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1,6 - Hexanediamine

RTECS #: MO1180000

CAS #: 124-09-4


UPDATE: February 2009 MW: 116.24 MF: C6H16N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,6 - Diaminohexane
  2. 1,6 - Hexamethylenediamine
  3. 1,6 - Hexanediamine (ACGIH)
  1. HMDA
  2. Hexamethylenediamine
  3. NCI - C61405


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 414 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 28,237,1983
intraperitoneal
mouse
lowest published toxic dose: 2,060 mg/kg (10-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
DCTODJ 28,15,2005
oral
rat
lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system
JJATDK 7,259,1987
oral
rat
lowest published toxic dose: 1,840 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JJATDK 7,259,1987
oral
rat
lowest published toxic dose: 77 gm/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 16,490,1991
oral
rat
lowest published toxic dose: 66,500 mg/kg (multigeneration) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) FAATDF 16,490,1991
oral
rat
lowest published toxic dose: 3,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) DCTODJ 28,15,2005
oral
rat
lowest published toxic dose: 184 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system DCTODJ 28,15,2005


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
lowest published toxic dose: 85 pph Eye: Lacrimation

Eye: Conjunctiva irritation
DCTODJ 44,15,2005
inhalation
mouse
lowest published lethal concentration: 750 mg/m3/10 minute N/R DCTODJ 44,15,2005
inhalation
rat
lethal concentration : >950 mg/m3/4 hour N/R EPASR* 8EHQ-1090-0979
intraperitoneal
mouse
lethal dose (50 percent kill): 320 mg/kg N/R DCTODJ 44,15,2005
intraperitoneal
rat
lethal dose (50 percent kill): 320 mg/kg N/R DCTODJ 44,15,2005
intravenous
mouse
lethal dose (50 percent kill): 180 mg/kg N/R DCTODJ 44,15,2005
oral
mouse
lethal dose (50 percent kill): 380 mg/kg N/R DCTODJ 44,15,2005
oral
rat
lethal dose (50 percent kill): 750 mg/kg N/R TXAPA9 42,417,1977
oral
rat
lethal dose (50 percent kill): 750 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
subcutaneous
mouse
lethal dose (50 percent kill): 1,300 mg/kg N/R DCTODJ 44,15,2005
subcutaneous
rat
lowest published toxic dose: 96 mg/kg Skin: After systemic exposure: Dermatitis, other DCTODJ 44,15,2005
skin
guinea pig
lowest published toxic dose: 100 L/kg/1 hour Skin: After topical application: Primary irritation DCTODJ 44,15,2005
skin
rat
lowest published toxic dose: 1 pph Skin: After topical application: Primary irritation DCTODJ 44,15,2005
skin
rabbit
lethal dose (50 percent kill): 1,110 mg/kg N/R TXAPA9 42,417,1977
skin
rabbit
lethal dose (50 percent kill): 1,100 mg/m3 N/R DCTODJ 44,15,2005
skin
rabbit
lowest published toxic dose: 85 pph/15 minute Skin: After topical application: Primary irritation DCTODJ 44,15,2005
skin
rabbit
lowest published toxic dose: 6 pph Skin: After topical application: Primary irritation DCTODJ 44,15,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 50 ppm/3 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea
DCTODJ 44,15,2005
inhalation
guinea pig
lowest published toxic concentration: 50 ppm/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 44,15,2005
inhalation
mouse
lowest published toxic concentration: 800 mg/m3/16 day- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Dyspnea
DCTODJ 44,15,2005
inhalation
mouse
lowest published toxic concentration: 800 mg/m3/16 day- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
inhalation
mouse
lowest published toxic concentration: 800 mg/m3/16 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct DCTODJ 44,15,2005
inhalation
mouse
lowest published toxic concentration: 800 mg/m3/16 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes DCTODJ 44,15,2005
inhalation
mouse
lowest published toxic concentration: 267 mg/m3/16 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 5 gm/m3/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
inhalation
rat
lowest published toxic concentration: 215 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FAATDF 9,504,1987
inhalation
rat
lowest published toxic concentration: 360 g/m3/17 week- intermittent Cardiac: Other changes

Vascular: Other changes
GISAAA 23(11),71,1958
inhalation
rat
lowest published toxic concentration: 51 mg/m3/13 week- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 215 mg/m3/13 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 50 mg/m3/13 week- intermittent Olfaction: Other olfaction effects

Ear: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 1 mg/m3/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 800 mg/m3/16 day- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 800 mg/m3/16 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 267 mg/m3/16 day- intermittent Olfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects

Eye: Other eye effects
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 267 mg/m3/16 day- intermittent Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of exocrine pancreas

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 267 mg/m3/16 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 49 mg/m3/4 week- intermittent Eye: Ptosis

Behavioral: Somnolence (general depressed activity)
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 262 mg/m3/4 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 5,000 mg/m3/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 2,100 ppm/2 day- intermittent Olfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 2,100 ppm/2 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 2,100 ppm/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 1,050 ppm/11 day- intermittent Olfaction: Ulcerated nasal septum

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 1,050 ppm/11 day- intermittent Behavioral: Sleep

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
DCTODJ 44,15,2005
inhalation
rat
lowest published toxic concentration: 1,050 ppm/11 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 44,15,2005
oral
guinea pig
lowest published toxic dose: 400 mg/kg/20 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
DCTODJ 44,15,2005
oral
guinea pig
lowest published toxic dose: 400 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain DCTODJ 44,15,2005
oral
rat
lowest published toxic dose: 13,650 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain DCTODJ 44,15,2005
oral
rat
lowest published toxic dose: 4,200 mg/kg/2 week- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Irritability

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
oral
rat
lowest published toxic dose: 4,200 mg/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 44,15,2005
oral
rat
lowest published toxic dose: 3,000 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 44,15,2005
oral
rat
lowest published toxic dose: 2,700 mg/kg/6 day- intermittent Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 44,15,2005
oral
rat
lowest published toxic dose: 1,350 mg/kg/6 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain DCTODJ 44,15,2005
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain DCTODJ 44,15,2005
skin
rat
lowest published toxic dose: 1 pph/3 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin: After topical application: Primary irritation
DCTODJ 44,15,2005
skin
rabbit
lowest published toxic dose: 50 pph/12 day- intermittent Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 44,15,2005
skin
rabbit
lowest published toxic dose: 50 pph/12 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 44,15,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
DCTODJ ,15,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.3 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.3 mg/m3), OCT 2002
Occupational Exposure Limit - HUNGARY time-weighted average 2.3 mg/m3, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2.3 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83335;
Number of Industries 4;
Total Number of Facilities 62;
Number of Occupations 9;
Total Number of Employees Exposed 1,093
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83335;
Number of Industries 9;
Total Number of Facilities 879;
Number of Occupations 24;
Total Number of Employees Exposed 31,036;
Total Number of Female Employees Exposed 4,686


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as textile intermediate, wet strength resins, boiler feed water additives and adhesives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as textile intermediate, wet strength resins, boiler feed water additives and adhesives

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Reproductive Effector

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