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2,5 - Hexanediol

RTECS #: MO2275000

CAS #: 2935-44-6


UPDATE: February 2003 MW: 118.20 MF: C6H14O2


NOTE:

TABLE OF CONTENTS:
  1. ACUTE TOXICITY DATA:
  2. OTHER MULTIPLE DOSE DATA:
  3. STATUS IN FEDERAL AGENCIES:
  4. REFERENCES:

SYNONYMS:

N/R N/R


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 980 mg/kg Behavioral: Ataxia VCVGK* -,155,1984
oral
mouse
lethal dose (50 percent kill): 4,846 mg/kg N/R JAPMA8 45,669,1956
oral
mouse
lethal dose (50 percent kill): 2,400 mg/kg Gastrointestinal: Other changes VCVGK* -,155,1984
oral
rat
lethal dose (50 percent kill): 2 gm/kg N/R JAFCAU 23,418,1975
oral
rat
lethal dose (50 percent kill): 5,000 mg/kg Gastrointestinal: Other changes VCVGK* -,155,1984
subcutaneous
rabbit
lethal dose (50 percent kill): 16,000 mg/kg Gastrointestinal: Other changes VCVGK* -,155,1984
skin
rabbit
lethal dose (50 percent kill): 16,300 ÁL/kg N/R JIHTAB 30,63,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
chicken
lowest published toxic dose: 18 gm/kg/90 day- intermittent Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Peripheral Nerve and Sensation: Structural change in nerve or sheath
TXAPA9 62,369,1982
intraperitoneal
chicken
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Ataxia
VCVGK* -,155,1994
oral
chicken
lowest published toxic dose: 9 gm/kg/90 day- intermittent Spinal Cord: Demyelination

Spinal Cord: Other degenerative changes

Behavioral: Ataxia
TXAPA9 62,369,1982
oral
chicken
lowest published toxic dose: 3,000 mg/kg/30 day- intermittent Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Behavioral: Ataxia
VCVGK* -,155,1994
oral
mouse
lowest published toxic dose: 22,423 mg/kg/7 day- intermittent Endocrine: Changes in adrenal weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response
ENVRAL 36,14,1985
oral
rat
lowest published toxic dose: 29,400 mg/kg/11 week- intermittent Autonomic Nervous System: Other (direct) parasympathomimetic EESADV 3,204,1979
oral
rat
lowest published toxic dose: 35 gm/kg/5 week- continuous Eye: Retinal changes pigmentary deposition, retinitis, other)

Autonomic Nervous System: Other (direct) parasympathomimetic
ARTODN 67,277,1993
oral
rat
lowest published toxic dose: 7 gm/kg/7 day- intermittent Endocrine: Other changes

Endocrine: Changes in thymus weight
IJEBA6 24,371,1986
oral
rat
lowest published toxic dose: 1.75 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,155,1994
oral
rat
lowest published toxic dose: 6,720 mg/kg/7 day- intermittent Blood: Changes in cell count (unspecified)

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVGK* -,155,1994
oral
rat
lowest published toxic dose: 24,400 mg/kg/122 day- intermittent Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,155,1994
oral
rat
lowest published toxic dose: 61.25 mg/kg/7 week- continuous Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Eye: Other eye effects
VCVGK* -,155,1994
oral
rat
lowest published toxic dose: 61.25 mg/kg/14 week- continuous Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness
VCVGK* -,155,1994
oral
rat
lowest published toxic dose: 28,000 mg/kg/10 week- intermittent Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Muscle weakness
VCVGK* -,155,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (GLYCOLS), SRC, 2/82

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