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1,6 - Hexanediol

RTECS #: MO2100000

CAS #: 629-11-8


UPDATE: August 2006 MW: 118.20 MF: C6H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,6 - Dihydroxyhexane
  2. HDO
  3. Hexamethylenediol
  1. Hexamethylene glycol
  2. alpha,omega - Hexanediol
  3. omega - Hexanediol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg N/R IHFCAY 6,1,1967
eye
rabbit
500 mg/24 hour mild 85JCAE -,210,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,210,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 1,738 mg/kg N/R TXAPA9 49,385,1979
intraperitoneal
rat
lowest published toxic dose: 1,350 mg/kg Behavioral: Ataxia VCVGK* -,155,1984
oral
mouse
lethal dose (50 percent kill): 2,400 mg/kg Gastrointestinal: Other changes VCVGK* -,155,1984
oral
rat
lethal dose (50 percent kill): 3,730 mg/kg N/R TXAPA9 28,313,1974
oral
rat
lethal dose (50 percent kill): 3,700 mg/kg Gastrointestinal: Other changes VCVGK* -,155,1984
skin
rabbit
lethal dose (50 percent kill): >10 gm/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 10,764 mg/kg/26 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NRTXDN 26,229,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83598;
Number of Industries 2;
Total Number of Facilities 36;
Number of Occupations 6;
Total Number of Employees Exposed 1,740
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83598;
Number of Industries 3;
Total Number of Facilities 59;
Number of Occupations 11;
Total Number of Employees Exposed 3,529;
Total Number of Female Employees Exposed 313


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a high-performance diol for rigid urethanes and high-solid coatings
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological Series, Bulletin. (Pittsburgh, PA) 1947-69.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a high-performance diol for rigid urethanes and high-solid coatings

NIOSH PROFILE (GLYCOLS), SRC, 2/82

RTECS Compound Description:
   Primary Irritant

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