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Heptyl alcohol

RTECS #: MK0350000

CAS #: 111-70-6


UPDATE: February 2008 MW: 116.23 MF: C7H16O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Heptanol
  2. 1 - Hydroxyheptane
  3. Enanthic alcohol
  1. N - Heptanol - 1 (French)
  2. l'Alcool N - heptylique primaire (French)
  3. n - Heptanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sex chromosome loss and nondisjunction hamster lung 2 mmol/L MUREAV 182,135,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 6,600 mg/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse
lethal concentration (50 percent kill): 6,600 mg/m3/2 hour N/R 85GMAT -,72,1982
inhalation
mouse
lethal concentration (50 percent kill): 6,600 mg/m3 Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
inhalation
mouse
lowest published toxic concentration: 8.5 gm/m3/2 hour N/R TPKVAL 5,51,1963
intraperitoneal
rat
lowest published toxic dose: 256 mg/kg Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 5,51,1963
oral
mouse
lethal dose (50 percent kill): 1,500 mg/kg N/R GISAAA 31,16,1966
oral
mouse
lethal dose (50 percent kill): 6,000 mg/kg Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
oral
mouse
lowest published lethal dose: 3.95 gm/kg Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral
rat
lethal dose (50 percent kill): 500 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema AMPMAR 35,501,1974
oral
rat
lethal dose (50 percent kill): 3,800 mg/kg Behavioral: Ataxia

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
VCVGK* -,113,1984
oral
rabbit
lethal dose (50 percent kill): 750 mg/kg N/R HYSAAV 31(1-3),310,1966
skin
mouse
lowest published toxic dose: 100 pph/3 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive
TPKVAL 5,51,1963
skin
rabbit
lethal dose (50 percent kill): 2 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema AMPMAR 35,501,1974
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,51,1963
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 4,350 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 180 mg/m3/2 hour/137 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,113,1994
inhalation
mammal (species unspecified)
lowest published toxic concentration: 32 mg/m3/26 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Eye: Optic nerve neuropathy

Eye: Other eye effects
VCVGK* -,113,1994
inhalation
rat
lowest published toxic concentration: 350 mg/m3/19 week- intermittent Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes
NTIS** PB234-882
inhalation
rat
lowest published toxic concentration: 0.27 gm/m3/107 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 5,51,1963
inhalation
rat
lowest published toxic concentration: 0.27 gm/m3/137 day- intermittent Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,51,1963
oral
rabbit
lowest published toxic dose: 9,100 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase GISAAA 31(3),16,1966
oral
rabbit
lowest published toxic dose: 4.56 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,113,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TPHSDY 23,374,2002
TOXICOLOGY REVIEW
MUREAV 628,67,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83568;
Number of Industries 2;
Total Number of Facilities 44;
Number of Occupations 6;
Total Number of Employees Exposed 1,105
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83568;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 17


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Mutagen

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