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Registry of Toxic Effects of Chemical Substances (RTECS)

Heptanoic acid

RTECS #

MJ1575000

CAS #

111-14-8

Updated

July 2011

Molecular Weight

130.21

Molecular Formula

C7H14O2

Synonyms

1-Hexanecarboxylic acid
Enanthic acid
Enanthylic acid
Heptylic acid
Hexacid C-7
n-Heptoic acid
n-Heptylic acid
Oenanthic acid
Oenanthylic acid

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6600 mg/kg (7D pre-4D after birth)Reproductive: Other effects on femaleHPV160 -,-,2001
oral/rat 66000 mg/kg (7D pre-4D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
HPV160 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): >1000 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 17,717,2003
inhalation/rat lethal concentration (50 percent kill): >4600 mg/m3/4HHPV160 -,-,2001
intravenous/mouse lethal dose (50 percent kill): 1200 mg/kgHPV160 -,-,2001
intravenous/mouse lethal dose (50 percent kill): 1200 mg/kgBehavioral: Convulsions or effect on seizure thresholdAPTOA6 18,141,1961
oral/mouse lethal dose (50 percent kill): 6400 mg/kgBIJOAK 34,1196,1940
oral/rat lethal dose (50 percent kill): 7 gm/kgFDRLI* 123,-,1976
oral/rat lethal dose (50 percent kill): 8370 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
HPV160 -,-,2001
skin/rabbit lethal dose (50 percent kill): >2000 mg/kgHPV160 -,-,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 94500 mg/kg/27D- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Gastritis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV160 -,-,2001
skin/rabbit lowest published toxic dose: 5000 mg/kg/2W- intermittentBehavioral: Food intake (animal)

Skin: After topical application: Primary irritation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV160 -,-,2001

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAMIHAB 21,100,1960

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84195; Number of Industries 33; Total Number of Facilities 1751; Number of Occupations 32; Total Number of Employees Exposed 34035; Total Number of Female Employees Exposed 2138
National Occupational Hazard Survey 1974Hazard Code 84195; Number of Industries 2; Total Number of Facilities 31; Number of Occupations 3; Total Number of Employees Exposed 981

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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