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Hexamethylenetetramine

RTECS #: MN4725000

CAS #: 100-97-0


UPDATE: May 2008 MW: 140.22 MF: C6H12N4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3,5,7 - Tetraazaadamantane
  2. 1,3,5,7 - Tetraazatricyclo (3.3.1.1 (sup 37) ) decane
  3. Aceto HMT
  4. Aminoform
  5. Ammoform
  6. Ammonioformaldehyde
  7. Cystamin
  8. Cystogen
  9. Esametilentetramina (Italian)
  10. Formamine
  11. Formin
  12. HMT
  13. Hexaform
  1. Hexamethylenetetraamine
  2. Hexamethylenamine
  3. Hexamethyleneamine
  4. Hexamethylentetramin (German)
  5. Hexamethylentetramine
  6. Hexilmethylenamine
  7. Methamin
  8. Methenamine
  9. Preparation AF
  10. Resotropin
  11. Uritone
  12. Urotropin
  13. Urotropine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human HeLa cell 1 mmol/L HUMAA7 4,112,1967
dominant lethal test intraperitoneal
mouse
25 gm/kg DMWOAX 92,2315,1967
dominant lethal test oral
mouse
25 gm/kg HUMAA7 4,112,1967
DNA repair Bacillus subtilis 1 mg/disc SAIGBL 26,147,1984
DNA repair Escherichia coli 6 mg/well/16 hour CBINA8 15,219,1976
mutation in microorganisms Salmonella typhimurium 10 mg/plate (+/-enzymatic activation step) SAIGBL 27,400,1985
mutation in microorganisms Saccharomyes cerevisiae 150 mg/L/16 hour MUTAEX 20,105,2004
morphological transform hamster kidney 10 mg/L CRNGDP 4,457,1983
other mutation test systems human HeLa cell 100 Ámol/L HUMAA7 4,112,1967


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rat
lowest published toxic dose: 140 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
FAONAU 50A,71,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
mouse
lethal dose (50 percent kill): 17,700 ÁL/kg N/R ANTBAL 20,891,1975
intravenous
rat
lethal dose (50 percent kill): 9,200 mg/kg N/R AEPPAE 221,166,1954
oral
mouse
lethal dose (50 percent kill): 569 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GISAAA 35(3),115,1970
parenteral
cat
lowest published lethal dose: 200 mg/kg N/R IPSTB3 3,93,1976
parenteral
mammal (species unspecified)
lowest published lethal dose: 300 mg/kg N/R IPSTB3 3,93,1976
parenteral
mouse
lowest published lethal dose: 450 mg/kg N/R IPSTB3 3,93,1976
parenteral
rat
lowest published lethal dose: 200 mg/kg N/R IPSTB3 3,93,1976
subcutaneous
cat
lowest published lethal dose: 200 mg/kg N/R HBTXAC 1,84,1955
subcutaneous
guinea pig
lowest published lethal dose: 300 mg/kg N/R HBTXAC 1,84,1955
subcutaneous
mouse
lethal dose (50 percent kill): 215 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
AEPPAE 225,428,1955
subcutaneous
rat
lowest published lethal dose: 200 mg/kg N/R HBTXAC 1,84,1955


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 350 mg/m3/2 hour/3 week- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 35(3),115,1970
inhalation
rat
lowest published toxic concentration: 350 mg/m3/2 hour/3 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,227,1994
oral
rabbit
lowest published toxic dose: 525 mg/kg/15 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,227,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
AEMED3 45,609,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 4 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, Sen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 33675;
Number of Industries 49;
Total Number of Facilities 3,087;
Number of Occupations 59;
Total Number of Employees Exposed 30,437
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 33675;
Number of Industries 81;
Total Number of Facilities 9,101;
Number of Occupations 86;
Total Number of Employees Exposed 188,300;
Total Number of Female Employees Exposed 40,283


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a methylenating agent, as an intermediate, and an accelerator
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH.
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.) V.1-104, 1875-1979.
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ.
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a methylenating agent, as an intermediate, and an accelerator

NIOSH PROFILE (AMINES, TERTIARY AROMATIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), SRI, 2/77

NIOSH PROFILE (RUBBER MANUFACTURING, SYNTHETIC), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

ALT CAS #: 74734-16-0
Click Here for Additional Information about RTECS

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