL/kgJIHTAB 30,63,1948
subcutaneous/rabbit lethal dose (50 percent kill): 16000 mg/kgGastrointestinal: Other changesVCVGK* -,155,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/chicken lowest published toxic dose: 3000 mg/kg/30D- intermittentPeripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Ataxia
VCVGK* -,155,1994
intraperitoneal/chicken lowest published toxic dose: 18 gm/kg/90D- intermittentSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TXAPA9 62,369,1982
oral/chicken lowest published toxic dose: 3000 mg/kg/30D- intermittentPeripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Ataxia
VCVGK* -,155,1994
oral/chicken lowest published toxic dose: 9 gm/kg/90D- intermittentSpinal Cord: Demyelination

Spinal Cord: Other degenerative changes

Behavioral: Ataxia
TXAPA9 62,369,1982
oral/mouse lowest published toxic dose: 22423 mg/kg/7D- intermittentEndocrine: Changes in adrenal weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
ENVRAL 36,14,1985
oral/rat lowest published toxic dose: 29400 mg/kg/11W- intermittentAutonomic Nervous System: Other (direct) parasympathomimeticEESADV 3,204,1979
oral/rat lowest published toxic dose: 35 gm/kg/5W- continuousEye: Retinal changes pigmentary deposition, retinitis, other)

Autonomic Nervous System: Other (direct) parasympathomimetic
ARTODN 67,277,1993
oral/rat lowest published toxic dose: 7 gm/kg/7D- intermittentEndocrine: Other changes

Endocrine: Changes in thymus weight
IJEBA6 24,371,1986
oral/rat lowest published toxic dose: 24400 mg/kg/122D- intermittentSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,155,1994
oral/rat lowest published toxic dose: 61.25 mg/kg/7W- continuousSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Eye: Other eye effects
VCVGK* -,155,1994
oral/rat lowest published toxic dose: 61.25 mg/kg/14W- continuousSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness
VCVGK* -,155,1994
oral/rat lowest published toxic dose: 28000 mg/kg/10W- intermittentSpinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness
VCVGK* -,155,1994
oral/rat lowest published toxic dose: 1.75 mg/kg/7D- intermittentEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,155,1994
oral/rat lowest published toxic dose: 6720 mg/kg/7D- intermittentBlood: Changes in cell count (unspecified)

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVGK* -,155,1994

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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