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Registry of Toxic Effects of Chemical Substances (RTECS)

1,6-Hexanediamine

RTECS #

MO1180000

CAS #

124-09-4

Updated

September 201

Molecular Weight

116.24

Molecular Formula

C6H16N2

Synonyms

1,6-Diaminohexane
1,6-Hexamethylenediamine
1,6-Hexanediamine (ACGIH)
Hexamethylenediamine
HMDA
NCI-C61405

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mL severeHPV113 -,-,2001
skin /rabbit 85%/15MDCTODJ 44,15,2005
skin /rabbit 6%DCTODJ 44,15,2005
skin /rabbit 50%/12D- intermittentDCTODJ 44,15,2005
skin /rat 1%DCTODJ 44,15,2005
skin /rat 1%/3W- intermittentDCTODJ 44,15,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 414 mg/kg (10D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 28,237,1983
intraperitoneal/mouse 2060 mg/kg (10-14D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
DCTODJ 28,15,2005
oral/rat 1840 mg/kg (7-16D pregnant)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV114 -,-,2003
oral/rat 3000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)DCTODJ 28,15,2005
oral/rat 184 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemDCTODJ 28,15,2005
oral/rat 3 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
JJATDK 7,259,1987
oral/rat 1840 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemJJATDK 7,259,1987
oral/rat 77 gm/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FAATDF 16,490,1991
oral/rat 66500 mg/kg (multigeneration)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)FAATDF 16,490,1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/rabbit lowest published toxic dose: 85 pphEye: Lacrimation

Eye: Conjunctiva irritation
DCTODJ 44,15,2005
inhalation/mouse Lowest published lethal concentration: 750 mg/m3/10MDCTODJ 44,15,2005
inhalation/rat lethal concentration (50 percent kill): >950 mg/m3/4HHPV114 -,-,2003
inhalation/rat Lethal concentration: >950 mg/m3/4HEPASR* 8EHQ-1090-0979
intraperitoneal/mouse lethal dose (50 percent kill): 320 mg/kgDCTODJ 44,15,2005
intraperitoneal/rat lethal dose (50 percent kill): 320 mg/kgDCTODJ 44,15,2005
intravenous/mouse lethal dose (50 percent kill): 180 mg/kgDCTODJ 44,15,2005
oral/mouse lethal dose (50 percent kill): 380 mg/kgDCTODJ 44,15,2005
oral/rat lethal dose (50 percent kill): 750 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
oral/rat lethal dose (50 percent kill): 750 mg/kgTXAPA9 42,417,1977
oral/rat lethal dose (50 percent kill): 792 mg/kgGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV114 -,-,2003
skin/guinea pig lowest published toxic dose: 100 µL/kg/1HSkin: After topical application: Primary irritationDCTODJ 44,15,2005
skin/rabbit lethal dose (50 percent kill): 1110 mg/kgHPV114 -,-,2003
subcutaneous/mouse lethal dose (50 percent kill): 1300 mg/kgDCTODJ 44,15,2005
subcutaneous/rat lowest published toxic dose: 96 mg/kgSkin: After systemic exposure: Dermatitis, otherDCTODJ 44,15,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 50 ppm/3D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea
DCTODJ 44,15,2005
inhalation/guinea pig lowest published toxic concentration: 50 ppm/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldDCTODJ 44,15,2005
inhalation/mouse lowest published toxic concentration: 800 mg/m3/16D- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
DCTODJ 44,15,2005
inhalation/mouse lowest published toxic concentration: 800 mg/m3/16D- intermittentGastrointestinal: Changes in structure or function of exocrine pancreas

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
inhalation/mouse lowest published toxic concentration: 800 mg/m3/16D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductDCTODJ 44,15,2005
inhalation/mouse lowest published toxic concentration: 800 mg/m3/16D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesDCTODJ 44,15,2005
inhalation/mouse lowest published toxic concentration: 267 mg/m3/16D- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 2100 ppm/2D- intermittentOlfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 2100 ppm/2D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 2100 ppm/2D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldDCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 1050 ppm/11D- intermittentOlfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 1050 ppm/11D- intermittentBehavioral: Sleep

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 1050 ppm/11D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldDCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 51 mg/m3/13W- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 215 mg/m3/13W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 50 mg/m3/13W- intermittentOlfaction: Other olfaction effects

Ear: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 1 mg/m3/90D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainDCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 800 mg/m3/16D- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 800 mg/m3/16D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldDCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 267 mg/m3/16D- intermittentOlfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects

Eye: Other eye effects
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 267 mg/m3/16D- intermittentLung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 267 mg/m3/16D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubesDCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 49 mg/m3/4W- intermittentEye: Ptosis

Behavioral: Somnolence (general depressed activity)
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 262 mg/m3/4W- intermittentOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 5000 mg/m3/3W- intermittentLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
inhalation/rat lowest published toxic concentration: 5 gm/m3/6H/2W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
inhalation/rat lowest published toxic concentration: 215 mg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 9,504,1987
inhalation/rat lowest published toxic concentration: 360 µg/m3/17W- intermittentCardiac: Other changes

Vascular: Other changes
GISAAA 23(11),71,1958
inhalation/rat lowest published toxic concentration: 215 mg/m3/13W- intermittentLung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV114 -,-,2003
oral/guinea pig lowest published toxic dose: 400 mg/kg/20D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
DCTODJ 44,15,2005
oral/guinea pig lowest published toxic dose: 400 mg/kg/20D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainDCTODJ 44,15,2005
oral/rat lowest published toxic dose: 13650 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainDCTODJ 44,15,2005
oral/rat lowest published toxic dose: 4200 mg/kg/2W- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Irritability

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
oral/rat lowest published toxic dose: 4200 mg/kg/2W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldDCTODJ 44,15,2005
oral/rat lowest published toxic dose: 3000 mg/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldDCTODJ 44,15,2005
oral/rat lowest published toxic dose: 2700 mg/kg/6D- intermittentBlood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
oral/rat lowest published toxic dose: 1350 mg/kg/6D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainDCTODJ 44,15,2005
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainDCTODJ 44,15,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWDCTODJ ,15,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.5 ppm (2.3 mg/m3), inhal, skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.5 ppm (2.3 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 ppm (2.3 mg/m3), MAY2011
Occupational Exposure Limit-HUNGARYtime-weighted average 2.3 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 0.5 ppm (2.3 mg/m3), NOV2011
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2.3 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83335; Number of Industries 9; Total Number of Facilities 879; Number of Occupations 24; Total Number of Employees Exposed 31036; Total Number of Female Employees Exposed 4686
National Occupational Hazard Survey 1974Hazard Code 83335; Number of Industries 4; Total Number of Facilities 62; Number of Occupations 9; Total Number of Employees Exposed 1093

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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