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Registry of Toxic Effects of Chemical Substances (RTECS)

Hexamethylenetetramine

RTECS #

MN4725000

CAS #

100-97-0; 74734-16-0

Updated

July 2013

Molecular Weight

140.22

Molecular Formula

C6H12N4

Synonyms

1,3,5,7-Tetraazaadamantane
1,3,5,7-Tetraazatricyclo(3.3.1.1(sup 37))decane
Aceto HMT
Aminoform
Ammoform
Ammonioformaldehyde
Cystamin
Cystogen
Esametilentetramina (Italian)
Formamine
Formin
Hexaform
Hexamethylenamine
Hexamethyleneamine
Hexamethylenetetraamine
Hexamethylentetramin (German)
Hexamethylentetramine
Hexilmethylenamine
HMT
Methamin
Methenamine
Preparation AF
Resotropin
Uritone
Urotropin
Urotropine

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic AnalysisHeLa cell/human1 mmol/LHUMAA7 4,112,1967
DNA repair/Escherichia coli6 mg/well/16HCBINA8 15,219,1976
DNA repair/Bacillus subtilis1 mg/discSAIGBL 26,147,1984
Dominant Lethal Testintraperitoneal/mouse25 gm/kgDMWOAX 92,2315,1967
Dominant Lethal Testoral/mouse25 gm/kgHUMAA7 4,112,1967
morphological transformkidney/hamster10 mg/LCRNGDP 4,457,1983
mutation in microorganisms/Saccharomyes cerevisiae150 mg/L/16HMUTAEX 20,105,2004
mutation in microorganisms/Salmonella typhimurium10 mg/plate (+/-enzymatic activation step)SAIGBL 27,400,1985
other mutation test systemsHeLa cell/human100 µmol/LHUMAA7 4,112,1967

Tumorigenic Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat lowest published toxic dose: 140 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
FAONAU 50A,71,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 236.7 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.FCTOD7 50,2084,2012
intravenous/mouse lethal dose (50 percent kill): 17700 µL/kgANTBAL 20,891,1975
intravenous/rat lethal dose (50 percent kill): 9200 mg/kgAEPPAE 221,166,1954
oral/mouse lethal dose (50 percent kill): 569 mg/kgBehavioral: Excitement

Behavioral: Muscle contraction or spasticity
GISAAA 35(3),115,1970
parenteral/cat lowest published lethal dose: 200 mg/kgIPSTB3 3,93,1976
parenteral/mammal (species unspecified) lowest published lethal dose: 300 mg/kgIPSTB3 3,93,1976
parenteral/mouse lowest published lethal dose: 450 mg/kgIPSTB3 3,93,1976
parenteral/rat lowest published lethal dose: 200 mg/kgIPSTB3 3,93,1976
subcutaneous/cat lowest published lethal dose: 200 mg/kgHBTXAC 1,84,1955
subcutaneous/guinea pig lowest published lethal dose: 300 mg/kgHBTXAC 1,84,1955
subcutaneous/mouse lethal dose (50 percent kill): 215 mg/kgBehavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
AEPPAE 225,428,1955
subcutaneous/rat lowest published lethal dose: 200 mg/kgHBTXAC 1,84,1955

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 350 mg/m3/2H/3W- intermittentKidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 35(3),115,1970
inhalation/rat lowest published toxic concentration: 350 mg/m3/2H/3W- intermittentLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,227,1994
oral/rabbit lowest published toxic dose: 525 mg/kg/15W- intermittentLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVGK* -,227,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCMTVAS 10(3),49,1973
TOXICOLOGY REVIEWAEMED3 45,609,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, sen, NOV2011
Occupational Exposure Limit-NORWAYtime-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit-POLANDMAC(time-weighted average) 4 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 3 mg/m3;short term exposure limit 5 mg/m3, Sen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 33675; Number of Industries 81; Total Number of Facilities 9101; Number of Occupations 86; Total Number of Employees Exposed 188300; Total Number of Female Employees Exposed 40283
National Occupational Hazard Survey 1974Hazard Code 33675; Number of Industries 49; Total Number of Facilities 3087; Number of Occupations 59; Total Number of Employees Exposed 30437

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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