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Registry of Toxic Effects of Chemical Substances (RTECS)

Guanidine, 1,3-diphenyl-

RTECS #

MF0875000

CAS #

102-06-7

Updated

April 2012

Molecular Weight

211.29

Molecular Formula

C13H13N3

Synonyms

1,3-Difenylguanid (Czech)
1,3-Diphenylguanidine
Accelerator D
Denax
Denax DPG
Diphenylguanidine
DPG accelerator
Dwufenyloguanidyna (Polish)
Melaniline
N,N'-Diphenylguanidine
NCI-C60924
Nocceler D
sym-Diphenylguanidine
USAF B-19
USAF EK-1270
Vulcafor DPG
Vulkacit D
Vulkacit D/C
Vulkazit

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 1%/48HCODEDG 11,256,1984

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/mouse36 ng/kgJEPOEC 6(1-2),293,1985
mutation in microorganisms/Salmonella typhimurium360 ng/plate (+enzymatic activation step)JEPOEC 6(1-2),293,1985
mutation in microorganisms/Salmonella typhimurium33 µg/plate (-enzymatic activation step)ENMUDM 8(Suppl 7),1,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 76 mg/kg (1-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJEPTDQ 4(1),451,1980
oral/mouse 190 mg/kg (1-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)JEPTDQ 4(1),451,1980
oral/mouse 56 mg/kg (7D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
JTEHD6 11,869,1983
oral/mouse 196 mg/kg (49D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)JTEHD6 11,869,1983
oral/mouse 140 mg/kg (35D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJTEHD6 11,869,1983
oral/hamster 224 mg/kg (56D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)JTEHD6 11,869,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 100000 mg/m3HPV011 -,-,2003
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgHPV011 -,-,2003
intraperitoneal/rat lethal dose (50 percent kill): 75 mg/kgMEPAAX 16,35,1965
intravenous/Dog lowest published lethal dose: 25 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tetany
CRSBAW 143,815,1949
intravenous/Dog lowest published lethal dose: 25 mg/kgHPV011 -,-,2003
oral/Dog lowest published toxic dose: 10 mg/kgGastrointestinal: Nausea or vomitingHPV011 -,-,2003
oral/guinea pig lethal dose (50 percent kill): 250 mg/kgHPV011 -,-,2003
oral/mammal (species unspecified) lowest published lethal dose: 250 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
JIDHAN 13,87,1931
oral/mouse lethal dose (50 percent kill): 290 mg/kgHPV011 -,-,2003
oral/mouse lethal dose (50 percent kill): 150 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia
SRTCAC 36(1-4),10,1989
oral/rabbit lethal dose (50 percent kill): 250 mg/kgHPV011 -,-,2003
oral/rat lethal dose (50 percent kill): 350 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Other changes

Blood: Hemorrhage
HPV011 -,-,2003
oral/rat lethal dose (50 percent kill): 323 mg/kgNTPTR* NIH-95-3933
skin/rabbit lethal dose (50 percent kill): >794 mg/kgNTPTR* NIH-95-3933
skin/rabbit Lethal dose: >2000 mg/kgHPV011 -,-,2003
subcutaneous/guinea pig lowest published lethal dose: 200 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tetany
CRSBAW 143,815,1949
subcutaneous/guinea pig lowest published lethal dose: 200 mg/kgHPV011 -,-,2003
subcutaneous/rabbit lowest published toxic dose: 20 mg/kgBehavioral: Convulsions or effect on seizure thresholdHPV011 -,-,2003
subcutaneous/rabbit lowest published toxic dose: 50 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HPV011 -,-,2003
unreported route/mouse lethal dose (50 percent kill): 258 mg/kgBlood: Normocytic anemiaGISAAA 43(7),35,1978
unreported route/rabbit lethal dose (50 percent kill): 246 mg/kgBlood: Normocytic anemiaGISAAA 43(7),35,1978
unreported route/rat lethal dose (50 percent kill): 323 mg/kgBlood: Normocytic anemiaGISAAA 43(7),35,1978

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 1288 mg/kg/2W- intermittentCardiac: Changes in heart weight

Endocrine: Differential effect of sex or castration on observed toxicity
HPV011 -,-,2003
oral/mouse lowest published toxic dose: 3724 mg/kg/2W- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight

Endocrine: Differential effect of sex or castration on observed toxicity
HPV011 -,-,2003
oral/rabbit lowest published toxic dose: 8250 mg/kg/165D- intermittentLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
HPV011 -,-,2003
oral/rat lowest published toxic dose: 6825 mg/kg/13W- intermittentReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)HPV011 -,-,2003
oral/rat lowest published toxic dose: 504 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV011 -,-,2003
oral/rat lowest published toxic dose: 784 mg/kg/14D- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight

Endocrine: Changes in spleen weight
HPV011 -,-,2003
oral/rat lowest published toxic dose: 784 mg/kg/14D- intermittentCardiac: Changes in heart weight

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV011 -,-,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 27760; Number of Industries 14; Total Number of Facilities 874; Number of Occupations 40; Total Number of Employees Exposed 28146; Total Number of Female Employees Exposed 4339
National Occupational Hazard Survey 1974Hazard Code 27760; Number of Industries 10; Total Number of Facilities 326; Number of Occupations 21; Total Number of Employees Exposed 14344

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9186;8EHQ-0892-9256
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Toxicity studies, RPT# TOX-42, October 2000
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