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Registry of Toxic Effects of Chemical Substances (RTECS)

Heptyl alcohol

RTECS #

MK0350000

CAS #

111-70-6

Updated

July 2011

Molecular Weight

116.23

Molecular Formula

C7H16O

Synonyms

1-Heptanol
1-Hydroxyheptane
Enanthic alcohol
l'Alcool N-heptylique primaire (French)
n-Heptanol
N-Heptanol-1 (French)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunctionlung/hamster2 mmol/LMUREAV 182,135,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: >16.5 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration Low: >16.1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 2.7 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: >8.2 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Mouse, macrophage Inhibitor Concentration Low: >16.5 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 6600 mg/m3GISAAA 51(5),61,1986
inhalation/mouse lethal concentration (50 percent kill): 6600 mg/m3Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
inhalation/mouse lethal concentration (50 percent kill): 6600 mg/m3/2H85GMAT -,72,1982
inhalation/mouse lowest published toxic concentration: 8.5 gm/m3/2HTPKVAL 5,51,1963
intraperitoneal/rat lowest published toxic dose: 256 mg/kgBehavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 5,51,1963
oral/mouse lethal dose (50 percent kill): 6000 mg/kgBehavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
oral/mouse lowest published lethal dose: 3.95 gm/kgBrain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral/mouse lethal dose (50 percent kill): 1500 mg/kgGISAAA 31,16,1966
oral/rabbit lethal dose (50 percent kill): 750 mg/kgHYSAAV 31(1-3),310,1966
oral/rat lethal dose (50 percent kill): 500 mg/kgLung, Thorax, or Respiration: Acute pulmonary edemaAMPMAR 35,501,1974
oral/rat lethal dose (50 percent kill): 3800 mg/kgBehavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
skin/rabbit lethal dose (50 percent kill): 2 gm/kgLung, Thorax, or Respiration: Acute pulmonary edemaAMPMAR 35,501,1974
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 4350 mg/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 180 mg/m3/2H/137D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,113,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 32 mg/m3/26W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Eye: Optic nerve neuropathy

Eye: Other eye effects
VCVGK* -,113,1994
inhalation/rat lowest published toxic concentration: 350 mg/m3/19W- intermittentBrain and Coverings: Other degenerative changes

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
NTIS** PB234-882
inhalation/rat lowest published toxic concentration: 0.27 gm/m3/107D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 5,51,1963
inhalation/rat lowest published toxic concentration: 0.27 gm/m3/137D- intermittentBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,51,1963
oral/rabbit lowest published toxic dose: 9100 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseGISAAA 31(3),16,1966
oral/rabbit lowest published toxic dose: 4.56 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,113,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTPHSDY 23,374,2002
TOXICOLOGY REVIEWMUREAV 628,67,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83568; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 17
National Occupational Hazard Survey 1974Hazard Code 83568; Number of Industries 2; Total Number of Facilities 44; Number of Occupations 6; Total Number of Employees Exposed 1105

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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